MPI Dortmund

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders The combination of bicyclic monoterpene- and pyrrolidine-alkaloid fragments yields novel pseudo-natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of...

Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders - Published by the Waldmann Group in @angewandtechemie.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

Dancing proteins keep cells moving

Researchers from @raunser-lab.bsky.social have redefined the function & role of key factors in actin filament disassembly. "We uncovered a dance between proteins - a molecular choreography.” Congrats @woutoosterheert.bsky.social et al. @cellpress.bsky.social

www.mpi-dortmund.mpg.de/news/dancing...

"My time at the MPI Dortmund has been amazing! Not only have I made many friends, but I've also gained the required skills that laid the foundation for the next step in my career. "

Congrats to @woutoosterheert.bsky.social on his new group leader position at the the Netherlands Cancer Institute

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.

www.sciencedirect.com/science/arti...

Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

We are happy to announce that we will have two new scientific groups led by Andrija Sente and Katerina Naydenova soon! If you are interested to join their lab as a PhD Student apply at our @imprs-lm.bsky.social

www.imprs-lm.mpg.de/index.php/jo...

Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply NOW for a #fullyfunded #PhDpositions @IMPRS-LM.

Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing - Nature Communications The dysregulation of the inositol-requiring enzyme 1 alpha (IRE1α) has been associated with multiple human diseases, so IRE1α-targeting small molecules present great therapeutic potential. Here, the authors report a series of substituted indoles as IRE1α inhibitors of good potency and selectivity, and show that the inhibitor IA107 allosterically inhibits IRE1α RNase activity via binding to the IRE1α kinase domain but without inhibiting the IRE1α dimerization.

New paper alert! ⏰
Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing

Published by the lab of Peng Wu in @nature.com Communications

www.nature.com/articles/s41...

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

📃 New paper alert!
The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com:
www.nature.com/articles/s41...

Two routes, one goal – How the crown of cell division is manufactured

@vcmentowski.bsky.social & @andrea-musacchio.bsky.social have solved the mystery surrounding the ‘crown’ of #celldivision . They showed how the #kinetochore #corona is constructed and how this guarantees the error-free distribution of #chromosomes

www.mpi-dortmund.mpg.de/news/crown-o...

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...

Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

Pushing calcium against the flow: high-speed pumps in the cell

Pushing calcium against the flow: high-speed pumps in the cell - The first comprehensive transport model of a plasma membrane calcium pump explains its high speed and opens up new avenues for drug development
www.mpi-dortmund.mpg.de/news/pushing...

Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases - Nature Structural insights into ultrafast Ca2+ transport by plasma membrane Ca2+-ATPases are provided, highlighting an essential role for PtdIns(4,5)P2 dynamics.

paper alert🚨
Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases - published by @raunser-lab.bsky.social @maxplanck.de & Fakler lab @uni-freiburg.de in @nature.com
www.nature.com/articles/s41...

MPI group leader appointed to University of Münster

"My time at the MPI has laid a very strong foundation for this next step in my career and I couldn't have done it without the excellent support of the institute."

The MPI congratulates Peter 't Hart on his appointment to the University of Münster!

www.mpi-dortmund.mpg.de/news/thart-m...

Molecular requirements for PLK1 activation by T-loop phosphorylation Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...

www.biorxiv.org/content/10.1...

Are you curious about what PLK1 kinase is up to these days? Have a look at our latest review on @cp-trendscellbio.bsky.social. Arianna Esposito Verza, @andrea-musacchio.bsky.social and I discuss the latest findings on a very important enzyme that is still full of surprises, 35+ years from discovery!

Packing DNA on time for cell division

Packing 🧬DNA on time for cell division
Trans-European research team discovers how a molecular switch controls DNA packing on time for cell division

Read the story ▶️ www.mpi-dortmund.mpg.de/news/packing...

Your PhD journey starts NOW! Join our #webinar on Sept 4 (1-3 PM CEST) to explore #PhD opportunities at Max Planck's #PhDprograms in NRW, Germany! 🇩🇪
Gain insights into groundbreaking research & register here: events.gwdg.de/e/PhDatMaxPl...
#IMPRS #MaxPlanck #Research #Germany #Science

SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...

Condensin II activation by M18BP1 Condensin I and II promote the drastic spatial rearrangement of the human genome upon mitotic entry. While condensin II is known to initiate this proc…

Condensin II activation by M18BP1 - published by @andrea-musacchio.bsky.social Lab & @alessandrovannini.bsky.social @humantechnopole.bsky.social & Rowland Lab @nkinl.bsky.social in molecular @cellpress.bsky.social

congrats to @duccioconti.bsky.social et al.

www.sciencedirect.com/science/arti...

Arp2/3-complex regulation – Novel insights and open questions Arp2/3 complex is a central actin filament generator driving numerous motile processes in cells. It was originally isolated from Acanthamoeba approx. …

Arp2/3-complex regulation – Novel insights and open questions - published by Peter Bieling, Micaela Boiero Sanders and Theresia Stradal in Curr Opin Cell Biol.

www.sciencedirect.com/science/arti...

I have an open postdoc position in my group at @mpi-dortmund.bsky.social @maxplanck.de!

If you are passionate about structural biology and/or membrane proteins, apply today!

The position is initially funded for two years, starting from this October. Deadline for application is on July 15th.

The MtL Lecture Series continues with talks by Marcus Müller from @uni-goettingen.de‬, Andrea Musacchio from @mpi-dortmund.bsky.social & @unidue.bsky.social‬, and David Zwicker from the Max Planck Institute for Dynamics and Self-Organization.
Register now on our website!

Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex - Nature Communications The spindle assembly checkpoint protects cells from chromosome missegregation. Here, the authors use sophisticated biochemical reconstitutions to address how kinetochores, the microtubule-binding stru...

🚨Paper alert🚨
Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex - published by the @andrea-musacchio.bsky.social Group in @natcomms.nature.com
www.nature.com/articles/s41...

With great sadness and deep regret, we have to inform you that our department director and highly esteemed colleague Philippe Bastiaens @maxplanck.de passed away suddenly and unexpectedly on 15th of May.

Promising Parkinson's drug decoded

There are currently high hopes for the development of novel Parkinson's drugs. Malte Gersch & his team have now deciphered the mode of action of these drugs. The findings can help to develop innovative therapeutics for Prakinson's disease & other disorders.
www.mpi-dortmund.mpg.de/news/promisi...

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature Structural & Molecular Biology Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a framework for specific deubiquitinase inhibition.

New Parkinson’s disease paper:
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by Malte Gersch group in Nature Struct. & Mol. Biol.
www.nature.com/articles/s41...

Congrats to our @crc1430.bsky.social member @vcmentowski.bsky.social on defending her PhD in the @andrea-musacchio.bsky.social Lab! 🎓👏 A remarkable achievement that showcases her dedication and hard work. We’re excited for her future successes! 🎉 #PhDDefense #ResearchExcellence #AcademicAchievement"

An Indole Dearomatization Strategy for the Synthesis of Pseudo‐Natural Products The indole moiety is a privileged fragment that frequently populates existing bioactive compound collections. We describe the development of an indole-dearomatization sequence and its application for....

New Publication by the @waldido.bsky.social Group:
An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products - Published in ChemBioChem

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Congrats for a fantastic defense and your even more fantastic achievements @vcmentowski.bsky.social

We congratulate Max Haase, #Postdoc in the @andrea-musacchio.bsky.social group , on receiving the highly-coveted Marie Sklodowska-Curie (MSCA) Postdoctoral Fellowship funded by the @ec.europa.eu Commission