Lee Grimes Lab

Postdoc Kyle Ferchen figured out how to integrate CITE-seq, TEA-seq and InfinityFlow to link cell surface markers, gene expression, and chromatin accessibility to underlying gene regulatory networks (GRNs). Clusters, gene expression and GRN edges are searchable here: altanalyze.org/MarrowAtlas/...

A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice Nature Immunology - Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene...

New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.

With potential NIH budget cuts and funding freezes putting vital work at risk, the ASH Bridge Grant is helping researchers, and their discoveries stay on track to improve patient care. #Fight4Hematology

This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! https://bit.ly/3HJ51Ma

#HemeSky #MedSKy #ASHAwards

The focus here is on any abstract section with the word basic in it. The quality of the submissions will be paramount.

ASH Seeks Fundamental Discovery Science Abstracts for #ASH25
IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25.
Its an experiment!
Submit your cool basic science before August 5, 2025, at 11:59 p.m.

ASH is committing more than $12 million to address research funding challenges and support the next generation of hematologists.

Learn more: ow.ly/sK3050W735W

ASH has made an unprecedented investment of more than $12 million. Including ~$9 million increase in award funding. Total awards commitment of more than $20 million over the next 12 months....providing support for an additional 600+ awardees at all career stages. @ash.hematology.org

ASH Bridge Award direct cost floor was already raised to $500K/yr. Now the number of applications funded is dramatically increasing, with a rapid turn around...and a brand new additional cycle this year. @ash.hematology.org

Are you concerned about how to get your trainees to ASH2025 in Orlando? Massive increase in trainee travel awards for those giving poster or oral presentations. Submit those abstracts and find out! @ash.hematology.org

Coming soon.....news about increasing fundamental basic science representation at ASH...we are running an experiment!....hope you will participate in ASH2025.
@ash.hematology.org

Feeling like the worst “Rainy Day” has hit your hematology lab?
ASH is deploying some significant umbrellas.
More details soon!
Watch @ash.hematology.org

If you are invited to review abstracts for ASH2026 in a basic science category, please know that I reviewed these sections and pushed for you to do this work. PLEASE HELP ME OUT. We want to increase the quality and representation of basic science at ASH.

Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias Broad dysregulated splicing in AML partially phenocopies splicing factor mutations, is prognostic, and can be pharmacologically reversed.

New in STM, check out our integrative bulk & single-cell long-read analysis to discover and test new therapies in leukemia. We developed OncoSplice, to define new splicing defined subtypes and predict regulators. PRMT5 inhibition partially rescued mis-splicing & inhibited leukemic growth. More soon!

Congratulations to both Bing and the Genome Center

Congratulations

The first NIH posting to the Federal Register since the inauguration appeared today. It lists several study section meetings. Great news! www.federalregister.gov/documents/20...

Trump Tracker: Firings, lawsuits, and U.S. science in chaos Follow President Donald Trump’s impact on U.S. research and science globally

"A freeze on meetings of expert panels that peer review grant proposals at the NIH is kicking in this week ... Trump barred NIH from posting new Federal Register notices, which means any study section not advertised before then cannot take place." #medsky 🧪

www.science.org/content/arti...

Here is the FedEx package Linda Wolfe sent me in 2010 which included all the financials for MYELOID when it was the “Annapolis meeting”
Oh my! It’s a lot more expensive these days!

The 15th International Workshop on Molecular Aspects of Myeloid Stem Cell Development, will be held at the Jarson-Kaplan Theater of the Aronoff Center for the Arts in Cincinnati, Ohio on May 18-21, 2026. Please hold these dates on your calendar.

ohio

Aura points

Rebecca Black (ask your kids) came to Seacrest Studio and Grimes Lab peeps Connor and Sierra got to say hello!

Holiday (science) Spirit here at CCHMC in the Hildeman Lab

#ASH peeps at the Bollywood themed Presidential reception. #ASH24 #HemeSky

Is the survival disparity observed in Black AML patients linked to underlying differences in disease biology? Come learn about PHIP, a previously overlooked oncogene found in Black patients, at my talk tomorrow (12/7) at 4:30🩸 #ASH24 #AML #healthequity @leegrimeslab.bsky.social

Postdocs with talks get cake!! #ASH24 #HemeSky
OK. They might get cake anyway, but they do have talks in 618 Saturday and Sunday!

#ASH24 #HemeSky
Celebrating the excellent leadership of Mohan Narla as this year’s President of ASH.

Welcome to #ASH2024 as the morning fig burns off and the meetings begin! #HemeSky

I will be there!