Luiz G Gardinassi

Happy to become an Associate Professor of Pathology @uspoficial.bsky.social

Substâncias isoladas de esponjas marinhas mostram potencial para tratar malária Em testes pré-clínicos conduzidos na USP de São Carlos, compostos denominados batzelladinas foram eficazes até contra cepas de <i>Plasmodium</i> resistentes aos antimaláricos convencionais

Em testes pré-clínicos conduzidos na @uspoficial.bsky.social de São Carlos e descritos em ACS Infectious Diseases, compostos denominados batzelladinas foram eficazes até contra cepas de Plasmodium resistentes aos antimaláricos convencionais. agencia.fapesp.br/54692

Entrevista com João Setubal | Centro de Memória FAPESP Entrevista com professor titular do Departamento de Bioquímica do Instituto de Química da USP João Carlos Setubal .

Em entrevista ao Centro de Memória #FAPESP, o professor titular do IQ-USP João Carlos Setubal conta como a bioinformática deu suporte ao projeto Genoma FAPESP e lembra a publicação do artigo sobre o sequenciamento da Xyllela fastidiosa em Nature, em 2000. centrodememoria.fapesp.br/ciencia-e-vo...

Saúvas reconhecem e combatem patógeno mesmo 30 dias após a primeira contaminação, mostra estudo Características de memória imune social foram observadas por pesquisadores da Unesp e colaboradores em colônias de formigas-cortadeiras expostas a quatro diferentes fungos patogênicos

Características de memória imune social foram observadas por pesquisadores da Unesp e colaboradores em colônias de formigas-cortadeiras expostas a quatro diferentes fungos patogênicos. agencia.fapesp.br/sauvas-recon...

The NIH’s Most Reckless Cuts Yet Ending clinical trials with no warning can put patients at risk.

'Among those NIH-funded projects are more than 100 clinical trials that now may be forced to halt abruptly, agency officials told me. And those officials expect further orders to cancel hundreds more.'

Entrevista com Mayana Zatz e Helena Nader | Centro de Memória FAPESP Entrevista com a bióloga molecular Mayana Zatz, coordenadora do Centro de Pesquisas sobre o Genoma Humano e Células-Tronco (CEGH-CEL) e com a biomédica Helena Nader, presidente da Academia Brasileira ...

Em entrevista ao Centro de Memória #FAPESP, a biomédica Helena Nader e a bióloga molecular Mayana Zatz falam sobre discriminação de gênero, carreira de pesquisa e da militância apaixonada de ambas na política para a ciência. centrodememoria.fapesp.br/ciencia-e-vo...

How to communicate the value of curiosity-driven research The burden of proof is on us, as researchers, to explain why what we do is valuable to society.

'Skeptics often push back and question why, if basic science is so valuable, we can’t just count on companies—startups and big pharma—to fund it. The answer here is that only government and nonprofit funding can truly support the long arc of scientific discovery.'
@tonyzador.bsky.social

A call for the United States to continue investing in science | mBio The U.S. life science research mission is critical not only to human health and understanding the natural world but also to agriculture and food production, technological innovations, socioeconomic pr...

From the editors of @asm.org journals, a call to action!

Below we discuss the U.S. scientific research enterprise and provide evidence and arguments we hope the ASM community can use to advocate for science.

journals.asm.org/doi/10.1128/...

It is worth paying close attention to the new bill "Dangerous Viral Gain of Function Research Moratorium Act" introduced by Senator Roger Marshall.

If enacted, it will effectively stop all of virological research, including for vaccines.

www.marshall.senate.gov/wp-content/u...

🧵👇

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

#Macrophages literally eat and live of dead #bacteria, while live bacteria stimulate inflammation. 🦠 viability is sensed by an mTORC1 metabolic switch.

Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social

www.nature.com/articles/s41...

So - I've actually led Ebola outbreak response at USAID.

This is bunk from Elon. They have laid off most of the experts, they're bankrupting most of the partner orgs, have withdrawn from WHO, and muzzled CDC.

What's left is a fig-leaf effort to cover their asses politically.

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!

www.nature.com/articles/s41...

Transposable elements may enhance antiviral resistance in HIV-1 elite controllers - Genome Biology Background Less than 0.5% of people living with HIV-1 are elite controllers (ECs)—individuals who maintain undetectable plasma viremia without antiretroviral therapy, despite having replication-compet...

Feels awkward but necessary to celebrate scientific progress in this imperiled time for US biomedical research.

Proud of our latest paper out today exploring the role of transposable elements in antiviral resistance to HIV 🦠

genomebiology.biomedcentral.com/articles/10....
🧵1/n

Proteína de bactéria que vive entre o solo e pilhas de bagaço de cana pode aumentar produtividade do etanol de segunda geração Qual seria o lugar com maior probabilidade de haver microrganismos especializados em quebrar a parede celular da cana-de-açúcar, descontruir a celulose, um carboidrato longo que dá rigidez às plantas ...

Proteína de bactéria que vive entre o solo e pilhas de bagaço de cana pode aumentar produtividade do etanol de segunda geração bit.ly/4hEYPBC

#bioenergia #canadeaçúcar #etanol

What are the best AI tools for research? Nature’s guide There are many large language models to choose from; some excel at coding, whereas others are better for synthesizing information.

