Lotte B. Pedersen

Save the date!
March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳
Stay tuned for more info!

Congratulations Kat and team, looking forward to reading it! 🤩👏👏

Congratulations Girish and team 👏👏

The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture - Nature Communications The CPLANE complex is essential for ciliogenesis, and mutations to all but one subunit have been associated with ciliopathies. Here they identify three familial mutations in the final subunit, RSG1, t...

Cilia Alert! So excited to finally have this paper on the CPLANE complex out in @natcomms.nature.com! We show that RSG1 is a human ciliopathy protein and links CPLANE to the transition zone. 1/n

www.nature.com/articles/s41...

Pleasantine @cilialab.bsky.social‬ is coordinating our Special Issue – Cilia and Flagella: from Basic Biology to Disease together with Lotte Pedersen @lottepedersen.bsky.social‬. The issue is now open, and you can view our ToC here: journals.biologists.com/jcs/issue/13...
#JCSciliaSI

Very happy to find our last article in Kidney International Reports online today!
#cilia #ciliopathies #kidney

A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impair various signal-transduction pathways and cause ciliopathies. Although K63-linked ubiquitination appears to trigger protein export from cilia, the mechanisms coupling polyubiquitinated proteins to IFT remain unclear. Using a multidisciplinary approach, we demonstrate that a complex of CFAP36, a conserved ciliary protein of previously unknown function, and ARL3, a GTPase involved in ciliary import, binds polyubiquitinated proteins and links them to retrograde IFT trains. CFAP36 uses a coincidence detection mechanism to simultaneously bind two IFT subunits accessible only in retrograde trains. Depleting CFAP36 accumulates K63-linked ubiquitin in cilia and disrupts Hedgehog signaling, a pathway reliant on the retrieval of ubiquitinated receptors. These findings advance our understanding of ubiquitin-mediated protein transport and ciliary homeostasis, and demonstrate how structural changes in IFT trains achieve cargo selectivity. ### Competing Interest Statement The authors have declared no competing interest. Sara Elizabeth O'Brien Trust Postdoctoral Fellowship awarded through the Charles A. King Trust Postdoctoral Research Fellowship Program, , 8460873-01 Richard and Susan Smith Family Foundation, https://ror.org/05j95n956, National Institute of General Medical Sciences (NIGMS), , R01GM141109, R01GM143183

How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n

Just out! We used C. elegans to trace the cargo of ciliary EVs and found that their loading is a regulated process involving polycystins. @barrlab.bsky.social communities.springernature.com/posts/tiny-m...

Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans - Nature Communications Decoding the content of extracellular vesicles (EVs) is key to understanding cell communication. Nikonorova et al. used targeted proximity labeling to uncover polycystin EV cargo and cargo-loading mec...

Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans
www.nature.com/articles/s41...

Special Issue Cilia and Flagella: from Basic Biology to Disease Guest Editors: Pleasantine Mill and Lotte Pedersen Extended submission deadline: 1 March 2025 Journal of Cell Science logo Call for papers

Today is the last day to submit to @jcellsci.bsky.social's upcoming special issue on cilia and flagella. This issue will be coordinated by two Guest Editors: Pleasantine Mill
@cilialab.bsky.social
and Lotte Pedersen
@lottepedersen.bsky.social

journals.biologists.com/jcs/pages/ci...

Looking for a home for your #cilia submission? Still time to be part of this special issue of the Journal of Cell Science- the journal for the cell biology community, by the cell biology community! ⏰ Reach out to @lottepedersen.bsky.social or I to discuss....

Micheal Way Editor of Journal of Cell Science launching the ECR award for best paper named for the late and much missed David Stephens.

Great pitch for why to submit, review & write for @jcellsci.bsky.social by @drmichaelway.bsky.social - for the cell biology community, by the cell biology community💪! And great to see on screen the ECR best paper award launched in the late and much missed David Stephens’ name! #WeNeedMoreDavids

Journal of Cell Science logo Meet the Editor at Biologists @ 100: Lotte B. Pedersen Areas of expertise: Cell biology, primary cilia, centrosomes, intraciliary trafficking (IFT), cilia assembly, signalling via cilia.

