Despite the harms of traditional GET, movement within an individual's energy envelope and pacing around small amounts of tolerable movement may sometimes be helpful. See this great video by @putrinolab.bsky.social www.youtube.com/watch?v=pfox...
20.02.2026 19:24 — 👍 0 🔁 1 💬 1 📌 0
The EPPL is recruiting for a remote (app-based) pilot study examining whether light, fully self-paced, swimming may be a tolerable form of movement for people with ME/CFS and related conditions, due to the distinct physiological effects of water immersion. #ME/CFS #ME #POTS #LongCovid
20.02.2026 19:24 — 👍 1 🔁 3 💬 1 📌 0
Yes, it’s tricky. There’s a mechanistic rationale as to how it could work, as it helps normalize preload similarly to drugs (such as in this study: www.sciencedirect.com/science/arti...). That said, over-exertion will always cause PEM, so staying within that energy envelope will be the tricky part
24.02.2026 16:10 — 👍 1 🔁 0 💬 0 📌 0Contact information can be found here: www.exercisephysiologyandperformancelab.com/get-involved
20.02.2026 19:24 — 👍 0 🔁 0 💬 0 📌 0Note: this is not an exercise training or rehabilitation study, and participation is only intended for individuals who can tolerate gentle activity and be in public spaces without triggering PEM. Participants should also be comfortable with swimming, although flotational devices are welcomed.
20.02.2026 19:24 — 👍 0 🔁 0 💬 1 📌 0A light cycling session is available as an optional comparator for those with mild conditions who feel comfortable doing so. If you feel you may be a suitable candidate, please reach out for more details.
20.02.2026 19:24 — 👍 0 🔁 0 💬 1 📌 0Recruitment: We are recruiting adults with mild-to-moderate ME/CFS and related conditions for this study examining short-term symptom and autonomic responses to gentle swimming. Participants will choose their own intensity and duration and may stop at any time. This pilot study is entirely remote.
20.02.2026 19:24 — 👍 0 🔁 0 💬 1 📌 0Swimming may be the ideal form of movement for those that can tolerate it, as the horizontal posture and hydrostatic pressure of water supports passive venous return and reduces orthostatic stress, while cool water exposure may influence autonomic and inflammatory responses.
20.02.2026 19:24 — 👍 0 🔁 0 💬 2 📌 0
Despite the harms of traditional GET, movement within an individual's energy envelope and pacing around small amounts of tolerable movement may sometimes be helpful. See this great video by @putrinolab.bsky.social www.youtube.com/watch?v=pfox...
20.02.2026 19:24 — 👍 0 🔁 1 💬 1 📌 0This treatment caused harm, as exercise exacerbated symptoms and led to a worsening of disease severity. Today, it is recommended that patients pace their energy carefully, and stay within their energy envelopes in order to prevent post-exertional malaise / symptom exacerbation.
20.02.2026 19:24 — 👍 0 🔁 0 💬 1 📌 0Background: PwME/CFS experience profound exercise intolerance and post-exertional malaise. Historically, ME/CFS was seen as a psychosomatic disorder, and physiological symptoms were thought to be due to deconditioning. Treatment was Graded Exercise Therapy and Cognitive Behavioural Therapy.
20.02.2026 19:24 — 👍 0 🔁 0 💬 1 📌 0
The EPPL is recruiting for a remote (app-based) pilot study examining whether light, fully self-paced, swimming may be a tolerable form of movement for people with ME/CFS and related conditions, due to the distinct physiological effects of water immersion. #ME/CFS #ME #POTS #LongCovid
20.02.2026 19:24 — 👍 1 🔁 3 💬 1 📌 0
Crucial paper published Friday that deserves much more attention in the #LongCOVID world: www.nature.com/articles/s41...
TLDR: 13/15 immunocompromised patients who had chronic COVID infections (>200 days) cleared the virus in under 2 weeks when given combo antivirals/monoclonals
1/
Most flowmeters don’t do well with very high ventilations either - so that probably compounded any calibration errors
31.01.2026 23:50 — 👍 2 🔁 0 💬 1 📌 0Occam’s razor says this is a cart calibration / setup issue!
31.01.2026 23:45 — 👍 3 🔁 0 💬 1 📌 06/ Invasive cardiopulmonary exercise testing (iCPET) in subsets identified preload failure in 96% of Long Covid and 92% of ME patients tested.
