Frank Zaucke's Avatar

Frank Zaucke

@fzaucke.bsky.social

Head of a reserach lab at the University Hospital Frankfurt, Goethe University. Interested in the role of the #cartilage and #bone #extracellular #matrix in common and rare skeletal diseases, in particular #osteoarthritis and #osteogenesis imperfecta

353 Followers  |  258 Following  |  25 Posts  |  Joined: 17.11.2024  |  1.9699

Latest posts by fzaucke.bsky.social on Bluesky

Post image

Our next @change-ecm.bsky.social abstract is by Giulio Gatto, a PhD candidate from @goetheuni.bsky.social. Giulio is investigating OA-associated changes in cartilage ECM under the supervision of @fzaucke.bsky.social. Please message Giulio if you'd like to know more. www.linkedin.com/in/giulio-ga...

30.10.2025 13:51 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Amazing! Thanks for this great overviewπŸ‘πŸ˜Š

22.09.2025 12:27 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Fantastic line-up of speakers!
If you are interested in matrix research, please come to HeidelbergπŸ€—

11.09.2025 10:29 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Congratulations BlandineπŸ€²πŸ‘πŸ«ΆπŸ‘all the best πŸ€πŸ€for the entire family!

12.08.2025 07:10 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Emerging concepts and challenges in the development of disease-modifying osteoarthritis drugs – a more refined perspective

The final version of our recent review on challenges in the development of DMOADs is available hereπŸ‘

#osteaorthritis

rdcu.be/eAflJ

11.08.2025 14:24 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
Figure showing the building MatriComDB, an omnibus database of matrisome protein interactions.

Figure showing the building MatriComDB, an omnibus database of matrisome protein interactions.

Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess

16.07.2025 08:59 β€” πŸ‘ 9    πŸ” 8    πŸ’¬ 1    πŸ“Œ 0

Hi Sarah, I am hereπŸ˜‰
Huge congrats on this achievement.πŸ‘πŸ’ͺπŸ‘ Looking forward to making a small contribution😊

16.07.2025 05:39 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Great meeting! Hope to see many of you thereπŸ‘‡

16.06.2025 15:38 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Video thumbnail

🚨 1 Milliarde Euro wΓΌrde fehlen – was bedeutet das fΓΌr Forschung & Lehre an hessischen #Hochschulen? Unser PrΓ€sident Prof. Dr. Enrico Schleiff findet klare Worte zum aktuellen Entwurf des Hochschulpakts. Jetzt ansehen und teilen! #Hochschulpakt #GoetheUni #Hessen

13.06.2025 11:51 β€” πŸ‘ 18    πŸ” 7    πŸ’¬ 2    πŸ“Œ 1
Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research | Arthritis Research & Therapy

Please have a look at this recent review on #osteoarthritis.
Thanks to Mario Rothbauer and the entire team for letting me contribute!

rdcu.be/epH7q

06.06.2025 09:18 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image

Excited to share our latest work on a novel mutation in a gene that causes non-classical OIπŸ‘‡

url:https://academic.oup.com/jbmrplus/article/doi/10.1093/jbmrpl/ziaf083/8128480

14.05.2025 13:47 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Please have a look at and enjoy reading the latest publication I have contributed toπŸ˜‰

01.04.2025 10:11 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Congrats, Catherine!

13.03.2025 15:32 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals To investigate the effects of 21 days bed rest immobilization (with and without exercise and nutrition intervention) on serum concentrations of cartil…

Now, the same group (including myselfπŸ˜‰) presents data on how other cartilage biomarkers are changed as a result of immobilization.

Immobilization by 21-days of bed rest causes changes in biomarkers of ... www.sciencedirect.com/science/arti...

12.03.2025 15:22 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Immobilization by 21Β days of bed rest results in type II collagen degradation in healthy individuals To investigate the effects of 21 days of bed rest immobilization (with and without exercise and nutrition interventions) on type II collagen biomarker…

In 2024, the effect of immobilization (by a 21 day bed rest) on the degradation of collagen II was published in the journal Osteoarthritis and Cartilage by Liphardt et al.

Immobilization by 21 days of bed rest results in type II collagen degr... www.sciencedirect.com/science/arti...

12.03.2025 15:19 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image

Honoured to be invited to such a fantastic meeting!

28.02.2025 08:06 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1

Congrats, Tom! Matrix rulesπŸ’ͺ☺️

29.01.2025 07:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I'll be thereπŸ‘‡πŸ˜‰

22.01.2025 11:34 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image

Are you attending the annual meeting of the Orthopaedic Research Society #ORS2025 meeting in Phoenix?
If soπŸ‘‡

18.01.2025 12:23 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image

With the following link
authors.elsevier.com/c/1kPnD3Im5h...
you have free access (for 50 days) to a recent study that our lab contributed to. We thank the lead authors for involving in this exciting project.

16.01.2025 08:00 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Amazing study!πŸ‘‡

14.01.2025 07:24 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Congratulations! Very nice imagesπŸ‘

03.01.2025 19:39 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Post image

In case you are interested in the role of the #ECM in inherited skeletal disorders other than #osteogenesis imperfecta like e.g. #Marfan or #Ehlers-Danlos, #achondroplasia, #ciliopathies: watch out for this book that will be published soon (January 2025)!

17.12.2024 12:19 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1
Preview
Osteogenesis imperfecta: shifting paradigms in pathophysiology and care in children The formation of functional bone requires a delicate interplay between osteogenesis and osteolysis. Disturbances in this subtle balance result in an increased risk for fractures. Besides its mechanica...

🚨publication alert🚨 Open Access!
Please have a look at our latest review:
doi.org/10.1515/jpem...

14.12.2024 18:31 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Post image

Spectacular view of #Cologne yesterday evening

04.12.2024 07:40 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image

A very dark bluesky yesterday evening in Frankfurt

27.11.2024 15:12 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image

A more detailled summary of my research interests/activities....generated here: scholargoggler.com

22.11.2024 09:37 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Osteoarthritis year in review 2024: Biology Osteoarthritis (OA) research is a fast-growing and extremely wide field, in which a substantial increase in knowledge has been achieved over the last year. It covers many different topics, however, a ...

My first post on bsky☺️
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...

21.11.2024 12:33 β€” πŸ‘ 15    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

@fzaucke is following 20 prominent accounts