bioRxiv Cell Biology

Mammalian RAVE couples V-ATPase assembly to organelle acidification and function https://www.biorxiv.org/content/10.64898/2025.12.10.693398v1

Genetic identification of the RAS proteostatic machinery and its failure to regulate oncogenic variants https://www.biorxiv.org/content/10.64898/2025.12.10.693430v1

Adaptive Responses Directed by CREB Control Epithelial-Mesenchymal Plasticity in Cancer https://www.biorxiv.org/content/10.64898/2025.12.09.693241v1

A transition zone enriched WIF1⁺ basal cell subtype is associated with benign prostatic hyperplasia https://www.biorxiv.org/content/10.64898/2025.12.08.692826v1

Alveolar Type II Cell-derived MMP1high basal cells promote destructive microcysts in idiopathic pulmonary fibrosis. https://www.biorxiv.org/content/10.64898/2025.12.08.693033v1

Obesity reprograms adipose extracellular vesicles to induce muscle atrophy via miR-150-5p-mediated transcriptional silencing https://www.biorxiv.org/content/10.64898/2025.12.09.693129v1

Esc1-mediated anchoring regulates telomere clustering in response to metabolic changes. https://www.biorxiv.org/content/10.64898/2025.12.09.692953v1

Classifying Calcium Imaging Dynamics with Deep Learning: Multi-Frequency Analysis through Quantile-Based Time-Series Network Representations https://www.biorxiv.org/content/10.64898/2025.12.08.693018v1

IsoNet2 determines cellular structures at submolecular resolution without averaging https://www.biorxiv.org/content/10.64898/2025.12.09.693325v1

SLFN11 puts the brakes on Alternative lengthening of telomeres https://www.biorxiv.org/content/10.64898/2025.12.08.692725v1

GAS7 coordinates the activity of RAC1 and CDC42 to enhance macropinocytic surveillance and suppress motility in macrophages https://www.biorxiv.org/content/10.64898/2025.12.09.693239v1

Understanding the physiological behaviour of disc cells in an in vitro imitation of the healthy and degenerated disc niche https://www.biorxiv.org/content/10.64898/2025.12.09.693181v1

p16INK4A expression induces paracrine senescence via small extracellular vesicles https://www.biorxiv.org/content/10.64898/2025.12.09.689258v1

Cholesterol Remodeling by CH25h Rewires IFITM3 Trafficking and Secretion Without Enhancing Antiviral Restriction https://www.biorxiv.org/content/10.64898/2025.12.09.693135v1

Stability of orb mRNA in Drosophila ovaries is regulated by cis-regulatory elements in the three prime untranslated region and influences germ cell specification https://www.biorxiv.org/content/10.64898/2025.12.08.693029v1

Non-apoptotic death of the C. elegans linker cell is primed by MYRF-1 activation of pqn-41/polyQ https://www.biorxiv.org/content/10.64898/2025.12.08.693091v1

Plasticity of extrachromosomal DNA segregation during drug adaptation https://www.biorxiv.org/content/10.64898/2025.12.09.693337v1

EMCF ecosystem: Towards pretrained foundation model for electron microscopy image analysis https://www.biorxiv.org/content/10.64898/2025.12.09.693109v1

Structural Basis of Asymmetric Class C GPCR activation and distinct Gq coupling induced by force stimulation https://www.biorxiv.org/content/10.64898/2025.12.08.692793v1

Human umbilical cord mesenchymal stromal cells ameliorate ovarian damage and restore function in Premature Ovarian Insufficiency rat model https://www.biorxiv.org/content/10.64898/2025.12.07.692863v1

Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1

The Notch/snRNA negative feedback regulation and its implications in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2025.12.05.692707v1

EGO-like complex regulates TOR (Target of Rapamycin) activity and localization in Neurospora https://www.biorxiv.org/content/10.64898/2025.12.05.692677v1

Loss of Vitellogenin Receptor Function Results in Yolk Depletion, Virome Expansion and Reduced Bacterial Load Within the Oocytes of Rhodnius prolixus https://www.biorxiv.org/content/10.64898/2025.12.05.692514v1

Transport of endo-β-mannosidase AtEBM from cytoplasm to the vacuole through autophagy pathway in Arabidopsis https://www.biorxiv.org/content/10.64898/2025.12.09.693153v1

Nutrient/TOR signaling controls Mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila https://www.biorxiv.org/content/10.64898/2025.12.08.693086v1

Matrix Metalloproteinase (MMP) inhibition rescues endothelial glycocalyx damage and reduces neutrophil infiltration in sepsis-associated acute kidney injury https://www.biorxiv.org/content/10.64898/2025.12.04.691889v1

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1

The pathogenic mutant vimentin L387P disrupts endoplasmic reticulum organization and proteostasis https://www.biorxiv.org/content/10.64898/2025.12.07.692853v1

IL-13 Modulates Antiviral Effector and Proinflammatory Pathways in Rhinovirus-Infected Pediatric Bronchial Epithelium https://www.biorxiv.org/content/10.64898/2025.12.06.692776v1