Melvin Sanicas, MD MSc MBA

NEW: #GLP1s may not just treat #diabetes & #obesity - they might reduce #addiction risk & severe outcomes across multiple substances. If #craving is the shared driver of addiction, targeting that pathway could reshape treatment. Now we need randomized #clinicaltrials www.linkedin.com/posts/drmelv...

Great work by Duke-NUS #Singapore researchers showing how #pancreaticcancer cells switch between treatment-sensitive and resistant states. Targeting the KRAS-ERK pathway to restore GATA6 and re-sensitize #tumors to #chemotherapy could be a promising strategy. www.linkedin.com/posts/drmelv...

By pairing a selectively evolved enzyme with an activatable probe, this @utokyoofficial.bsky.social imaging system reduces background fluorescence while highlighting #tumor tissue with high contrast. This could enhance intraoperative #cancer #surgery decision-making www.linkedin.com/posts/drmelv...

The “mini-heart” model by University of Technology Sydney is a great example of how 3D human tissue systems can reveal disease mechanisms that #cellculture miss. Understanding how #SARSCoV2 affects the #heart could be key to addressing long-term #COVID complications. www.linkedin.com/posts/drmelv...

Negative #clinicaltrials also matter. The STOMP study gives us clarity: #tecovirimat is safe but not effective for clade II #mpox. In #outbreaks, speed is critical but so is evidence. RCTs remain the gold standard for guiding real-world #publichealth decisions www.linkedin.com/posts/drmelv...

Promising findings by Hiroshima University researchers. In chronic #HepatitisB #HepB, #HBV #RNA may better predict #livercancer risk than current markers, even when viral DNA is undetectable. This could help identify patients who need closer monitoring earlier. www.linkedin.com/posts/drmelv...

Fascinating @monashuniversity.bsky.social research showing how a #tick protein can switch off harmful #inflammation. A single #evasin targeting multiple #chemokines could open new paths for treating RA, MS, #cancer & more. Nature still has a lot to teach us.
www.linkedin.com/posts/drmelv...

The key insight here is sensitivity. Solid tumors are heterogeneous, and #HITcells appear able to detect what #CARTcells miss. If finding the last #cancer cell is the problem, this work points to a potential solution.
www.linkedin.com/posts/drmelv...

Evolution leaves behind exploitable weak points. Targeting #PEX38 feels like #precisionmedicine for #parasites - smart, selective, and exactly the kind of thinking #neglectedtropicaldiseases like #Chagas disease need. www.linkedin.com/posts/drmelv...

NEW Karolinska Institute @ki.se study: #HPV #vaccination shows strong protection against #cervicalcancer for at least 18 years, with NO sign of waning #immunity. Early vaccination works. School-based programs save lives. Prevention matters. #FactsMatter #VaccinesWork
www.linkedin.com/posts/drmelv...

A “simple” #UTI can trigger #delirium and accelerate cognitive decline in older adults with #Alzheimers.
#Inflammation, especially IL-6, may be the link.
Early detection and treatment matter. #BrainHealth and immune health are deeply connected. www.linkedin.com/posts/drmelv...

よくやった #KumamotoUniversity! A great example of how #plantbiology can drive breakthrough biomedical insights - #pomegranate-derived compounds disrupting #disease-causing #amyloid deposits. Nature remains a rich source for #drugdiscovery.
www.linkedin.com/posts/drmelv...

NEW @cgdev.org #policy publication shows how routine #mpox #vaccination in endemic settings can deliver both local #health gains and global #pandemic protection, with returns that far exceed the upfront costs.
www.linkedin.com/posts/drmelv...

A Kenya–Uganda #clinicaltrial reduced new #HIV cases by 70% using #digitalhealth tools + community health workers. Prevention uptake (#PrEP/#PEP) increased 4x without new infrastructure. This is a scalable model for ending HIV globally. #CROI2026 www.linkedin.com/posts/drmelv...

Promising #EpsteinBarrVirus #EBV development @fredhutch.org: human monoclonal #antibodies #mAbs that block viral entry & protect humanized mice. Could be a big step toward preventing post-transplant lymphoproliferative disorder PTLD. #Immunology #TransplantMedicine
www.linkedin.com/posts/drmelv...

