Lotte B. Pedersen

Nice work indeed… among all the interesting findings, quite amazed to see that you can induce the formation of ciliary pockets just by the removal of Arp3! #cilia #ciliopathies #kidney

Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....

JCS snapshots: the cilia and flagella edition - FocalPlane JCS snapshots: the cilia and flagella edition - News

We’re excited for the UK Cilia and Centrosome Network e-symposium this afternoon featuring the #JCSciliaSI!

To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...

BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

And we’ll be back for four sessions in 2026- first 14/01/2026! Register: www.eventbrite.co.uk/e/bscb-genso...
#UKCilia2025 /9

Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.

In the meantime, try a deep dive into our JCS Special Issue on Cilia and Flagella to fully immerse yourself into some great research, fantastic insight and provocative opinions: journals.biologists.com/jcs/issue/13... /fin

Thanks for the shoutout! @jcellsci.bsky.social :)

It was a lot of fun to write this review on cilia proteimics with Bernhard Schermer @cilib.social.cologne.ap.brid.gy and Ronald Ropeman, and we are excited to see it published in the @jcellsci.bsky.social special issue on Cilia and Flagella: from basic Biology to Disease.

Figure showing that tissue-resident macrophages promote cytogenesis in an in vitro 3D model system.

Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...

An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...

Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...

JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News

While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.

And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!

Akisato Marumo, Hiroto Ishii, Shin Yamaguchi, Junichiro Yajima and colleagues characterise the 3D beating pattern of the ciliary tip in the live ciliate Tetrahymena.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish

Imaging Cell Dynamics 11-14 May 2026 Montanyà Hotel, Catalonia, Spain Register now - early-bird deadline: 16 January 2026 Journal of Cell Science Meeting

Registration is now open to attend Journal of Cell Science's meeting on Imaging Cell Dynamics, organised by Francesca Bottanelli, Guillaume Jacquemet, Michael Way and Giulia Zanetti.

Find out more: biologists.com/meetings/jcs...

#JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience

Figure showing that EP4 localizes to primary cilia of ASCs.

Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
#JCSciliaSI
journals.biologists.com/jcs/article/...

News and Publications - TheRaCil

🥳TheRaCil Publications Alert🚨Visit theracil.eu/news-and-pub... - cilia biology & perspectives for AI in nephrology👉KIF13B controls ciliary protein content, Rezi et al @lottepedersen.bsky.social 👉AI for diagnosis and care in rare kidney disease review, Chen et al @knebel.bsky.social #cilia #kidney

Figure showing that both overexpression of and loss of PPK-1 impacts shedding of CLHM-1-containing EVs.

Malek Elsayyid, Alexis Semmel, Jessica Tanis and colleagues find that phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons.
#JCSciliaSI
journals.biologists.com/jcs/article/...

Keren Hilgendorf

Girish Ram Mali

Also in Issue 20:
- Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
- 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social
journals.biologists.com/jcs/issue/13...
#JCSciliaSI

Advances in high-resolution imaging of centrioles and cilia Summary: A review of the progressive advances in light and electron microscopy that have revealed unprecedented structural and molecular insights into centrioles and cilia, and reshaped our view of th...

Exciting news: the new review from @centriolelab.bsky.social is out in the amazing #JCSciliaSI! 🎉
I had the pleasure of working alongside Olivier Mercey, Paul Guichard and Virginie Hamel on this one.
Cherry on top: our #UExM image was selected for the cover of the issue! 🤩

Thanks for your contribution and the fabulous cover image!

We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...

This is our first submission to @jcellsci.bsky.social and the experience was fantastic. We will absolutely be submitting here in the future. Highly recommended.

We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.

It was a great pleasure working with @cilialab.bsky.social and @seemagrewal.bsky.social plus others at @jcellsci.bsky.social on this special issue on ‘Cilia and flagella’. Lots of cool stuff on #cilia #flagella in there, enjoy!

Advances in ciliary proteomics – towards cracking the hidden proteome code of cilia Summary: This Review explores proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labeling techniques.

📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏
Hope we didn’t miss anything important - apologies if we did!

#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social

tinyurl.com/yc8ztn5v

Thanks for your excellent contribution!

CiliaQ Editor just received a convenient upgrade allowing to faster inspect and correct segmentations of #cilia in the #CiliaQ workflow (automatic color & BC adjustment, new functions, etc.). If you update FIJI, you automatically update to the new version. All details at github.com/hansenjn/Cil....

Microtubule inner proteins – bridging structure and function in ciliary biology Summary: Microtubule inner proteins (MIPs) have been brought into focus by the cryo-EM revolution. This Review outlines current knowledge, emerging functions, links to ciliopathies and outstanding que...

Ever wondered what microtubule inner proteins (MIPs) are and what they actually do? Or perhaps you already know about them, but find it hard to keep track of which ones are conserved across species and how they support ciliary structure and function?
journals.biologists.com/jcs/article/...

a man stands in front of a white board with the words keep that in mind written on it ALT: a man stands in front of a white board with the words keep that in mind written on it

Miao Gui and I wrote a Review for the @jcellsci.bsky.social special issue “Cilia and Flagella: From Basic Biology to Disease”. It provides a comprehensive and up-to-date overview of MIP structure, function, and the latest tools used to study them, crafted to serve both newcomers and experts.

Thanks for your excellent contribution @orbachron.bsky.social!

This was a fun chat. Thanks @jcellsci.bsky.social for featuring me and spotlighting our work.

Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....

We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.

Primary cilia signalling at a glance Summary: We explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways to guide development and maintain homeostasis. Its dysfunction trigge...

I’m excited to share this collaborative work with Prof. Dagmar Wachten (@wachtenlab.bsky.social), providing an accessible overview of primary cilia signalling and recent advances in cellular signaling in health and disease. Many thanks to Dagmar for a fantastic collaboration! doi.org/10.1242/jcs....