@mit.edu @harvard.edu

Nutrient requirements of organ-specific metastasis in breast cancer Nature - How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

Publication Alert @natureportfolio.nature.com 🚨 - Organ-specific breast cancer metastasis reflects complex nutrient–tumor interactions, not single metabolites. Purine synthesis is a conserved vulnerability. rdcu.be/eX1L7

🚨 New from our lab in @PNASNews: We developed a physiologically based model to optimize CAR-T therapy in solid tumors. Vascular normalization can cut CAR-T doses 5x & boost efficacy in tough tumors like glioblastoma & PDAC. www.pnas.org/doi/10.1073/... @mgbresearch.bsky.social

This work was recently published in PNAS by our team and collaborators. Read the full paper here www.pnas.org/doi/10.1073/...

Excited to share our recent discovery on combination therapy strategies to overcome treatment resistance in glioblastoma, now highlighted by
@MassGeneralNew @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...

Publication alert 🚨 Mutant p53 hijacks enhancers to drive CXCL1 expression and create an immunosuppressive TME in #PDAC. Targeting these enhancer-chemokine circuits could boost immunotherapy in PDAC. t.co/K84OB4NlOx #MGHCancerCenter #kochinstitute @harvardmed.bsky.social

Honored to see our Director, Dr. Rakesh Jain, recognized for his pioneering work in intravital microscopy and the tumor microenvironment. A true visionary in cancer research!
#AACR25 #TME #IntravitalMicroscopy

A window to cancer’s soul: the creation of intravital microscopy and the rise of the TME We discuss the tumor microenvironment and intravital microscopy with its inventor Rakesh Jain, a pioneer of the TME.

We caught up with the @theaacr.bsky.social Award for Lifetime Achievement in Cancer Research winner, Rakesh Jain (@harvardmed.bsky.social) to discuss his pioneering work in the tumor microenvironment and invention of the intravital microscopy imaging method.
www.biotechniques.com/cancer-resea...

New publication Alert! We developed a mathematical model to decipher how the gut microbiome shapes cancer immunotherapy response. Key insight: Microbiome composition influences immune cell activation & killing rates—critical for tumor control. @harvard.edu @mghsteelelabs.bsky.social

Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer - Nature Reviews Cancer Here Harkos et al. review the role of continuous models and discrete models in predicting and understanding therapy delivery and efficacy in solid tumours. They propose ways to integrate mechanistic a...

We review how mathematical modeling and AI can be combined to improve delivery & efficacy of molecular, nano, antibody & cellular therapies in solid tumors. www.nature.com/articles/s41... #TME #AIinOncology #CancerResearch @harvard.edu

Dr. Rakesh Jain of @mghsteelelabs.bsky.social shared insights from his decades-long work on vascular normalization—from concept to clinic. His lecture emphasized strategies to improve tumor vessel function and how these principles are transforming cancer therapy today.
#AACR2025 @harvard.edu