Philip Hasel

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates, Cell Reports

"Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates"
http://dlvr.it/TPKJSH

@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025

Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications In this review, we discuss the development and maturation of inhibitory neurons and astrocytes and how early developmental activity in the brain might promote the interactions between these cell type...

Check out our new review article from my lab:

doi.org/10.1111/jnc....

Finally it’s here! 🌟⬇️

www.nature.com/articles/s41...

I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?

Really excited to announce that the Holt lab will be starting in January 2026 in the Center for Substance Use Research at Temple University Lewis Katz School of Medicine. Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions-DM or email me! l-holt-lab.com

UK Glia 2026 UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...

📢 June 8th-9th 2026 Bristol University 📢

We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.

Check out the exciting programme here:
www.physoc.org/events/uk-gl...

#neuroskyence #glia

Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”

This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.

🔗 www.cell.com/cell/fulltex...

Faust et al., Cell 2025

Hello world!
We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.

Astrocyte networks span large swaths of brain The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

www.thetransmitter.org/astrocytes/a...

Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1

Excited to share the preprint for one of my postdoctoral projects in the Nestler lab 🥳

So grateful to the @wellcometrust.bsky.social for investing in me... believing in me. It's hard to believe in yourself sometimes. Science is going really well and I am thrilled to be back in the lab

wellcome.org/research-fun...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com

So excited to see our work finally out today in Nature Communications! Brilliant summary by co-first author @sorayam.bsky.social below!

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

We used microglia replacement to understand the therapeutic and pathologic roles of macrophages in a genetic brain disease 🧠

A 🧵 on my first author work from the Bennett Lab (+ the paper) below! ⬇️

www.cell.com/immunity/ful...

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...

How does the brain repair myelin after injury?

We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...

Details below 👇

The brain’s “stalwart sentinels” express an unexpected gene The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.

A new study led by @philiphasel.bsky.social reveals the unique genetic profile of astrocytes that form the glia limitans superficialis (GLS), the thin layer of cells that covers the brain and spinal cord 🧠

Dr Hasel spoke to @thetransmitter.bsky.social about his work⬇️

Master class in single cell genomics analysis from @mrodea.bsky.social

I am #hiring an #MRI #physicist, please consider making an application. The job is based in #Sheffield, with extensive collaboration with #UCL. Opportunity to work at 7T & 9.4T, & undertake human imaging at 3T in parallel with the core preclinincal work.

jobsite.sheffield.ac.uk/job/Research...

The brain’s “stalwart sentinels” express an unexpected gene The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.

The cell bodies of astrocytes, not their end-feet, make up the brain’s last line of defense, a new paper in Cell Reports confirms. The findings flip the standard picture of these “stalwart sentinels” of the brain.

By Lauren Schenkman

www.thetransmitter.org/astrocytes/u...

The brain’s “stalwart sentinels” express an unexpected gene The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.

Great story covering our description of the superficial glia limitans!

@thetransmitter.bsky.social :

www.thetransmitter.org/astrocytes/u...

Home What is the UK Glia network? The UK Glia network has been founded by a group of scientists representing all fields of glia research. Our primary goal is to create a community for glia researchers work...

Have you seen our website:
Built and maintained by @drmyelin.bsky.social

Check it out 👀

www.glianetwork.org.uk

Highly recommend Aida and her lab! Apply for this amazing opportunity:

Varicose-projection astrocytes: a reactive phenotype associated with neuropathology Glial cells are fundamental for the pathophysiology of all neurological disorders. Astrocytes, the primary homeostatic cells of the central nervous system (CNS), exhibit species-specific characteristi...

🚨The first #preprint of the #FalconeLab is OUT!🥹🚨

We found that varicose-projection astrocytes are not a physiological type of #astrocytes but they are rather associated with neuropathology.

Read more here, feedback is welcome!!

More details👇👇
1/
www.biorxiv.org/content/10.1...

Sometimes you have to travel to find the cutting edge of glial biology... This meeting would definitely be worth the trip 👀

www.keystonesymposia.org/conferences/...

Multiregional blood-brain barrier phenotyping identifies the prefrontal cortex as the most vulnerable region to ageing in mice https://www.biorxiv.org/content/10.1101/2025.03.09.642233v1

Fresh off the press! We found that degeneration in one retina causes astrocytes to respond retinotopically across *both* hemispheres of the brain. Perhaps astrocytes across the CNS are able to coordinate their responses more than we anticipated... www.pnas.org/doi/10.1073/...