27.01.2026 17:46 — 👍 4 🔁 1 💬 1 📌 0
An informational graphic titled "SHARED AUTONOMIC & NEUROVASCULAR DYSFUNCTION" under the categories "LATEST RESEARCH" and "ME/LONG COVID." The center features a photo of two researchers in a laboratory wearing white coats, hairnets, and blue gloves, carefully examining a blue liquid in a test tube. Below the image, text reads: "This study shows that Long COVID and ME/CFS share a common autonomic and neurovascular profile, including reduced cerebral blood flow, autonomic dysfunction, and small fiber neuropathy, supporting a shared underlying pathophysiology rather than distinct diseases." The bottom right attributes the source to "Novak et al, 2026, Plos One," and the bottom center features the "LONG COVID ADVOCACY" logo.
1/ A new study from Brigham and Women’s Faulkner Hospital, led by prominent researchers Peter Novak, David Systrom, and colleagues, compared 143 Long Covid, 170 ME/CFS, 73 healthy controls, and 290 hEDS patients to map shared autonomic and neurovascular dysfunction. 🧵
27.01.2026 17:46 — 👍 32 🔁 15 💬 1 📌 2
new 🧵
Maybe myocardial fibrosis is an arrhythmogenic substrate which is activated by intense exercise in certain veteran athletes
Timing and Relationship of Ventricular Arrhythmia with Exercise Patterns in Veteran Male Endurance Athletes url: academic.oup.com/eurjpc/artic...
2 million! The scale of people that this review reached is incredible
I can only imagine what the next 3 years of researching and publishing on Long COVID has in store for us 🎢
Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome — Martini Sasso et al. "We identified a significant reduction in TRPM3 ion channel function in NK cells isolated from ME/CFS patients, both in response to stimulation with the agonist PregS (p < 0.0001) and in suppression of activation using ononetin (p < 0.0001)."
Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
www.frontiersin.org/journals/med...
Screenshot from latest Science for ME weekly update
#MEcfs #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome
From regenerative medicine to reproductive technologies and everything in between, Nature Medicine gives its selection of critical developments that moved medicine forward in 2025. #medsky 🧪
12.01.2026 14:14 — 👍 13 🔁 8 💬 0 📌 0
This is figure 3, which shows the effect of the zoster vaccine on new diagnoses of dementia.
The shingles vaccine reduced the probability of new #dementia diagnoses by around one-fifth over seven years, according to a large-scale study of a population in Wales, UK, reported in Nature in April. go.nature.com/4460AE4 🧪
30.12.2025 14:50 — 👍 40 🔁 16 💬 0 📌 1
Certainly hopeful news. We lost my father-in-law to dementia. It’s good to see they’re closing in on a cure.
case.edu/news/new-stu...
Together with Andy Jones and Lars Nybo, here is our brief view about:
- How Physiological Resilience and Durability should be distinguished
- How they link the abundant literature on fatigue development with endurance performance models.
journals.physiology.org/doi/full/10....
Doctor in white coat drawing a red heartbeat line ending in a heart symbol with a marker.
How fast blood pressure pulses move through your arteries shows more than stiffness. It reflects artery health and whole body factors that shape your heart risks. More in APS Publications AJP-Heart: https://ow.ly/zGNC50XHCyS #ArticlesInPresS 🧪
📷: iStock
New report in Journal of Applied Physiology studies whether different levels of #carb ingestion by elite male #marathon #runners confer a metabolic advantage by better maintaining whole body rates of carb oxidation & improving running economy 🏃♂️➡️ https://ow.ly/wg9j50XJSgA
15.12.2025 18:36 — 👍 3 🔁 2 💬 0 📌 0🤦
11.12.2025 22:06 — 👍 11 🔁 4 💬 0 📌 0New link: cdnsciencepub.com/doi/full/10....
28.11.2025 15:49 — 👍 1 🔁 0 💬 0 📌 0This suggests that athletes may be well adapted to handle high glucose flux, but when the training load is reduced there could be a window of vulnerability. Exciting area for further research! @apnmjournal.bsky.social @hplburr.bsky.social
27.11.2025 15:23 — 👍 2 🔁 0 💬 1 📌 0
