Caldas Lab

Fantastic to have our paper:
www.cell.com/cell-reports...,
in this special issue of @cp-cellrepmed.bsky.social on #TME!
@kevinjtu.bsky.social from @caldaslab.bsky.social used deconvolution of bulk RNA expression to characterise the TME of 15,000 breast cancers!!

The relevance of tumor microenvironment for clinical outcomes in breast cancer Fondazione Gianni Bonadonna

A new study identifies 7 tumor microenvironment types and shows how they can shape therapeutic response, recurrence and metastases development in breast cancer
fondazionebonadonna.org/en/the-relev...
#FondazioneBonadonna #Oncology #CancerResearch
@mauriziocallari.bsky.social #Bianchini #Criscitiello

1/2 Our update of the PREDICT breast prognostic and treatment benefit model is now published by BMC Research Notes.

rdcu.be/ePXTJ

PREDICT is free and an extremely helpful clinical aid!
@paulpharoah.bsky.social deserves 👏

Great to see our paper posted @bsky.app by @cp-cellrepmed.bsky.social!
This was the work of @kevinjtu.bsky.social while an MSc student @caldaslab.bsky.social!
Thanks to @stephensammut.bsky.social and @ruedalab.bsky.social our amazing collaborators!
Walking the walk always! Not talking the talk...

Great to see @caldaslab.bsky.social work highlited im @genomeweb.bsky.social!
Great paper from @kevinjtu.bsky.social in latest @cp-cellrepmed.bsky.social!! 👏 👇
www.cell.com/cell-reports...
Thanks:
@ruedalab.bsky.social
@stephensammut.bsky.social
@ims-mrl.bsky.social
@hebrewuniversity.bsky.social

Please have a look at our recent work from the @caldaslab.bsky.social done by the amazing @kevinjtu.bsky.social !

Fantastic work by @kevinjtu.bsky.social done as MSc @caldaslab.bsky.social in collaboration with @ruedalab.bsky.social and @stephensammut.bsky.social. #TME deconvolution in 15,000 breast cancers! #METABRIC
@ims-mrl.bsky.social @hebrewuniversity.bsky.social @lautenbergc.bsky.social
🥳🥳👍👍💪💪

The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes Tu et al. present a systematic analysis of the tumor microenvironment across 14,837 breast cancers, identifying distinct cellular patterns that predict disease-specific survival independently of genom...

@caldaslab.bsky.social rocks!
@ims-mrl.bsky.social
@hebrewuniversity.bsky.social
@lautenbergc.bsky.social

The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes: Cell Reports Medicine www.cell.com/cell-reports...

My poor laptop wishes I learned how to use the cluster earlier, but it’s sacrifice was not in vain! We learned some important things about the breast cancer tumor microenvironment, described in our paper published today:
www.cell.com/cell-reports...

Here's the 🧵

PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer - Breast Cancer Research Introduction The aim of this study was to develop and validate a prognostication model to predict overall and breast cancer specific survival for women treated for early breast cancer in the UK. Methods Using the Eastern Cancer Registration and Information Centre (ECRIC) dataset, information was collated for 5,694 women who had surgery for invasive breast cancer in East Anglia from 1999 to 2003. Breast cancer mortality models for oestrogen receptor (ER) positive and ER negative tumours were derived from these data using Cox proportional hazards, adjusting for prognostic factors and mode of cancer detection (symptomatic versus screen-detected). An external dataset of 5,468 patients from the West Midlands Cancer Intelligence Unit (WMCIU) was used for validation. Results Differences in overall actual and predicted mortality were <1% at eight years for ECRIC (18.9% vs. 19.0%) and WMCIU (17.5% vs. 18.3%) with area under receiver-operator-characteristic curves (AUC) of 0.81 and 0.79 respectively. Differences in breast cancer specific actual and predicted mortality were <1% at eight years for ECRIC (12.9% vs. 13.5%) and <1.5% at eight years for WMCIU (12.2% vs. 13.6%) with AUC of 0.84 and 0.82 respectively. Model calibration was good for both ER positive and negative models although the ER positive model provided better discrimination (AUC 0.82) than ER negative (AUC 0.75). Conclusions We have developed a prognostication model for early breast cancer based on UK cancer registry data that predicts breast cancer survival following surgery for invasive breast cancer and includes mode of detection for the first time. The model is well calibrated, provides a high degree of discrimination and has been validated in a second UK patient cohort.

