Simon Bayly

Albini Sessions (Benefit for Letters Charity), by Fugazi 12 track album

Stop literally everything.

Steve Albini's Fugazi sessions, widely bootlegged and full of lore, now available officially for the first time.

fugazi.bandcamp.com/album/albini...

Bluesky map, now with posts read aloud 🔈 - pretty trippy

bluesky-map.theo.io?live=1&reada...

Chrome recommended. Uses significant bandwidth to download TTS voices.

I'm not smearing faeces on the walls, I'm daubing excrement on the masonry

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation Proteolysis-targeting chimeras (PROTACs) have transformed the concept of chemical intervention in biological systems by co-opting the ubiquitin–proteasome system to selectively degrade proteins. A key...

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation

Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs @science.org @columbiauniversity.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Any relation to Paul Seixas?

Grand Challenges for Predictive Modeling in Small Molecule Drug Discovery
chemrxiv.org/doi/full/10....
#chemsky

It turns out that I am situated in the uncharted backwaters of the unfashionable end of the Western spiral arm of the Bluesky galaxy

It turns out that I am situated in the uncharted backwaters of the unfashionable end of the Western spiral arm of the Bluesky galaxy

'Jumbo cyanophage' 🐘🦠

Interesting that longstanding tech investor Seedcamp is making its first forays into bio

I fucking hate proline so fucking much it's the worst amino acid it's so fucking stupid it's incapable of being fucking normal so it forms an ugly ass ring with itself with its own fucking nitrogen cuz it's a loser fucking amino acid I hate it so much I'd rather cut off my right tit than have to ever draw a mechanism with proline ever again

Remember that everyone you meet is fighting their own battle, sometimes with amino acids

See also the Conservatives. And current Labour policies are bad even if workable.

Glasgow Uni spin-out raises £1.6M for cancer-detecting AI - United Kingdom A spin-out company from the University of Glasgow has secured £1.6M seed investment to launch AI technology that is learning ‘the language of cancer’ to

Glasgow Uni spin-out raises £1.6M for cancer-detecting AI

https://www.europesays.com/uk/798893/

A spin-out company from the University of Glasgow has secured £1.6M seed investment to launch AI technology that…#uk #news #uknews

Anybody doing proteomics on FACS sorted cells? People are using BSA coated tubes to avoid cell adhesion onto the walls. BSA is all over the protein extract. How to avoid this BSA? Saw Polyvinyl alcohol (PVA) can be used in place of BSA. Any experience with its compatibility for downstream MS? Thanks

Call me a luddite, anti-technology, or whatever, but I still have yet to see a use of AI in the pharmaceutical industry that actually improved the science at the bench level.

#Ichoseviolence
Yes, I am trolling to start my next cull...

Why an industry career move is a taboo topic in academia Adam Levy investigates why researchers are sometimes reluctant to disclose their plans to colleagues.

Is this a genuine headline in the year 2026, or is it clickbait?
www.nature.com/articles/d41...

Criminal and shameful

An interesting way to think of embryo development is like evolution - starting as a tube/worm, becoming fish-like then amphibian-like before losing its tail and turning mammalian

The stage after blastocyst is called gastrulation

Putting the "LLM" in "Gell-Mann amnesia"

Investors have already responded to Trump 2 by putting more of their money into other parts of the world. The Anthropic case is exactly what they feared. The rule of law does not exist in the US today. No investment is safe under fascism. Hence the avoidance of the US is going to intensify.

Atrium spins out of Avidity, aiming to target rare heart diseases with RNA - Switzerland A newly formed spinout of recently acquired Avidity Biosciences debuted Friday with plans to pick up some of its predecessor’s work. 

Atrium spins out of Avidity, aiming to target rare heart diseases with RNA

https://www.europesays.com/ch/21168/

A newly formed spinout of recently acquired Avidity Biosciences debuted Friday with plans to pick up some of…

Behind Generate's 'feverish' race to raise $400M IPO while window remains open Generate:Biomedicines is the latest biotech to benefit from a renewed appetite from investors for publicly listed drug developers. | Generate:Biomedicines is the latest biotech to benefit from a renew...

Has the winter ended for biotech IPOs? www.fiercebiotech.com/biotech/gene...

biotech CRO M&A shenangigans
biotechreporter.news/iqvia-to-acq...

Worm swarms 😱
www.pnas.org/doi/10.1073/...

Unarguable!

Aliister Heath: The establisment's embrace of gin and tonic is the greatest scandal of out age

quite mad

Integrase anchors viral RNA to the HIV-1 capsid interior - Nature HIV-1 integrase forms an RNA-binding module on the luminal side of the mature capsid lattice.

biology just loves making dual use technology www.nature.com/articles/s41...

Integrase anchors viral RNA to the HIV-1 capsid interior - Nature HIV-1 integrase forms an RNA-binding module on the luminal side of the mature capsid lattice.

biology just loves making dual use technology www.nature.com/articles/s41...