EGA archive

#DeCodingHEREDITARY
📚🛠️ Check out Deliverable 5.1: Visualization components for sequences, networks, text, and high- dimensional data.

🔬 It highlights the use of interactive data visualization and visual analytics to make sense of large, complex datasets. 

📥 https://zenodo.org/records/14628086

🌟 We are #hiring 🌟

Explore the open positions to join our team at the @crg.eu in Barcelona! Apply now:

🔹 Operations Technician: recruitment.crg.eu/content/jobs...
🔹 Operations Bioinformatician: recruitment.crg.eu/content/jobs...

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.

More info: www.crg.eu/en/content/t...

European network of trusted research environments (EOSC-ENTRUST) project EOSC-ENTRUST aims to create a European network of Trusted Research Environments (TREs) for sensitive data.

Tomorrow, Jordi Rambla, Team Leader of the EGA - @crg.eu, will participate in the #EOSC-ENTRUST Sustainability Workshop:

💬 Perspectives and lessons learned from #FederatedEGA and the Genome Data Infrastructure (GDI) project
📍 October 23, 15:40-15:55 CEST

More info: eosc-entrust.eu/news/eosc-en...

🎯 Today's #ELIXIRFridayReads is a paper 💡 focusing on financing models that support #dataresources and associated services in a long-term data infrastructure. Read more 👉 https://loom.ly/9UihRMg
@elixir-nl.bsky.social #ResearchInfrastructure

🧬💬 Tomorrow, Abeer Fadda, bioinformatics lead at the EGA - @crg.eu team and researcher in the @hereditaryeu.bsky.social project, will be participating in a roundtable on genomic medicine at #RIES2025

Check out the agenda ➡️ forumries.com/programa/

✨ Big week ahead for the HEREDITARY project!

🧬 #RIES2025 in La Toja, Galicia on October 15-16 with Abeer Fadda (EGA) and an HEREDITARY stand in the exhibition area.

🧠 #BIDays2025 in Brussels, where HEREDITARY will host a World Café.

🔍 https://acortar.link/zlqN2H

🚀 Yesterday we presented #EASIGEN-DS to the Federated Human Data Community of @elixir-europe.org

🎯 Ivo Gut, director of @cnag-eu.bsky.social, shared our vision for designing the European genomics infrastructure 🧬

Big thanks to Teresa D'Altri @egaarchive.bsky.social/@crg.eu for the invitation! 👏

Stay updated with the latest EGA news by signing up for the newly launched EGA Newsletter! 🤩

Providing easy access the latest highlights and insights from EGA including about #FederatedEGA, @ga4gh.org engagements, international projects, and more 🙌

✏️ Sign up here: mailchi.mp/4c1f9c3a3030...

Subscribe to the EGA newsletter

Don't forget to subscribe to get the next newsletter: mailchi.mp/4c1f9c3a3030...

The first EGA newsletter has been released!

🚀 Explore the #FederatedEGA timeline
🔎 Discover the EGA Allele Frequency Browser
💥 Check out the projects starting in 2025

And much more! Read the full newsletter here: mailchi.mp/dd9d965ca3a2...

Connect (8 to 10 October) Connect agenda (8 to 10 October)

Welcome to the start of the GA4GH Connect meeting!

Over the next three days, we will hold 30 collaborative sessions to advance GA4GH standards development and implementation, share insights and best practices, and brainstorm strategic actions as a community.

Join a session:

📢 We are excited to announce the incoming launch of the EGA Newsletter!

Sign up now to stay updated on the latest news related to Federated EGA, Beacon, along with highlights and updates on the ongoing projects we are involved in 🙌

👉 mailchi.mp/4c1f9c3a3030...

GA4GH Global Alliance for Genomics & Health (GA4GH) is a policy-framing and technical standards organization, working together for responsible, voluntary & secure sharing of genomic & clinical data for…

Welcome to day one of the GA4GH 13th Plenary meeting. We are excited to welcome attendees and viewers from around the globe.

Our Plenary live stream starts in one hour. Visit the GA4GH YouTube Channel to tune in to today’s programme:

Beacon Implementers Forum The GA4GH Beacon Implementers Forum aims to foster knowledge sharing and cross-community collaboration to support the integration and innovation of Beacon in research and clinical genomics. While…

🌐 Join the next GA4GH Beacon Implementers Forum meeting on Wednesday, 26 November at 14:00 UTC.

Learn more and register for the invite:

As part of the research, some of their sequencing data were deposited at the EGA. In this conversation, we explore their experience with data sharing 💡

Check out the interview in our latest blog post: blog.ega-archive.org/from-researc...

Mucosal Macrophages Govern Intestinal Regeneration in Response to Injury Macrophages regulate the recovery from radiation-induced enteritis by promoting intestinal stem cell regeneration, suggesting potential therapeutic targets to improve the quality of life for cancer pa...

