Differential Effects of Pregabalin and Morphine on the Sleep-Wake Cycle and Circadian Rhythms in Mice with Neuropathic Pain - PubMed
Pregabalin, unlike morphine, restores SNI-disrupted sleep architecture, circadian rhythms, and spinal circadian gene expression.
🎉 Excited to share that our latest research has been accepted for publication in Anesthesiology!
Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.
pubmed.ncbi.nlm.nih.gov/40802988/
26.08.2025 08:39 — 👍 3 🔁 2 💬 0 📌 1
Identified rhythmic transcripts with altered rhythmicity may play important roles in circadian regulation of neuropathic pain and potentially might be targets for chronotherapies to relieve pain.
24.07.2025 17:13 — 👍 0 🔁 0 💬 0 📌 0
Our study shows that nerve injury in mice disrupts the rhythmic expression of hundreds of transcripts in spinal cord and periaqueductal gray, two key regions in pain modulation that are both under strong circadian control. Immune-related genes were predominantly affected by circadian disruption.
24.07.2025 17:11 — 👍 0 🔁 0 💬 1 📌 0
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Pain scientist. Asst Clinical prof @ UCSF, lecture @ Stanford. Psychologist. Disruptor. Author📚 The Pain Management Workbook. Neuroscience nerd 🧠 #medsky #medtwitter #SciComm #neuroskyence
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PhD researcher at University of Helsinki & clinical biomechanist at Helsinki University Hospital #spinalcordinjury #cerebralpalsy #neuromodulation #rehabilitation #3Dmovementanalysis #gaitanalysis
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Kevin Keay and Lab of Neural Structure & Function || Neuroscience of emotional coping in chronic pain || Science and Life || 🧠🌏🏳️🌈
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Assoc Prof, UToronto Pain Scientist
Co-Director, Centre for Multimodal Sensorimotor and Pain Research;
Canada Research Chair in Pain NeuroImaging;
Councillor, IASP; Secretary, CanPainSoc
fMRI, EEG, Psychophysics.
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University College Cork
Stress| Hippocampal neurogenesis| Gut feelings and the hippocampus| Microbiome-gut-brain axis| Sex differences| Female hormonal transition periods across the lifespan
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