There are many large language models to choose from; some excel at coding, whereas others are better for synthesizing information

https://go.nature.com/4hGYf6q

Em estudo pré-clínico, novo soro antiveneno de jararaca foi três vezes mais eficiente. Pesquisadores da Unifesp e do Instituto Butantan trabalham em versão com mais anticorpos neutralizantes e menos proteínas associadas a efeitos colaterais| agencia.fapesp.br/53941

The ingredients of a great scientific lecture | EMBO reports EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

'Bob’s true test of a perfectly structured presentation was that the speaker should be able to ditch the PowerPoint slides and successfully deliver the same message using only the blackboard (...) most talks would indeed be better when boiled down to the bare basics: chalk board, presenter, ideas.'

Women’s History Month: Tu Youyou Tu Youyou is a Chinese pharmaceutical chemist whose unique training in the classification of medical plants and their active ingredients resulted...

Malaria once seemed unstoppable—until Dr. Tu Youyou’s research turned the tide saving millions of lives and earning her a Nobel Prize in 2015. 🦟🌿💊 How different would global health be without her groundbreaking research? How many lives has she saved? #WomenInHistory #WomenInSTEM
tiny.cc/gib9001

YouTube video by Agência FAPESP Ciência SP | Controle glicêmico reduz declínio da mobilidade em idosos com diabetes

#CiênciaSP | Estudo conduzido na @ufscar.bsky.social com 3.202 idosos mostrou que controle da glicemia em diabéticos é capaz de amenizar o declínio da velocidade de marcha, processo do envelhecimento associado à perda de independência e ao risco de quedas www.youtube.com/watch?v=5cy7...

Neuromodulação pode ajudar na avaliação de atletas de esportes de colisão Jogadoras de Rugby Sevens participaram de estudo da USP sobre atividade cerebral após períodos prolongados de estresse e repetidos impactos na cabeça​

Neuromodulação pode ajudar na avaliação de atletas de esportes de colisão

Jogadoras de Rugby Sevens participaram de estudo da USP sobre atividade cerebral após períodos prolongados de estresse e repetidos impactos na cabeça​

jornal.usp.br/ciencias/neu...

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...

#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance

Diagram titled granulocytes, showing vector art images of a neutrophil, eosinophil, basophil and mast cell

Happy new year folks! I've made some more free vector art at scidraw.io hope these help with your fresh presentations and figures 🤓
#SciArt #immunosky #immunology #microbiology 🧪

Could you add me please, thank you!

The type 2 immune response in gut homeostasis and parasite transmission in malaria Malaria predisposes to concomitant bacteremia, resulting in increased mortality risk. Previous studies indicated that malaria causes structural changes in the intestine, induces tolerogenic immune responses, inhibits neutrophil recruitment, suppresses innate synthesis of IFN-γ, dysregulates mast cells (MCs) and basophils, and induces Th2-type immune responses. These can reduce parasite control while increasing enteropathogenic dissemination. Moreover, there is growing evidence that Th2 immunity, while protecting the host from overwhelming inflammation, may also contribute to increased parasite transmission. This review explores the roles of the regulatory immune response in bacterial coinfections and parasite transmission in malaria.

Our brand new review on type 2 immunity in malaria with terrific colleagues Renee Tsolis and Adrian Piliponsky highlighting the roles of mast cells and basophils in orchestrating the host response to infection and parasite transmission to Anopheles mosquitoes.

Doença de Alzheimer é mais comum em brancos e demência vascular afeta mais negros As duas principais formas de demência – a doença de Alzheimer e a demência vascular – não atingem brancos e negros no Brasil de maneira uniforme. Em ambos os grupos, o Alzheimer é a enfermidade que co...

Doença de #Alzheimer é mais comum em brancos e #demência vascular afeta mais negros. A conclusão resulta de estudo que analisou 16 áreas do cérebro de 1.815 pessoas que morreram na cidade de São Paulo. bit.ly/3DjWNre

#neurologia #medicina #saúdepública

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer&nbsp;indirectly via metabolite transfer.

"Tumours in mice supplemented with fructose consistently grew faster than tumours in control animals. Taken together, these data demonstrate that dietary fructose increases tumour growth in multiple different tumour models."

www.nature.com/articles/s41...

Great! Could you add me please? Thanks!

This year, the term “scientist” turns 190 years old!
It was coined by William Whewell, who also considered the alternatives:
“savant”,
“philosopher”,
“nature-poker”, and
“nature-peeper”
Did he choose the right one?

Quote on a red background stating, "... the work to fight HIV/AIDS is far from over." Attributed to H. Holden Thorp, Editor-in-chief, Science journals.

"In naming ... lenacapavir as the 2024 #BOTY, Science acknowledges the next, but by no means final, step in the drive to fight HIV/AIDS, where the rigors of the laboratory and the needs of humanity are inseparable," writes @holdenthorp.bsky.social in this week's #ScienceEditorial. scim.ag/4g9kjG4