Neil Rajan

Image Challenge What is the diagnosis? A photo the patient’s chin

A 47-year-old woman presented to the dermatology clinic with a 1-year history of a crawling sensation on her chin that caused her to scratch the area. The right corneal reflex was decreased, and pinprick and temperature sensation around the mouth, lip, and chin on the right side was reduced. 1/2

Women in Science 2026 by ESDR

Did you know that in research, women are still underrepresented even though this may affect treatment outcomes?

Explore the campaign to learn more: esdr.org/women-in-sci...

#womeninscience #dermatology #dermresearch
@derm-scientist.bsky.social

Women in Science 2026 by ESDR

For this year’s International Day of Women and Girls in Science, we’re highlighting why inclusive data is essential for robust science.

Better data means better science for everyone.

Explore the campaign: esdr.org/women-in-sci...
@derm-scientist.bsky.social

Women in Science 2026 by ESDR

By making underrepresentation visually, scientifically & socially visible, we aim to contribute to a future where medical research truly reflects the diversity of the patients it serves.

esdr.org/women-in-sci...
@derm-scientist.bsky.social

Women in Science 2026 by ESDR

For this year’s “International Day of Women and Girls in Science” day, we’re highlighting why inclusive data is essential for robust science.

Explore the campaign: esdr.org/women-in-sci...
#womeninscience

@derm-scientist.bsky.social @dr-cganier.bsky.social

Thanks @ishier.bsky.social shout out to @joe inns for all his hardwork! Thanks to great collaboration with you, @mtrost.bsky.social and @mads gyrd-hansen.

Nice preprint from @derm-scientist.bsky.social! Ubiquitin system is key for tissue architecture in CYLD cutaneous syndrome (CCS) skin tumours.
"Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion."
www.biorxiv.org/content/10.6...

This is figure 1, which shows longitudinal follow-up.

A paper in Nature reports the details of a 60-year-old male individual from Germany who achieved sustained HIV remission after a stem cell transplant, the seventh-known case reported to date. go.nature.com/4rNjedx #medsky 🧪

Absolutely! Let's keep building! @esdrorg.bsky.social ❤️❤️

Close-up of two hands with symmetrical, concentric ring-shaped, vesiculobullous lesions on the dorsal surface of the thenar eminence. Text: "Figure 1. Concentric Ring-Shaped Vesiculobullous Lesions on the Dorsum of the Thenar Eminence, Presenting Bilaterally and Symmetrically."

This case report describes a child with lesions that initially appeared as vesicles and progressively spread in a centrifugal pattern, forming concentric, spiraled rings.

ja.ma/48dpF1s

Coevolution of cooperative lifestyles and reduced cancer prevalence in mammals While cooperative mammals evolve reducing cancer prevalence, oncogenes can be maintained by selection in competitive species.

Why do whales and elephants have much lower rates of cancer than expected?
"Species with a lower cancer prevalence and mortality
risk are those with a higher presence of cooperative and caring habits, while the opposite is found....:"
www.science.org/doi/10.1126/...

Sounding Board "Nearly 30 years after the sequencing of the human genome, bespoke therapies are close to reality. The FDA will work as a partner and guide in ushering these therapies to market, and our regulatory strategies will evolve to match the pace of scientific advances." "FDA’s New Plausible Mechanism Pathway Vinay" by Prasad, M.D., M.P.H., and Martin A. Makary, M.D., M.P.H.

Personalized therapies hold tremendous promise but challenge traditional models of drug and biologic development. The @fda.gov outlines a path to market entry for products where a randomized trial is not feasible. Learn more: nej.md/4nUQdcl

Carcinoma erysipeloides

Image Challenge What is the diagnosis? Left: Photo of the rash on the chest Right: Histopathology of a skin-biopsy sample from the left chest-wall scar

A 75-year-old woman with a history of infiltrating ductal carcinoma of the breast (previously treated with bilateral radical mastectomy and ongoing adjuvant hormonal therapy) presented to the dermatology clinic with a 1-year history of rash on the chest. 1/2

#MedSky #DermSky

Previous multiple sclerosis, now the potential role of Epstein Barr virus for driving lupus (SLE)
science.org/doi/10.1126/...

