König Lab

🔊 Interested in doing a PhD on RNA-binding proteins in an abundant microbiota species and becoming a member of the German Priority Programme “Illuminating Gene Functions in the Human Gut Microbiome”? Apply here: www.uni-wuerzburg.de/karriere/sin...

a sign that says we 're hiring in orange on a white background ALT: a sign that says we 're hiring in orange on a white background

Nature Methods is hiring! We are looking for candidates with expertise in genetics, genomics and/or molecular biology to join our editorial team in the US (NYC/Jersey City) or China (Shanghai/Beijing). Apply by December 12!

springernature.wd3.myworkdayjobs.com/SpringerNatu...

ZAK activation at the collided ribosome - Nature The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫

www.nature.com/articles/s41...

A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/

Looking for your next career move in science? We are #hiring! Discover our latest job and #PhD opportunities!

#Jobs ➡️ bit.ly/irbjobs
PhD General call ➡️ https://bit.ly/3LtzIXi
PhD IRB DRIVE call ➡️ https://bit.ly/4hODx5B

#IRBJobs #ScienceJobs #Jobs #JobOffer #JobOffers #OncoSky #AcademicSky

🧪

Do you want to know more on what the PhD with us is about? 🙂
We are still looking for the perfect candidate! 🔎
Please spread the word! 🙏

Our new Cluster for Nucleic Acid Sciences and Technologies has kicked off in Eichstätt. NUCLEATE unites experts from Würzburg and Munich to advance nucleic acid science and develop future medical applications.
#NUCLEATE #RNA #DNA #Biomedicine
@uni-wuerzburg.de @lmumuenchen.bsky.social @tum.de

Regulation of RNA-binding proteins by small biomolecules Nature Reviews Molecular Cell Biology, Published online: 06 November 2025; doi:10.1038/s41580-025-00914-4RNA-binding proteins (RBPs) are essential for gene regulation. Recent data reveal that small biomolecules (SBMs) such as sugars, nucleotides, metabolites and drugs bind to RBPs and regulate their function. This Review discusses the landscape of SBM-binding RBPs, the molecular basis of their interactions and their relevance to human diseases.

New Online! Regulation of RNA-binding proteins by small biomolecules

Starting your own lab is exciting—but challenging.
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉https://yi-workshop.gbm-online.de/yi-workshop-2.html

🧪 The #IRBBarcelona #PhD Call is now open! We are offering PhD #fellowships to talented young scientists from around the world who wish to pursue a doctoral degree in #biomedicine!

Learn more and apply now!

General call ➡️ https://bit.ly/3LtzIXi
IRB DRIVE call ➡️ https://bit.ly/4hODx5B

R/Bioconductor for Mass Spectrometry and Proteomics Dates 17-19 November 2025 To foster international participation, this course will be held online

🎓 Upcoming Online Course: R/Bioconductor for Mass Spectrometry & Proteomics

📅 November 17–19, 2025

Join Dr Laurent Gatto for a hands-on course on mass spectrometry–based proteomics analysis using R and Bioconductor.

👉 Register & learn more: www.physalia-courses.org/courses-work...

Job announcement: The image has a solid dark blue background with a clean, minimal layout. In the top left corner, the word “JOBS” appears in all-capital red sans-serif text. Below, large white sans-serif text spans several lines and reads: “Three Independent Group Leaders in Bioengineering Approaches to Human Health m/f/d.” Near the bottom left, smaller white sans-serif text reads: “Apply by November 16, 2025,” followed by “Max Delbrück Center (Berlin-Buch)” in lighter gray. In the bottom right corner is the Max Delbrück Center logo in white and blue.

🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program.

Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.

👉 Apply now: www.mdc-berlin.de/career/jobs/...

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct

Epigenetics Update - A PHF19-YTHDC1 condensate switches EZH2-mediated gene suppression to activation for prostate cancer progression bit.ly/3WldyJd

#Epigenetics #Chromatin #ProstateCancer #Cancer
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High-resolution insights without cell sorting; epigenometech.com

🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool.

👉 www.molgen.mpg.de/5099133/schu...

