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Vinko Palada

@drvinkopalada.bsky.social

Neuroscientist ๐Ÿง  PI and Docent @helsinki.fi Pain Chronotherapies | Effects of analgesics on sleep and circadian rhythms I Neuropathic pain and associated comorbidities ๐ŸŒ…โฐ๐Ÿ’Š https://www.linkedin.com/in/vinkopalada

101 Followers  |  334 Following  |  3 Posts  |  Joined: 24.07.2025  |  1.5577

Latest posts by drvinkopalada.bsky.social on Bluesky

Identified rhythmic transcripts with altered rhythmicity may play important roles in circadian regulation of neuropathic pain and potentially might be targets for chronotherapies to relieve pain.

24.07.2025 17:13 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Our study shows that nerve injury in mice disrupts the rhythmic expression of hundreds of transcripts in spinal cord and periaqueductal gray, two key regions in pain modulation that are both under strong circadian control. Immune-related genes were predominantly affected by circadian disruption.

24.07.2025 17:11 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Circadian disruption upon painful peripheral nerve injury in mice: Temporal effects on transcriptome in pain-regulating sensory tissues Neuropathic pain (NP) resulting from nerve damage shows diurnal fluctuation of intensity in patients, indicating circadian regulation. However, mechanโ€ฆ

I am pleased to share our new paper that explores the effects of painful nerve injury on temporal changes in transcriptome in pain-regulating sensory tissues.

Read more here:
www.sciencedirect.com/science/arti...

24.07.2025 17:10 โ€” ๐Ÿ‘ 6    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

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