Djamel Nehar-Belaid

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Infant immune systems respond differently to severe COVID-19 Infants show unique immune responses to COVID-19, differing from adults and children. New study may guide better treatments for severe infant infections.

Infants hospitalized with severe #COVID19 have different immune responses than adults or older children

@dnehar.bsky.social @jacksonlab.bsky.social

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SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses - Nature Communications This work identified immune signatures of COVID-19 including broad Interferon signatures that are unique to infants. Compared with infected adults, infants display similar Interferon signatures in mon...

www.nature.com/articles/s41...

10/10 Big thanks to all my co-authors, particularly Asunción Mejías (@StJude). I want to thank my mentors: Jacques Banchereau, Virginia Pascual ( @WCM), Duygu Ucar ( @thejacksonlab.bsky.social and Octavio Ramilo ( @stjuderesearch.bsky.social ) for their guidance and support.

GitHub - dnehar/Infants_Cov19: COVID-19 project COVID-19 project. Contribute to dnehar/Infants_Cov19 development by creating an account on GitHub.

9/10 The processed scRNA-seq dataset from our study is available in GEO: GSE206289. Fastq files are available in dbGAP: phs002655. Children/infants dataset (PMID:37776858): GSE239799. Adult dataset (PMID:33713619): GSE161918. Scripts from this study are here: github.com/dnehar/Infan...

8/10 Our results suggest that infants with severe COVID-19 exhibit significantly more robust interferon responses than adults. This implies that unlike adults with severe COVID-19, defective IFN responses do not seem to be a common feature in infants.

7/10 In a combined analysis of infants and previously sequenced adults (generated by @tsanglab.bsky.social lab; PMID:33713619), infants display a similar ISG signature in monocytes but a markedly enhanced ISG signature in T and B cells, which is consistent with infant specific immune features.

6/10 In collaboration with Adolfo García-Sastre and Teresa Aydillo @mountSinai, we showed that of 13 convalescent serum available following acute COVID infection 12 demonstrated IgG directed at SARS-CoV-2 antigens. We were not able to detect anti-IFN autoantibodies in this group of patients.

5/10 We observed higher % of ISGhi CD4+, CD8+, and NK T cells in the acutely infected patients than in controls, and it appeared that higher number of infants in this hospitalized cohort demonstrated ISGhi clusters compared to infants with mild disease described in a prior cohort (PMID:37776858).

4/10 We described increased % of ISGhi CD16+ monocytes in infected infants, which differs from finding in adults, where CD16+ monocytes were contracted (PMID: 32810438). Also, infants with COVID-19 exhibited contraction of several DC subsets.

3/10 We observed higher % of interferon-stimulated genes (ISG)hi CD14+ monocytes in infected infants than controls. Notably, ISGhi IL1B+ CD14+ mo were increased in infected infants, which is consistent with our previous observations in children with lupus (PMID:32747814 and PMID: 39378884).

2/10 Conducting research of this kind in 2m-old infants is challenging, particularly due to the limited blood volume available (< 2 ml). While the immune response to SARS-CoV-2 infection in both adults and children is well characterized, cases of hospitalized infants with severe disease remain rare.

1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa

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The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...

1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...

postdoc opportunity - join our team! · Verhaak Lab The Verhaak lab in the Department of Neurosurgery at the Yale School of Medicine is looking to recruit a postdoctoral associate who will help us develop new therapeutic approaches to treat patients wi...

We are looking to recruit new postdocs! Please check verhaaklab.com/archive/2025....

📣 Open computational PhD & Postdoc positions!

Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus

📢 Please RT (what's the bsky equivalent here?) and distribute !

👇A quick instruction on how to apply

Infants display reduced NK cell responses in RSV and increased inflammatory responses in SARS-CoV-2 infections
doi.org/10.21203/rs....

Over the past year I gave some lectures on AI and Immunology including the keynote at NIAID and GSK Palio Meeting. I've been asked about sharing my slides, here they are:

1. slides: zenodo.org/records/1425...

2. NIAID meeting report: rdcu.be/d1VRw

3. Related: www.dropbox.com/scl/fi/y67z0...

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Happy to have been part of such a nice study showing age related changes in mammary gland. Very important findings given that most breast cancers occur in older women. @jacksonlab.bsky.social #Aging #BreastCancer #ImmuneAging #Immunology #SingelCells

Wow ! What a fantastic news ! Good on MIT. Hope other institutions will fellow this landmark decision

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Congratulations ! 🎉

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Excited to share our latest preprint on "Immune perturbations induced by SARS-CoV2 in 2 months-old infants" #Immunology #COVID19 #SystemsImmunology #Genomics
www.researchsquare.com/article/rs-5...