Vinko Palada

Differential Effects of Pregabalin and Morphine on the Sleep-Wake Cycle and Circadian Rhythms in Mice with Neuropathic Pain - PubMed Pregabalin, unlike morphine, restores SNI-disrupted sleep architecture, circadian rhythms, and spinal circadian gene expression.

🎉 Excited to share that our latest research has been accepted for publication in Anesthesiology!

Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.

pubmed.ncbi.nlm.nih.gov/40802988/

Identified rhythmic transcripts with altered rhythmicity may play important roles in circadian regulation of neuropathic pain and potentially might be targets for chronotherapies to relieve pain.

Our study shows that nerve injury in mice disrupts the rhythmic expression of hundreds of transcripts in spinal cord and periaqueductal gray, two key regions in pain modulation that are both under strong circadian control. Immune-related genes were predominantly affected by circadian disruption.

Circadian disruption upon painful peripheral nerve injury in mice: Temporal effects on transcriptome in pain-regulating sensory tissues Neuropathic pain (NP) resulting from nerve damage shows diurnal fluctuation of intensity in patients, indicating circadian regulation. However, mechan…

I am pleased to share our new paper that explores the effects of painful nerve injury on temporal changes in transcriptome in pain-regulating sensory tissues.

Read more here:
www.sciencedirect.com/science/arti...