König Lab

The iCLIP3 protocol was developed by Vlado Despic in a close and fun collaboration with @koenig-lab.bsky.social and @zarnack-group.bsky.social. The protocol was inspired by and successfully tested in the @embo.org #iCLIPcourse thanks to Elias Bechara, Chris Sibley and @rosario-avolio.bsky.social

Interested in G-quadruplex RNA structures, protein-RNA interactions, cooperativity, or splicing. Check out our latest study from our collaborative research center for polymer concepts.

@sfb1551.bsky.social @zarnack-group.bsky.social

Want to map protein-RNA interactions? Check out our new iCLIP3 protocol. Featuring steamlined library prep and visualisation of protein-RNA complexes without radioactivity! Bioinformatics workflow on top :)

With the Müller-McNicoll and Zarnack labs!
@zarnack-group.bsky.social @mixmue.bsky.social

YouTube video by Ignite Talks - Smart Ideas From Around the World Decoding mRNA: How AI & Vaccines Cure Cancer | Liana Lareau | Ignite Talk

This is my love letter to mRNA: an Ignite talk I gave as a fundraiser for the Lawrence Hall of Science. Custom mRNA cancer vaccines could be a game changer, but anti-science policies make their future so uncertain. www.youtube.com/watch?v=WUlu...

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social

Please get in touch if you have any questions.
www.nature.com/naturecareer...

I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

Congratulations!

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.

Working at HIRI At the HIRI, we do not just value excellent research. Short distances, an open door policy, and a good working atmosphere—this is what distinguishes us from others. Have a look at our current job…

🧬 Shape the future of #RNA-based infection research!
We are inviting applications for @helmholtz.de Junior Research Group Leader Positions (f/m/d). 👉 Apply by February 15 at www.helmholtz-hiri.de/en/jobs-tale...
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Congratulations Dr. Miona! Thank you for your amazing PhD work in the König Lab at @imbmainz.bsky.social and great to welcome you at the @uni-wuerzburg.de !

Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026.

Deadline: 4 May 2026

https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪

Eduardo Eyras appointed Director of Shine‑Dalgarno Centre for RNA Innovation | EMBL Australia From being recruited through a highly competitive international search to Centre Director, Professor Eduardo Eyras has charted an impressive journey at EMBL Australia. After joining the John Curtin Sc...

🔦 Spotlighting Prof @edueyras.bsky.social - EMBL Australia Group Leader & newly appointed Director of the Shine‑Dalgarno Centre for #RNA Innovation at ANU!

🔗 Read about his vision for the Centre:
www.emblaustralia.org/eduardo-eyra...

RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia - The EMBO Journal The distribution of N6-methyladenosine (m6A) controls its substrate RNA fate, playing key roles in various biological processes. However, the mechanism underlying site-selective m6A deposition of RNAs...

RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia
Tian-Qi Chen, Yu-Meng Sun, Shun-Xin Zhu et al
link.springer.com/article/10.1...

Why m⁶A? An RNA surveillance model Dierks and Schwartz discuss the m6A surveillance model, proposing that m6A flags “undesirable” intron-less RNAs (e.g., transposons) for decay. This provides a mechanism to distinguish “legitimate” spliced mRNAs and potentially suppress harmful RNA.

Online Now: Why m⁶A? An RNA surveillance model Online now:

SWARM is an AI framework for nanopore direct RNA sequencing that detects m6A, pseudouridine (Ψ), and m5C mods at single-nucleotide & single-molecule resolution.
Key innovation: Crosstalk-aware training with non-target mods & validated cellular signals to reduce false positives.
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🚀 Just published: New1 shields mRNAs from no-go decay — by preventing ribosome crashes at specific codons.
What’s new?
New1 (eEF3 homolog) stops ribosomes from stalling at C-terminal AAA/AGG/CGU codons. No New1 = collisions + Hel2 recruitment + Cue2-mediated no-go decay.

Congratulations, Marie!

Registrations are now OPEN! Join us in Newcastle for the “RNA in Physiology and Disease” conference, an international meeting bringing together world-leading RNA biologists and emerging researchers.

Early bird deadline: 1 May
Abstract deadline: 30 June
Register now: genetics.org.uk/events/rna-i...

Research Group Leader Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...

We are hiring for group leaders again — EBI is a great place to start your research group!

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

Many thanks to everyone who joined on Friday and made it such a memorable afternoon—we greatly appreciate the warm welcome in Würzburg! @cctb-wue.bsky.social @biologie-uniwue.bsky.social #WueBiT

Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner.

#piRNA #histone #mRNA #maternal #RNAbiology #RNASky

www.biorxiv.org/content/10.6...

🔊 Interested in doing a PhD on RNA-binding proteins in an abundant microbiota species and becoming a member of the German Priority Programme “Illuminating Gene Functions in the Human Gut Microbiome”? Apply here: www.uni-wuerzburg.de/karriere/sin...

a sign that says we 're hiring in orange on a white background ALT: a sign that says we 're hiring in orange on a white background

Nature Methods is hiring! We are looking for candidates with expertise in genetics, genomics and/or molecular biology to join our editorial team in the US (NYC/Jersey City) or China (Shanghai/Beijing). Apply by December 12!

springernature.wd3.myworkdayjobs.com/SpringerNatu...

ZAK activation at the collided ribosome - Nature The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫

www.nature.com/articles/s41...

A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/

Looking for your next career move in science? We are #hiring! Discover our latest job and #PhD opportunities!

#Jobs ➡️ bit.ly/irbjobs
PhD General call ➡️ https://bit.ly/3LtzIXi
PhD IRB DRIVE call ➡️ https://bit.ly/4hODx5B

#IRBJobs #ScienceJobs #Jobs #JobOffer #JobOffers #OncoSky #AcademicSky

🧪

Do you want to know more on what the PhD with us is about? 🙂
We are still looking for the perfect candidate! 🔎
Please spread the word! 🙏

Our new Cluster for Nucleic Acid Sciences and Technologies has kicked off in Eichstätt. NUCLEATE unites experts from Würzburg and Munich to advance nucleic acid science and develop future medical applications.
#NUCLEATE #RNA #DNA #Biomedicine
@uni-wuerzburg.de @lmumuenchen.bsky.social @tum.de

Regulation of RNA-binding proteins by small biomolecules Nature Reviews Molecular Cell Biology, Published online: 06 November 2025; doi:10.1038/s41580-025-00914-4RNA-binding proteins (RBPs) are essential for gene regulation. Recent data reveal that small biomolecules (SBMs) such as sugars, nucleotides, metabolites and drugs bind to RBPs and regulate their function. This Review discusses the landscape of SBM-binding RBPs, the molecular basis of their interactions and their relevance to human diseases.

New Online! Regulation of RNA-binding proteins by small biomolecules