What’s striking about the gut–heart axis is how it reframes CVD as a systems problem - #microbes, #diet, immune signaling, and #metabolism all intertwined. It’s a reminder that prevention may depend as much on long-term microbial balance as on meds alone. asm.org/articles/202...

This reframes #vaccination as immune readiness not #pathogen-specific prediction, which can be transformative for #globalhealth. If the innate system can be safely “pre-primed”, this may close the gap between seasonal #vaccines & #pandemic preparedness. www.linkedin.com/posts/drmelv...

A large international study of nearly 1 million adults in the United States and Europe found that #diets linked to lower #inflammation and steadier #insulin levels are associated with a lower risk of #colorectalcancer. www.linkedin.com/posts/drmelv...

New research from University of Southern Denmark & Odense University Hospital suggests a previously undescribed #bacteriophage [#virus that infects #bacteria] inside Bacteroides fragilis is more common in #colorectalcancer patients. www.linkedin.com/posts/drmelv...

A reminder that fixing the root #physiology beats treating the symptoms, especially in chronic disease. Targeting #wound #hypoxia directly could transform chronic #woundcare and accelerate progress in #regenerativemedicine and organ engineering. www.linkedin.com/posts/drmelv...

A reminder that the risk for #mosquito borne diseases - like #chikungunya - is no longer confined to “tropical” temperature ranges. The #publichealth window is shifting, not just expanding, thanks to #climatechange. www.linkedin.com/posts/drmelv...

NEW study from Hopkins Kimmel Cancer Center showed that harmful #bacteria may fuel #breastcancer by activating SMOX, increasing #inflammation and DNA damage. SMOX inhibitors reduced #tumor growth/spread in preclinical models. www.linkedin.com/posts/drmelv...

Severe #influenza is not just a respiratory illness. New research shows the immune response to #flu #infection can damage the #heart, helping explain why heart attacks rise during #fluseason. Vaccination may reduce this risk. www.linkedin.com/posts/drmelv...

🐎✨ Happy #ChineseNewYear 2026! ✨🐎
Welcoming the #YearoftheHorse - a symbol of energy, #resilience, progress & bold new journeys. May 2026 bring: strength in action, speed with purpose & #success that moves forward 🧧🧧🍊🍊
#LunarNewYear #CNY2026 www.linkedin.com/posts/drmelv...

Major scientific breakthrough: researchers from @mcmasteruniversity.bsky.social @flindersuniversity.bsky.social and Universitätsmedizin Greifswald identified the molecular trigger behind the rare clotting syndrome VITT linked to #adenovirus exposure.

www.linkedin.com/posts/drmelv...

🦟 #Singapore tested a novel #dengue control strategy by releasing male Aedes #mosquitoes infected with #Wolbachia. After ~2 years, treated areas saw ~70% lower symptomatic #denguefever risk (6% vs 21%). Image by: Gustavo Monnerat.

www.linkedin.com/posts/drmelv...

🔬💉🌏 Honored to be featured by @themanilatimes.bsky.social (the #Philippines’ oldest existing newspaper) and recognized by CFO #PresidentialAwards #PAFIOO. The piece calls me a “global vaccine star,” but I’m simply a #lifelonglearner and student of #vaccinology. www.manilatimes.net/2026/02/09/d...

Honored to be admitted as a Fellow of the Academy of @medicaleducators.bsky.social (#FAcadMEd). This recognition reflects a career-long commitment to #science #communication #scicomm, #mentorship, and strengthening #medicaleducation to improve patient care. www.linkedin.com/posts/drmelv...

A very encouraging step forward in #HIV #research - strengthening natural killer cells to target hidden viral reservoirs could help move the field closer to long-term remission rather than lifelong treatment. www.linkedin.com/posts/drmelv...

This POSTECH study reinforces the idea that #vaccine effectiveness is shaped not only by antigen design but also by the host’s ecosystem, particularly the gut #microbiome. Metabolites such as butyrate as physiologic adjuvants could help improve mucosal vaccines. www.linkedin.com/posts/drmelv...