Alexi Nott 🏳️‍🌈

🚨 Deadline for a PhD opportunity working on epigenetics and small vessel disease and dementia is this Fri!

Please share!

ℹ️ More information found here: lnkd.in/eviy2A5B
🗓️ Closing date: Fri Jan 9th, 2026
🔗 My research group's interests: nottgroup.com
📨 Email me applications using the links above.

Applications open for an exciting PhD opportunity to understand epigenomic vascular contributions of dementia with my group and Joanna Wardlaw, Axel Montagne, Abbas Dehghan, Fotios Koskeridis, Ioanna Tzoulaki.ℹ️ lnkd.in/eviy2A5B
🗓️ Closing date: Jan 09
📨 Email me directly

ℹ️ More information can be found here: lnkd.in/eviy2A5B
🗓️ Closing date: Friday, January 09, 2026

🔗 My research group's interests are: nottgroup.com

📨 Applicants should email me directly through the above links.

This is a unique opportunity to work collaboratively with Prof Joanna Wardlaw and @axelmontagne.bsky.social at the University of Edinburgh, and Prof Abbas Dehghan and Fotios Koskeridis with Prof Ioanna Tzoulaki at @imperialmed.bsky.social, @imperialsph.bsky.social School of Public Health.

We have an exciting PhD (VIDA DTC) opportunity at
@imperialbrains.bsky.social & @ukdri.ac.uk, funded by
@alzheimerssoc.bsky.social. This project will use epigenomic/multiomic approaches to uncover novel biomarkers and drugs for SVD, a major contributor to stroke and Alzheimer’s.
lnkd.in/eviy2A5B

A big thank you to the examiners, Prof David Owen and Prof Gonçalo Castelo Branco @gocastelobranco.bsky.social.

Kevin's work was published just last month. Check it out: lnkd.in/efJHhYNp

A super proud moment, Dr Kevin Ziegler, who defended his PhD. 🥂 🎓 🎉

Kevin used epigenomic approaches to understand genetic risk for neurodegenerative conditions.

His work has now led the lab to explore small vessel disease and vascular cell types!

@ukdri.ac.uk @imperialbrains.bsky.social

New study reveals how blood vessel cells shape dementia risk | Imperial News | Imperial College London A new study has revealed that the cells lining our brain’s blood vessels play a more significant role in dementia than previously understood.

A new study has revealed that the cells lining our brain’s blood vessels play a more significant role in #dementia than previously understood.

👉 Learn more: bit.ly/3Ly82k1

@nottalexi.bsky.social @imperialmed.bsky.social

@cp-neuron.bsky.social

Thank you Mikhail

🔬 New research 🔬

A study led by Dr Alexi Nott at UK DRI at Imperial finds that different brain-cell types are linked to genetic risk for dementia in distinct ways.

Read more here 👉 tinyurl.com/3f9rnurz

The cell type risk genes we identified were mostly disease specific indicating unique vascular and immune mechanisms across these pathologies. Lastly, we integrated gene expression analysis to prioritise repurposable drugs with genetic evidence for the treatment of AD.

Using nanoCUT&Tag epigenomic profiling and pcHiC chromatin conformation analysis we found AD genetic risk is mostly immune with some vascular enrichment, whereas small vessel disease, which is often comorbid with AD, is strongly enriched for blood vessel cell types.

Figure 1 showing the strategy to isolate nuclei from the brain including blood vessels and the epigenetic profiles of 6 major brain cell types.

Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...

And a big thank you to both the examiners, Prof Mike Johnson and Dr Lasse Sinkkonen.

Extremely proud of Dr Janis Transfeld, who defended her PhD. Janis' project was a heroic undertaking to profile the epigenome of in vivo human dopaminergic neurons, which she then leveraged to interpret Parkinson's risk variants. @jaenice.bsky.social @ukdri.ac.uk @imperialbrains.bsky.social 🎉🎓🍾

Really nice work from the @nottalexi.bsky.social lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, @mangiruben.bsky.social and Alexi 👏🏻✨

Thank you Hyejun!

A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾
journals.plos.org/plosgenetics... More to come from Aydan soon!

Many thanks to the excellent team on this, including @kittybmurphy.bsky.social , Yuqian Ye, Maria Tsalenchuk and @nottalexi.bsky.social 🙏🏻🙏🏻

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...

Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social

www.nature.com/articles/s41...

(Collaborative work with Panos Roussos and his team! )

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

@sj-marzi.bsky.social @annamallach.bsky.social @andreaserio.bsky.social

Wonderful evening with @liddelowsa.bsky.social following his visit to @imperialbrains.bsky.social @ukdri.ac.uk 🧠

@nottalexi.bsky.social we are looking forward to your presentation at #Neuroepi25 in Malta.🌞
Please share with your followers to let them know early bird registration & talk submission closes on 24 April 2025!
Find out more: bit.ly/42ls1an
#FusionNeuro

Massive congrats and gratitude to lead authors Leyla Abbasova, Paulina Urbanaviciute, Di Hu and Joy Ismail, as well as collaborators Brian Schilder, @nottalexi.bsky.social and Nathan Skene 🙏🏻🥰 It's been a long journey, but I'm so glad I got to share it with these excellent colleagues!

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences Applications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/).

Postdoc position #1 is live! Please apply / spread the word!

lms.mrc.ac.uk/work/vacanci...

Thank you for the invite, it was great to hear about the amazing science being done in the centre during my visit!

We are missing you already!