To bridge this gap, we have talked with the Cell Plasticity and Regeneration Group at @idibell.bsky.social after their recent publication of the paper "Mucosal Macrophages Govern Intestinal Regeneration in Response to Injury" in Gastroenterology

🔗 www.gastrojournal.org/article/S001...

📣 New blog post alert!

This year, over 400 publications have cited data stored at the EGA, either for deposit or reuse. As a result, we are usually in contact with hundreds of users, but the truth is that we don't know as much about you as we would like!

The SOX11:SMARCA4 complex is a driver of oncogenic transcriptional programs in mantle cell lymphoma - Blood Cancer Journal Blood Cancer Journal - The SOX11:SMARCA4 complex is a driver of oncogenic transcriptional programs in mantle cell lymphoma

📍 The SOX11:SMARCA4 complex is a driver of oncogenic transcriptional programs in mantle cell lymphoma
📃 Published in Blood Cancer Journal @nature.com
🤝 Reused data: EGAS00001004165 & EGAS00001006613
🔗 www.nature.com/articles/s41...

Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition - Nature Communications Tumor-associated neutrophils exhibit heterogeneity in breast cancer. Here, the authors identify a distinct precursor population (PreNeu) in estrogen receptor-positive tumors. PreNeu suppress homologou...

📍 Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition
📃Published in Nature Communications
🤲 Deposited data: EGAS00001008154
🔗 www.nature.com/articles/s41...

Chronological age estimation from human microbiomes with transformer-based Robust Principal Component Analysis - Communications Biology An interpretable Transformer-based model accurately predicts chronological age across body site and identifies key microbial signatures of aging.

📍 Chronological age estimation from human microbiomes with transformer-based Robust Principal Component Analysis
📃 Published in Communications Biology @natureportfolio.nature.com
🤝 Reused data: EGAS00001005020
🔗 www.nature.com/articles/s42...

Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma - Molecular Cancer Background We previously identified an oncogenic role for the transcription factor HNF1A in pancreatic ductal adenocarcinoma (PDAC). However, the role of HNF1A in the metastatic progression of PDAC re...

📍 Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma
📃 Published in Molecular Cancer @springernature.com
🤝 Reused data: EGAS00001002543
🔗 molecular-cancer.biomedcentral.com/articles/10....

📍 Detection of Brain Cancer Using Genome-wide Cell-free DNA Fragmentomes
📰 Published in Cancer Discovery @theaacr.bsky.social
🤝 Reused data: EGAS00001007249
🤲 Deposited data: EGAS50000000986
🔗 aacrjournals.org/cancerdiscov...

Data reuse can boost the potential of any dataset, even during summer 😎☀️! From time to time, we highlight some of the latest papers featuring deposited data at the EGA or reused data from the Archive 👀

Check out our latest compilation 🧵↘️

💡Did you know? The EGA stores 15+ PB of biomedical data from 20+ countries, spanning studies on cancer, neurodegeneration, and more. As of 2025, over 400 publications have cited its 12,000 datasets for research and reuse.

🔔 𝐒𝐭𝐚𝐲 𝐭𝐮𝐧𝐞𝐝 𝐭𝐨 𝐦𝐞𝐞𝐭 𝐭𝐡𝐞 𝐞𝐧𝐭𝐢𝐫𝐞 𝐂𝐨𝐧𝐬𝐨𝐫𝐭𝐢𝐮𝐦!

#EASIGEN #CRG #HorizonEU

🔬 CRG co-hosts the @egaarchive.bsky.social with EMBL-EBI, supporting secure storage and sharing of sensitive biomedical data. CRG team has expertise in different areas:

🔹Genomic data management
🔹Bioinformatics infrastructure and tools
🔹ELSI
🔹Collaborative research and innovation

📢 Meet the partners of the #EASIGEN-DS Consortium!

📍 @crg.eu is a biomedical research hub driving innovation in life sciences. Based at the PRBB, they specialise in genomics, systems biology, and computational biology. In #EASIGEN-DS, they serve as the expert node for data and data management

Excellent news, and shows the progress - and flexibility - of FEGA in providing a mechanism for federated discovery and access of controlled access human genomic data, consistent with national legislation and ethics.

With the signing, the network now comprises 9 national nodes, hosting a total of 37 federated datasets available for reuse 🚀🧬 If you are looking for information on how to join the #FederatedEGA, take a look here:

👉 ega-archive.github.io/FEGA-onboard...

Switzerland joins the Federated European Genome-phenome Archive (FEGA) Following the successful demonstration of secure infrastructure for storing and sharing sensitive patient data, Switzerland has now officially joined the Federated European Genome-phenome Archive (FEG...

We are celebrating the joining of Switzerland to #FederatedEGA as a national node, after the signature of the Collaboration Agreement with the @sib.swiss!

More information ↘️ www.sib.swiss/news/switzer...