Our Guest Editor @lottepedersen.bsky.social is attending our Biologists @ 100 conference. Reach out to Lotte if you have questions about submitting your research to our special issue on cilia and flagella biology: journals.biologists.com/jcs/pages/ci...
Submission deadline: 31 March
#biologists100

Do you qualify for APC-free Open Access publishing? Find out at biologists.com/read-publish/institutions

Attending Biologists @ 100? Visit our booth in Hall 2 to find out if your institution is participating in our Read & Publish initiative and you qualify for fee-free #OpenAccess publishing with us. www.biologists.com/library-hub/...
#biologists100

Flagellum structures of Trypanosoma parasite reveal how molecular motors drive the movement. Incredible back to back papers in Science by @alanbrownhms.bsky.social & @ruizhangmt.bsky.social, Hong Zhou & Kent Hill.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

3) Result of great team-work by Csenge K. Rezi, Alina Frei, Fabiola Campestre, Helen May-Simera, Karsten Boldt, @sorentc.bsky.social and others

2) Here is the model we propose:

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia Dynamic control of ciliary membrane protein content is crucial for organelle homeostasis and signaling function and involves removal of ciliary components by BBSome-mediated export, endocytic retrieva...

1) We have updated our preprint on #cilia and #extracellular vesicles, which is regulated by #KIF13B: www.biorxiv.org/content/10.1...

Special Issue Cilia and Flagella: from Basic Biology to Disease Guest Editors: Plesantine Mill and Lotte Pedersen Submission deadline: 1 March 2025 Journal of Cell Science logo Call for papers

Only a few days left to submit your latest research to @jcellsci.bsky.social‬ 's upcoming Special Issue on #cilia and #flagella, coordinated by Pleasantine Mill @cilialab.bsky.social & Lotte Pedersen @lottepedersen.bsky.social .
📆 Deadline: 1 March
https://bit.ly/4ed1Re7

#CallforPapers #CellBio

Come join us in Copenhagen! There is still time to apply for the 2 vacant PhD positions available in our group -for more info see below #cilia

🚨 Fantastic opportunity to conduct a PhD in Europe! European funding and fantastic international community! 👩‍🎓

A primary cilia–autophagy axis in hippocampal neurons is essential to maintain cognitive resilience - Nature Aging Exploring the molecular mechanisms by which the blood-borne factor osteocalcin promotes cognitive resilience, Rivagorda, Romeo-Guitart et al. identify a primary cilia axis through which osteocalcin pr...

Nice work by my former colleague Franck Oury, on a new function for osteocalcin in the primary cilia!

www.nature.com/articles/s43...

“Join the Pigino Lab! We’re hiring a PhD student to explore primary cilia biology using advanced imaging, spatial ‘omics, and AI. Apply now at www.cilia-ai.eu and be part of the Cilia-AI Doctoral Network!”

Ex-NFL punter Chris Kluwe calls MAGA 'a Nazi movement' in protest that led to his arrest Chris Kluwe was arrested Tuesday on a charge of disturbing an assembly. He staged an anti-MAGA protest during a Huntington Beach city council meeting.

"MAGA is explicitly a Nazi movement. You may have replaced a swastika with a red hat, but that is what it is." www.usatoday.com/story/sports...

Congrats Max and team!👏👏

New paper! journals.plos.org/plosbiology/...
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.

#medlib
EuropePMC cannot be taken down by any US organisation. Maybe share this resource with colleagues, especially those in USA.

Your Action Is Needed!

Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy

www.ascb.org/science-poli...

🧪The Genetics Society of America "our commitment to inclusivity is unwavering and we will continue to advocate for scientific research and the advancement of the field." @genetics-gsa.bsky.social

genestogenomes.org/letter-from-...

What can we do?

Scientists are on our own. University leaders at big schools are not going to help us.

Do what you can to connect with your colleagues. Plan local actions. If you can speak out to the media about what's happening to science, you're critical right now, please do speak out.

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