Lenny Teytelman

Optimisation of whole cell human depletion provides increased sensitivity and microbial genome coverage from respiratory metagenomic assays Metagenomics is being adopted worldwide as a laboratory developed test. We have previously reported a unified metagenomic method for the direct detection of microorganisms from respiratory samples, de...

Our new preprint covering the improvements we made to our respiratory metagenomic assay is out now:

www.medrxiv.org/content/10.1...

✅ Now implemented in 6 NHS hospitals
✅ Increased sensitivity
✅ Increased pathogen genome coverage

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BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

✨ Research assessment needs a rethink — and it finally feels like change might be possible.
At protocols.io (@protocolsio.bsky.social) and in my past life as a journal editor, I’ve had countless conversations about how we evaluate researchers. It’s a topic that keeps coming up — and for good reason.

Bring structure to your research - protocols.io A secure platform for developing and sharing reproducible methods.

Explore our new featured protocols protocols.io/welcome

Opinion | Can Trump End This Impossibly Cruel Practice?

In which I look at animal research for The New York Times and find some surprising answers.

Listening to #WhatTheRef podcast on the train en route to Birmingham for The Festival of Hidden Ref tomorrow and Weds, perfect listening material, thanks @hiddenref.bsky.social,
I'm giving a lightning talk on Thurs - very much looking forward to this event :)

Global Collaboration Made Easier: Multilingual Protocols Now Available on protocols.io Research is a global endeavour, yet the expectation to communicate in English often creates barriers and an additional burden for non-native speakers. At the lab bench or in t...

I've been dreaming about this for a decade and it's now live!

"Global Collaboration Made Easier: Multilingual Protocols Now Available on protocols.io"
www.protocols.io/blog/global-...

Copy our protocols!

📝 Find many of our lab protocols and techniques on @protocolsio.bsky.social at www.protocols.io/search?q=%22...

🎥 Go deeper with recorded video tutorials of some of our most requested methods: alleninstitute.org/education/sc...

#OpenScienceWeek

Plate CUT&Tag (Meers Lab version) This protocol describes a method for carrying out CUT&Tag-Direct in 96 well microplates for high-throughput processing of samples by a single operator with only standard lab...

We published a detailed protocol for our Plate-CUT&Tag method on @protocolsio.bsky.social to accompany our recent preprint (www.biorxiv.org/content/10.1...) give it a try! Feedback welcome! dx.doi.org/10.17504/protocols.io.n2bvjed5wgk5/v1

Why hasn't Preprint Peer Review caught on more?

I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.

more in thread below!

Image of the job posting text as it appears on LinkedIn 🌟 We’re Hiring: Associate / Scientific Engagement Manager 📍 Location: New York or Jersey City (Hybrid) I'm excited to share that we're looking for an Associate Scientific Engagement Manager to join the protocols.io team at Springer Nature This is a fantastic opportunity for someone to lead outreach and engagement efforts across the global research community—hosting webinars, collaborating with institutions, and supporting researchers in adopting protocols.io to improve reproducibility and accelerate discovery. 🔬 If you have a background in research, love science communication, and thrive in collaborative environments, we’d love to hear from you!

We're hiring at protocols.io (@protocolsio.bsky.social) in NY or Jersey City - Associate Scientific Engagement Manager

See LinkedIn post for more info & feel free to message me: www.linkedin.com/posts/eganle...

Use as Directed? A Comparison of Software Tools Intended to Check Rigor and Transparency of Published Work The causes of the reproducibility crisis include lack of standardization and transparency in scientific reporting. Checklists such as ARRIVE and CONSORT seek to improve transparency, but they are not ...

"proliferation of LLMs has prompted many people without experience to start creating [screening] tools...Simpler approaches often perform better [and] LLM results may not be reproducible...The fact that you can use an LLM doesn’t mean that you should." www.arxiv.org/abs/2507.17991
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Why you should sequence your plasmids (and how to do it for free) Through GetGenome, scientists in 100 countries can access free whole-plasmid sequencing — removing barriers, improving quality control…

We just published: Why you should sequence your plasmids (and how to do it for free)

Through @GetGenome scientists in 100 countries can access free whole-plasmid sequencing —giving researchers the confidence to move their experiments forward.

medium.com/p/why-you-sh...

Debunking the Myth: Opossums Don’t Eat Ticks <p>Researchers have debunked a popular meme about Virginia opossums eating ticks. Careful analysis of opossum stomach contents (yes, the work of some researchers!) revealed many items, including worms...