KATMAP infers splicing factor activity and regulatory targets from knockdown data - Nature Biotechnology A biophysical model uses knockdown or overexpression data to infer splicing factor activity.

KATMAP infers splicing factor activity and regulatory targets from knockdown data - @daspliceisright.bsky.social go.nature.com/47ycrMJ

E15 Groups The Helmholtz Institute for RNA-based Infection Researchopens a call for

🚨 Last chance!
The Helmholtz Institute Würzburg is offering 2️⃣ JUNIOR GROUP LEADER POSITIONS in RNA BIOLOGY, RNA TECHNOLOGY or RNA MEDICINE. 🧬🧫 💻 ⚕️
The deadline is today, so apply now at www.helmholtz-hiri.de/en/e15-groups/

Start der Ausschreibung "Global Minds in DFG-Verbünden": Neue Fördermöglichkeiten für Professuren und Mercator-Fellows aus dem Ausland in Exzellenzclustern & SFB, ermöglicht durch das 1000-Köpfe-plus-Programm des #BMFTR. Hintergründe und Details: https://sohub.io/uuzn

#RNASky

Wow! Max Planck is coming to Würzburg! 🥳

Von links nach rechts: Markus Blume, Patrick Cramer, Markus Söder, Simone Schwanitz und Hubert Aiwanger

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Die Bayerische Staatsregierung und die @maxplanck.de wollen den Wissenschaftsstandort Würzburg stärken. Ein heute unterzeichnetes Memorandum of Understanding legt den Grundstein für den Ausbau der Forschung in der Biomedizin. Auf eine starke Partnerschaft!
📸 Axel Griesch

Great time visiting the groups of Carmo Fonseca, Joel Perez-Perri, and Nuno Morais (@nmoraislab.bsky.social) at Gulbenkian Institute for Molecular Medicine (GIMM) in Lisbon 🇵🇹

Thanks for great discussions on nuclear speckles, RNA-binding proteins, and other exciting topics!

#ScienceVisit #RNA #GIMM

Sequential verification of transcription by Integrator and Restrictor Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restrictor acts over a downstream “restriction zone.” For transcription to proceed, CDK7/9 oppose Integrator, while U1 snRNP counteracts both Integrator and Restrictor.

Online Now: Sequential verification of transcription by Integrator and Restrictor Online now:

Here the version with the correct titles.

Remodeling of RNA-binding proteome and RNA-mediated regulation as a new layer of control of sporulation | mSystems Understanding how bacteria survive extreme conditions is key to tackling challenges in health, food safety, and industry. This study reveals a previously unexplored layer of control in Bacillus subtil...

Thrilled to share my first last-author paper, just out in #mSystems! A work about #RBPs, #RNA and #sporulation in #subtilis.
Special thanks to my brilliant student T. Kaboré who's signing hist first PhD paper and to the whole team @galinier-lab.bsky.social
👉 journals.asm.org/doi/10.1128/...

The emerging roles of long non-coding RNAs in the nervous system - Nature Reviews Neuroscience Long non-coding RNAs are abundant in the brain, where they are proposed to regulate numerous processes. In this Review, Mattick and colleagues describe our current understanding of their mechanisms of...

Nice review on lncRNAs in the brain by John Mattick and colleagues.

doi.org/10.1038/s415...

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views The advent of system-wide proteomic approaches has largely expanded the number of RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming our understanding of biolog...

Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...

Figure 2. Overview of N6-methyladenosine (m6A) decay pathways. m6A acts as a destabilizing mark on mRNA.

"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues

"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."

Read it here:
authors.elsevier.com/sd/article/S...

I am sooo excited. Starting tomorrow the next edition of the fabulous #emboiclip2 course begins. @koenig-lab.bsky.social, @zarnack-group.bsky.social, moi & Elias Bechara will present 3 improvements to the method, a semi-automated workflow for data analysis and an exciting line up of speakers. Ready?

PhDs & Postdocs of @uni-wuerzburg.de struggling to finish a project? Join our Long Night Against Procrastination!

✅ Tips on motivation & writing
✅ Pizza & plenty of coffee
✅ Work through the night with peers from all disciplines

📅 Oct 23, 2025 | 5pm–midnight
📍 Graduate Schools Building