Santos lab

Thank you SO MUCH for having. Wonderful to talk to so many faculty and students and hear amazing science.

Outstanding talk today at #CABDseminars by Silvia Santos @santoslab.bsky.social! Silvia showcased the latest work understanding the deciding cellular signals during early human development. Silvia was hosted by Fernando Casares.
Thanks for coming Silvia!

Many congratulations Marta, Paola and co-authors!

Congratulations Isabela from the Dev Bio MSc program @imperialcollegeldn.bsky.social for finishing successfully your viva! Was an absolute pleasure to train you and have you in the lab! Beautiful work on cell cycle and fate and never ending enthusiasm! Best of luck with your next adventure!

EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026.
Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026

Couldn’t agree more!

Farewell dinner for @oliveringe.bsky.social with our wonderful Santos lab family. Ollie was our 1st Crick PhD student! Lots to celebrate and many fun memories. We are so grateful to have had Ollie in the lab and cannot wait to see what’s next for him in the Morris lab at Harvard! Best of luck,Ollie!

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

Amazing! 🤩

Super exciting! Congratulations! Look forward to reading it

Many congratulations David and team!

From stem cells to human development: supporting a growing field In 2014, Development organised the first of The Company of Biologists’ Journal Meetings: ‘From Stem Cells to Human Development’. Conceived to help bring together the developmental biology and stem cel...

It was fun to look back over a decade of 'From Stem Cells to Human Development' meetings at @dev-journal.bsky.social. This is one of the projects I most enjoyed during my time at the journal - and I really hope we helped to catalyse and support a community... journals.biologists.com/dev/article/...

I could not have summarised our article better than @katherine-brown.bsky.social!! Please see below and keep reading if you are interested in human embryo research policy. It was such a pleasure to write this piece with Susana, Mina and Catello.

Many congratulations @alexisbarr.bsky.social so well deserved! Congratulations to the whole lab! You guys rock!

Thank you @oliveringe.bsky.social, this is very sweet! I couldn’t have been more proud of the scientist (and colleague) you are!

This is Mirjam, Santos Lab’ PhD student presenting her work at the EMBL meeting on Developmental Metabolism 🫶. Conference was incredible and Mirjam had an amazing time!

Thank you very much Jesse!

2/3 Special thank you to my supervisor Silvia, her continued mentorship and support throughout the PhD and onto my next step. 🙏

1/3 After 6+ years at @crick.ac.uk I split my last cells and hung up my lab coat! Thank you to the brilliant community from fellow PhDs/Postdocs, LOAs, STPs, academic training team and to all past/present @santoslab.bsky.social members. My Crick journey would not have been the same without you all!

thanks so much Dafni!

Our ✨ latest work ✨ is out today! Led by our incredibly talented PhD student @oliveringe.bsky.social and with @jamesbriscoe.bsky.social and many @crick.ac.uk friends and collaborators. Very grateful to all involved, and excited about this story.

check out Ollie’s post www.cell.com/developmenta...

Many congratulations Pavel! To many more!! awesome pictures and awesome lab!

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

Mechanistic origins of temperature scaling in the early embryonic cell cycle - Nature Communications Researchers reveal mechanisms underlying non-Arrhenius temperature scaling of early embryonic cell cycle timing, using modeling, cross-species data, and reconstituted oscillations in frog egg extract.

www.nature.com/articles/s41...

Thanks for leading the way, James! To the next 25! Thank you for being such amazing neighbours

🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social

Welcome Cayley to the Santos Lab! Cayley is going to spend a year in the lab as part of her undergraduate degree! Cayley is interested in the interplay between cell cycle and fate

Congratulations Matilde! Look forward to reading it

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...

A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning

Everything from bistable switches & oscillators to phase portraits & more with Python code to explore

journals.biologists.com/dev/article/...