Neither did I! Just randomly read
‪the awesome blog post from Professor Hennessy (@c-hennessy.bsky.social‬) outdoor.wildlifeillinois.org/articles/deb... and then wondered what ChatGPT and Copilot would say.

There's no evidence that opossums eat any ticks, but it's a common myth (www.sciencedirect.com/science/arti...).

I asked ChatGPT & Copilot, "Do opossums eat ticks?"

Both confidently: "yes, thousands per week!". I then prompted, "Isn't it a myth?" And both answered: "yes, it's been debunked!"

Network for Advanced NMR Materials SSNMR Data Acquisition Protocols The NAN Materials SSNMR Data Acquisition Protocols collection is part of the NAN Materials SSNMR Knowledgebase; a collection of resources, training and educational material, pul...

Protocols @nmrfam.bsky.social Alex Paterson, Network for Advanced NMR Materials (NAN) Solid-State NMR Data Acquisition Protocols V.2 www.protocols.io/view/network... #NMRchat #NMR 🧲

How do we correct preprints? Caveat emptor, revisions & withdrawals - what this means for the scientific record. My presentation to the National Academies 1/n vimeo.com/1102568612?s...

So, Elon Musk, a Silicon Valley technocrat, created DOGE with the supposed goal of increased government efficiency.

But what we got instead is an extra government entity that has inserted senseless chaos and waste and worsened the existing bureaucracy?

Bring structure to your research - protocols.io A secure platform for developing and sharing reproducible methods.

Author here to answer any questions. The full protocol is online at protocols.io and all codebooks on github

The U.S. has led the world in science since the mid-20th century for two reasons: funding & welcoming students and researchers from around the world. The Trump administration is destroying both advantages (1/2)

Comparative Analysis of Phage Profiles in Environmental Samples: Metagenomic Sequencing Versus Culture-Bas... Culture-based isolation of bacteriophages from wastewater relies on a limited set of laboratory‐cultivable host strains, causing it to recover only a small fraction of the tru...

Comparative Analysis of Phage Profiles in Environmental Samples: Metagenomic Sequencing Versus Culture-Based Isolation www.protocols.io/view/compara...

CRAFTseq Genetic studies have identified thousands of individual disease-associated non-coding alleles, but identification of the causal alleles and their functions remain critical bottl...

Happy to answer any and all questions about this work. We'd love to see more people try it.
Full protocol: www.protocols.io/view/craftse...
Full analysis: github.com/immunogenomi...

Re-using pipette tips for gel loading Gel loading tips can be reused for most applications; there’s REALLY no need to throw them away after a single use. In our labs, we routinely reuse tips when loading gels, onl...

Load gels? Use #zebrafish 🐟? Want to do more sustainable research w/out compromising science? We-G Gestri, K Turner, G Powell @stevewilsonlab.bsky.social-made these protocols. Yes, we use these in our @science.org+@nature.com papers.
www.protocols.io/view/re-usin...
www.protocols.io/view/washing...

Majority of fruit fly immunity studies can be replicated, huge analysis finds Verification of 50 years of data bolsters immunology research, but identifies “suspicious” papers that don’t hold up

Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science. www.science.org/content/arti...

The easiest publishing process ever! After testing & retesting this protocol adapted from a large-volume industry standard method, I finally clicked “Publish” over at @protocolsio.bsky.social today. Can recommend; would publish again!! 🌾 🍞 🧪

dx.doi.org/10.17504/pro...

Wow, that is a gorgeous protocol! Thank you for sharing it publicly!

🚨🚨 We just published a protocol for non-lethally measuring morphology in 3D in small aquatic organisms!! 🚨🚨 www.protocols.io/view/non-let...

The work was led by undergrad Daniela Granados 🎉🎉 and our collaborators include Najva Akbari, and Lauren O'Connell!

Last month we published our protocol for detection of beet yellows virus. Here it is!

RT-LAMP for BYV detection www.protocols.io/view/rt-lamp...

At @sheffielduni.bsky.social we're strongly pro-openness, but alas not when it comes to pigeons...

Identification of Corynebacteria of the diphtheriae Species Complex and detection of the diphtheria toxin g... This protocol describes a quadruplex real-time PCR (Dip4plex), performed with the Qiagen QuantiNova™ Multiplex PCR Kit, for simultaneous identification of Corynebacteria of th...

qPCR diagnosis of #diphtheria: you may be interested by our procedure, which is now widely used across European reference laboratories: www.protocols.io/view/identif... @EURLdiphtheriaPertussis thanks @chcrestani.bsky.social for releasing on protocols.io