Vicki Jackson

Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects - Nature Genetics Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse p...

A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...

A sit in the sauna can save endangered frogs Anthony Waddle’s unconventional approach resulted in a stunningly practical solution to fight a deadly fungal infection.

A stack of bricks 🧱 or a luxury frog sauna? 🐸

Many species seek out these warm enclosures and, excitingly, regular visits on warm days can help fight against deadly chytrid fungus too. The fungus is sensitive to heat. ~28°C (82°F) is enough to limit chytrid growth 🧪🌏

www.nature.com/articles/d41...

A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵

Mark Thomas: how to define Nigel Farage – and trip up Ukip Paul Fleckney: The comedian and activist revisits the successes and dangers of his 100 Minor Acts of Dissent tour

Around 10 years ago, we saw Mark Thomas’ 100 acts of minor dissent show, where he pointed out that is obviously the correct pronunciation.
He also ran a comp to find the best new definition of farage: the liquid found at the bottom of a bin or waste container. 🤌

www.theguardian.com/stage/2014/m...

The decline in child mortality in many low- to middle-income countries in the last 30 years has been quite remarkable.

Ethiopia's rate fell from 20% to 5%.

Improvements in child mortality in rich countries look pretty meagre by comparison. But that's only when looking at it in absolute terms.

1/

This is mortifying. It's the kind of calculation you would normally make about a dictatorship.

open.substack.com/pub/christin...

Looks like a nice resource:
* Array genetic data for 80,638 Japanese children
* 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental)
* Parental environmental exposures

www.medrxiv.org/content/10.1...

How often are children genetically unrelated to their presumed fathers? Tackling a touchy subject, genetic detective finds only 1% of European children have unexpected paternity

How often is the man you think is your father ... not actually your genetic father? "Genetic genealogist" @maartenlarmuseau.bsky.social uses painstakingly researched family trees and Y chromosomes from modern men to find out how common extra-pair paternity really is. @science.org

Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels Nature Genetics - Rare variant association analysis of plasma proteins using whole-genome sequencing data in 54,306 individuals in the UK Biobank demonstrates that combining both single-variant and...

Excited to finally share that our paper looking at the effect of rare non-coding variants using WGS on circulating protein levels in the UKB has been released in Nature Genetics @naturegenet.bsky.social! We now analyse the full 3,000 circulating proteins in all 50,000 individuals rdcu.be/ea16i

TBtypeR: Sensitive detection and sublineage classification of Mycobacterium tuberculosis complex mixed-strain infections - Communications Biology TBtypeR enables detection of low-frequency mixed-strain Mycobacterium tuberculosis infections from whole genome sequencing data, outperforming existing methods and revealing a higher prevalence of mix...

TBtypeR enables detection of low-frequency mixed-strain Mycobacterium tuberculosis infections from whole genome sequencing data, revealing a higher prevalence of mixed-strain infections in analyzed patient datasets.
@jemunro.bsky.social @wehi-research.bsky.social

www.nature.com/articles/s42...

This work was in collaboration with Uni Washington - could even be the same group running the study you took part in!

Thanks for volunteering your time for research, I’m glad you found the experience worthwhile ☺️

Plus a nice write up in the Herald Sun!

www.heraldsun.com.au/health/condi...

Multi-omic spatial effects on high-resolution AI-derived retinal thickness Nature Communications - Retinal morphology is emerging as a key biomarker for disease. Here, using AI to create a high-resolution map of retinal thickness from optical coherence tomography images,...

Been a Bluesky lurker for a while now, time for a post!

New paper out today in Nature Comms @natureportfolio.nature.com on retinal thickness, spanning genetics, metabolite and disease associations 👀🧬 🖥️🧪

rdcu.be/d8Gcf

#genetics #gwas #retina