HoraniLab horanilab - Bluesky Statics

China turns the tables in biotech For at least a century, major scientific research initiatives have reliably occurred in the United States, usually in response to geopolitical competition. This helped establish the country’s status a...

This is a quick read summarizing what many of us have been seeing the past several years..

www.science.org/doi/10.1126/...

04.02.2026 16:09 — 👍 0 🔁 0 💬 0 📌 0

Merry Christmas to all my colleagues. I am thrilled to spend the holiday with a very very dear friend of mine, Dr Kareem Azab, from UT Southwestern. Drinking coffee as only a scientists might understand 😊

24.12.2025 19:04 — 👍 1 🔁 0 💬 0 📌 0

I was invited to give talks to 4 separate meetings the past 2 months. However, I am particularly excited to be invited by my former Chief, Tom Ferkol, to present at U of North Carolina. Together with my research mentor, now collaborator, Steven Brody, he is a main reason I work in cilia and PCD.

20.11.2025 15:22 — 👍 2 🔁 0 💬 0 📌 0

I am excited to share our latest preprint describing comparative transciptomic analysis between primary ciliary dyskinesia and cystic fibrosis. The more we understand the pathways driving disease the better equipped we are to find a cure.

www.biorxiv.org/content/10.1...

20.11.2025 15:05 — 👍 5 🔁 3 💬 0 📌 0

Machine Learning Analysis of Cilia-Driven Particle Transport Distinguishes Primary Ciliary Dyskinesia Cilia from Normal Cilia Rational. Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia and abnormal mucociliary clearance. Despite advances in understanding the pathogenesis of PCD, diagnos...

I am excited to share our preprint on the use of machine learning to identify abnormal cilia function. I am proud of Nicholas Hadas, a talented PhD candidate, for his hard work in compiling the code and preparing this manuscript.
www.biorxiv.org/content/10.1...

04.11.2025 14:09 — 👍 7 🔁 4 💬 0 📌 1

Guidelines in Focus - ERS Respiratory Channel Guidelines in Focus is a video interview series. Each new episode accompanies the release of an ERS or collaborative clinical guideline, statement or technical standard.

I would like to share a Guideline-in-Focus episode that summarizes the recently published ERS/ATS PCD diagnosis guidelines. These guidelines are an important step in standardizing our approach to #PCD diagnosis across the world.

channel.ersnet.org/channel-38-g...

08.10.2025 17:33 — 👍 1 🔁 0 💬 0 📌 0

European Respiratory Society and American Thoracic Society guidelines for the diagnosis of Primary Ciliary Dyskinesia Primary ciliary dyskinesia (PCD) is caused by pathogenetic variants in >55 genes. PCD is associated with early-onset chronic wet cough and rhinosinusitis, laterality defects, middle ear disease, and reduced fertility. The clinical presentation is heterogeneous, and diagnosis often relies on multiple tests. The American Thoracic Society (ATS) and European Respiratory Society (ERS) have previously developed separate guidelines for diagnosis. Here, ERS and ATS members systematically reviewed the literature on diagnostic tools used in practice and developed unified evidence-based guidelines for PCD diagnosis using GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology, and a transparent process of decision-making using Evidence-to-Decision (EtD) frameworks. The Task Force panel formulated three PICO (Patients, Intervention, Comparison, Outcomes) questions and three narrative questions. The accuracies of high-speed video microscopy (HSVM), immunofluorescence (IF), and nasal nitric oxide (nNO) were compared to a reference test of transmission electron microscopy (TEM) and/or genetics. The panel gives strong recommendation for use of HSVM, IF, and nNO as adjunct tests to TEM and/or genetics for PCD diagnosis. However, no adjunct test is suitable as a standalone test to diagnose PCD and no single adjunct or reference test is suitable to exclude PCD. Pursuing a genetic diagnosis is encouraged due to the implication on management. The panel emphasizes that tests should meet a minimum standard and proposes evaluation of patients at a referral centre experienced in diagnosis. The pretest probability based on symptoms should be considered when interpreting results.

I am excited to share the new PCD diagnostic guidelines.
A great collaboration with PCD experts from all over the world.

publications.ersnet.org/content/erj/...

26.09.2025 12:58 — 👍 4 🔁 2 💬 0 📌 0

It is bitter sweet to say goodbye to my patients. Last week was tough for the WASHU PCD and Rare lung team, as we saw 4 patients graduate to the adult side. I had the privilege to care for some for almost 15 years. I am glad to share their journey and be part of their lives.

26.09.2025 07:47 — 👍 2 🔁 0 💬 0 📌 0

Congratulations to the winner of the best poster awards and the best flash talks awards at the #OTM2025. Shout out to all the excellent posters on #primaryciliarydyskinesia #PCD.

