Alessandro Romanel

Huge kudos to @abio.bsky.social and Filippo Gastaldello, and our collaborators Gianluca Lattanzi and Davide Dalfovo.

HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences Abstract. Deciphering the functional effects of genetic variants, especially those inherited together on the same haplotype, remains a major challenge in h

🚨 Out in NAR @narjournal.bsky.social!

Introducing HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences.

📄 Paper: doi.org/10.1093/nar/...
💻 DB: bcglab.cibio.unitn.it/hapscoredb

#Bioinformatics #Genomics #ProteinLanguageModels #CompBio

Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer | EMBO reports imageimageLeveraging mouse adult prostate organoids reveals regulators of prostatic luminal lineage commitment. The androgen pathway together with retinoic acid/Rarγ/Foxa1 signaling programs luminal p...

Our latest collaborative project co-led by Dario De Felice, Alessandro Alaimo, @bresdavide.bsky.social, and Andrea Lunardi at CIBIO UniTrento 🔬 🧫 🧬

We generated pro-luminal prostate organoid models and found that common FOXA1 cancer indels are loss-of-function

www.embopress.org/doi/full/10....

SpikeFlow: automated and flexible analysis of ChIP-Seq data with spike-in control Abstract. ChIP with reference exogenous genome (ChIP-Rx) is widely used to study histone modification changes across different biological conditions. A key

Are you looking for a tool to analyze ChIP-seq data with spike-in control?

Check out SpikeFlow 👇

academic.oup.com/nargab/artic...