I am proud of this impactful work published 15 years ago. Led by @paulpharoah.bsky.social and now cited 300 times! Tool breast.predict.cam is widely used and free! Walking the walk... not talking the talk!
@caldaslab.bsky.social

breast-cancer-research.biomedcentral.com/articles/10....

Stay tuned for the next major paper from @caldaslab.bsky.social and @ruedalab.bsky.social led by @kevinjtu.bsky.social!
TME deconvolution from bulk RNA expression of nearly 15,000 breast cancers!!
@ims-mrl.bsky.social
@lautenbergc.bsky.social

Paper now accepted @cp-cellrepmed.bsky.social! 🎉🥳👏💪
Amazing @caldaslab.bsky.social!! So proud!

Amazing meeting about to start! @caldaslab.bsky.social continues to walk the walk!

With my dear friend James Brenton. @caldaslab.bsky.social knows no borders!

@helloeacr.bsky.social leads by walking the walk! Many just talk the talk...

Free speech rules to protect academic freedom come into force New legal duties on universities and colleges come into force, as government delivers Plan for Change to restore integrity of higher education.

@caldaslab.bsky.social applauds!

www.gov.uk/government/n...

Toward understanding and exploiting tumor heterogeneity - Nature Medicine In this Perspective, attendees of the Herrenhausen Tumour Heterogeneity meeting discuss the challenges in understanding tumour heterogeneity and propose ways forward for overcoming these hurdles.

10 years we contributed to this seminal perspective on tumor heterogeneity @naturemedicine.bsky.social! @caldaslab.bsky.social always walking the walk! Leadership in science is not about titles it is about contributions!

www.nature.com/articles/nm....

Sunset in Santa Cruz, Portugal.

Huge congratulations to our dear colleagues, Prof. Alexander Sigal and Prof. Carlos Caldas, on receiving the prestigious “Or” (אור) grant!
This national award supports the recruitment of world-class scientists to Israeli universities — and we are proud to have them as part of the Lautenberg Center.

30 years later!! The first demonstration that p16 was a tumor suppressor gene in primary human cancers (in this case pancreas). Continues to be cited! Proud of having done this! >1000 citations!!!

www.nature.com/articles/ng0...

31 years ago pioneering molecular diagnostics! Excellence in academia is not made of hollow 'leadership' titles! It is made by walking the walk as @caldaslab.bsky.social consistently does!!

aacrjournals.org/cancerres/ar...

Amazing new colleagues @hebrewuniversity.bsky.social and the Lautenberg Center!

Summer holidays for a Portuguese have to be by the beach!

Amazing coast of Portugal!

With friends from my Lisbon Medical School class!

3D tumour mapping Find a way of mapping tumours at the molecular and cellular level. This challenge was taken on by teams IMAXT and Rosetta.

Great to see @caldaslab.bsky.social work highlighted as it should! Always walking the walk! @cruk-ci.bsky.social

www.cancergrandchallenges.org/challenges/c...

Very proud! @caldaslab.bsky.social will continue to walk the walk!
An enormous thank you for all the support I have received from @hebrewuniversity.bsky.social and from @lautenbergc.bsky.social

Vagal blockade of the brain-liver axis deters cancer-associated cachexia Vagal dysfunction mediates the impact of tumor on liver metabolism, leading to cachexia. Blocking the right cervical vagus nerve with various invasive or non-invasive approaches alleviates cachexia, d...

Amazing story!!! @caldaslab.bsky.social applauds!

Vagal blockade of the brain-liver axis deters cancer-associated cachexia: Cell www.cell.com/cell/fulltex...

Monoclonal antibodies revolutionized biomedical science and health care The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.

One of the most important discoveries of the 20th century!

www.nature.com/articles/d41...