22.08.2025 16:22 — 👍 0 🔁 0 💬 0 📌 0

PCD Foundation On The Move 2025 kicks off in Minneapolis. President Michele Manion welcomes an audience of 200! Exciting times ahead for #PrimaryCiliaryDyskinesia- registries, clinical trials and more! #OTM2025

20.08.2025 17:23 — 👍 1 🔁 2 💬 0 📌 0

Incredibly powerful patient panel to counter narrative that PCD is mild- importance of advocacy for care for their own health in a system where PCD is under appreciated. Burden of airway clearance & toll of school, family & work. Trade-offs choice of nebs, commitments & health trade-offs. #OTM2025

20.08.2025 19:56 — 👍 5 🔁 2 💬 0 📌 0

Time to celebrate.. the WASHU PCD Time is excited to see it's rank expand. We wish the expecting moms all the best, and we can't wait to meet the little ones.

27.06.2025 14:50 — 👍 1 🔁 1 💬 0 📌 0

Amazing accomplishment for Susan Dutcher. A well deserved and overdue recognition #NAS.

09.06.2025 16:29 — 👍 1 🔁 0 💬 0 📌 0

I am proud of Nicholas Hadas, a talented bioinformatician @horanilab.bsky.social @wu-ciliopathygroup.bsky.social (and a future PhD candidate) for wining first place in predictive analytics with his group, at the The CAIDF Hackathon in Chicago.

07.06.2025 03:00 — 👍 0 🔁 0 💬 0 📌 0

Dutcher elected to National Academy of Sciences Susan K. Dutcher, a professor of genetics and of cell biology and physiology at Washington University School of Medicine in St. Louis, was elected to the National Academy of Sciences in recognition of...

👏👏🙌
source.washu.edu/2025/05/dutc...

15.05.2025 15:55 — 👍 10 🔁 2 💬 0 📌 0

I am excited to welcome Shams Neupane, PHD to the Horani lab. I look forward to see what she can accomplish during her postdoc with us.

05.04.2025 15:54 — 👍 0 🔁 0 💬 0 📌 0

Looking forward to joining the ERN Lung meeting and discuss science and advanced in PCD with my European colleagues 😊

05.04.2025 15:52 — 👍 0 🔁 0 💬 0 📌 0

Genetic analysis explains rare disease severity, points to possible treatment Researchers at Washington University School of Medicine in St. Louis have uncovered why some patients with a rare genetic disorder called primary ciliary dyskinesia have worse lung problems than other...

Genetic analysis explains rare disease severity, points to possible treatment 👇 #ciliopathies #PCD

@dutcherlab.bsky.social @brodylab.bsky.social @horanilab.bsky.social @mahjoublab.bsky.social @washu.bsky.social

source.washu.edu/2025/03/gene...

12.03.2025 16:05 — 👍 6 🔁 2 💬 0 📌 0

World wide reach! WashU and our own Susan Dutcher were featured on the cover of Le Monte (Paris) during Stand Up for Science day.

11.03.2025 19:49 — 👍 10 🔁 3 💬 0 📌 1

So privileged to work with and alongside a group of thoughtful and amazing scientists at WASHU medicine as part of the @wu-ciliopathygroup.bsky.social with our fearless leaders @dutcherlab.bsky.social and @brodylab.bsky.social and motile cilia group @horanilab.bsky.social and @mahjoublab.bsky.social

23.02.2025 01:44 — 👍 7 🔁 1 💬 0 📌 0

Despite the uncertainties over science and research's future now adays, life needs to continue. The WASHU ciliopathy Research group and PCD and Rare lung disease center @washu Medicine is heading to a medical outreach mission to see PCD patients. #PCD #cilia

09.02.2025 16:32 — 👍 3 🔁 0 💬 0 📌 1

Steve wanted to relive his postdoc years.. we were glad to oblige : )

29.01.2025 21:53 — 👍 1 🔁 0 💬 0 📌 0

Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia architecture, and alter motility-independent cell functions.

Excited to share our recent work unraveling the effects of CCDC39/CCDC40 PCD variants on cilia. The result of years of work and collaborations of several members of the @wu-ciliopathygroup.bsky.social research group, lead by @dutcherlab.bsky.social and @brodylab.

www.science.org/doi/10.1126/...

29.01.2025 20:58 — 👍 2 🔁 1 💬 0 📌 0

Hello #Bluesky! We'd like to introduce ourselves...

We are the WashU Ciliopathy Research Group - a multidisciplinary team of investigators at Washington University in St Louis that perform fundamental, translational, and clinical research on #ciliopathies.

Follow us for updates from the group! 👇

17.01.2025 15:45 — 👍 67 🔁 20 💬 3 📌 1

Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibroc... bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

ACCEPTED! Great way to start a Monday.

Congrats to my amazing postdoc Tao Cheng!!!

Updated version of this coming soon: www.biorxiv.org/content/10.1...

13.11.2023 16:13 — 👍 2 🔁 1 💬 0 📌 0

Posts by HoraniLab (@horanilab.bsky.social)