Chloe Lopez-Lee

I am thrilled to announce that I will be starting my lab at
@washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses mic...

"A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against #AlzheimersDisease by suppressing inflammatory signaling in the brain’s immune cells."

Learn More in Immunity @cellpress.bsky.social
www.cell.com/immunity/abs...

My postdoc work from the Gan Lab is out now! 👇
The incredible @sarahnaguib.bsky.social and @chloelopezlee.bsky.social drove this project to completion and I'm so proud of the work put in and grateful to all the contributions from Gan lab members and collaborators. 🧠

Grateful for the opportunity to co-lead this study with @liganlab.bsky.social, @sarahnaguib.bsky.social, and @ertorres.bsky.social! We peel back layers of the protective Christchurch mutation to identify underlying mechanisms and transfer protection to non-Christchurch models with neurotoxic tau 💫

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

And the full paper is here - www.pnas.org/doi/abs/10.1....

Thanks to Dave and Joseph for the nice coverage!