With support from the NIHR Newcastle BRC, researchers Professor Neil Rajan @derm-scientist.bsky.social and Dr Mark Eisner from the Skin Disease, Oral Disease and Immunogenomics Theme attended the recent Ichthyosis Support Group (ISG) Family Day.
🔗 newcastlebrc.nihr.ac.uk/our-research...

Selena Gomez has shared her experiences living with #lupus since 2015 - writes Foundation-funded researcher @bcellsrosser.bsky.social for @uk.theconversation.com.

To learn more, you can meet Dr Lizzy Rosser at our New Scientist Live stand (C20) on 18-19 October! shorturl.at/BusFG

Spatial architecture of development and disease - Nature Reviews Genetics Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within and across organs. The authors review spatially resolved molecular changes across diseases and discuss the potential of spatial multi-omics for clinical applications, including the recent impact of artificial intelligence.

Review | Spatial architecture of development and disease www.nature.com/articles/s41...

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

We're delighted to see immunologists once again recognised by the #NobelPrize! 🏆

Warm congratulations to the winners - their contributions have been vital in shaping our understanding of the immune system.

More here: www.immunology.org/news/british...

Liverpool skyline%2C plenary session ' Immunology in the balance'

📅 Wed 3 Dec | Immunology in the balance with Prof. Lydia Lynch

How does the immune system walk the line between protection & pathology? Join this session on the regulation of innate & adaptive immunity in infection, cancer, and inflammatory disease.

#Immunology #BSI25

Rocking it!

Dermatology joins GeNotes as 12th specialty - Genomics Education Programme New dermatology collection covers a wide range of clinical scenarios, underpinned by extended opportunities for learning Dermatology professionals now have access to a fantastic new set of useful reso...

www.genomicseducation.hee.nhs.uk/news/dermato...

Calling all #dermatologists! We've just launched our new #GeNotes collection of resources to support you in accessing #GenomicTesting for your patients. Developed by Dr fellow dermatology experts, this is one not to miss!

Great work Christoph 👏🏾

IL-18 in atopic dermatitis—a multifaceted driver of skin inflammation Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by pruritus, barrier dysfunction, and immune cell infiltration. Despite significant progress in our understanding of ...

🚀 Excited to share our new Review in @jacionline.bsky.social !
We summarize the current evidence on IL-18 in atopic dermatitis.

📊 Links to barrier dysfunction & disease severity
💡 Potential biomarker & therapeutic target

Read here 👉 www.jacionline.org/article/S009...

#IL18 #atopicdermatitis

We’re thrilled to introduce our four official Social Media Ambassadors for the 54th Annual ESDR Meeting!

esdrmeeting.org/some2025/

@dr-hanat.bsky.social @dr-cganier.bsky.social @derm-scientist.bsky.social @drarmpit.bsky.social

Videos show pronuclear transfer, which was performed in a series of women with pathogenic mtDNA variants to reduce the transmission of these variants to their children. Read the full study about this method: nej.md/455eer6

#MedSky #Genetics

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

The potential for 2 cancer drugs in combination to impact Alzheimer's disease as an outgrowth or single-cell RNA -seq, review of electronic health records from 1.4 million patients, and whittling down 1,300 potential repurposed drugs to 2.
www.cell.com/cell/fulltex...

The babies born with DNA from three parents – podcast Doctors in the UK have announced the birth of eight healthy babies after performing a groundbreaking procedure that creates IVF embryos with DNA from three people. Ian Sample tells Madeleine Finlay ab...

Amazing podcast on the mitochondrial donation babies. Great work by wonderful colleagues@mitonewcastle.bsky.social at @newcastleuni.bsky.social and the @lilyfoundation.bsky.social

www.theguardian.com/science/audi...

In vivo prime editing rescues alternating hemiplegia of childhood in mice Prime editing and base editing in mouse models and human cells effectively correct mutations in a gene that causes a childhood neurodevelopmental disorder called alternating hemiplegia of childhood. I...

One-shot prime genome editing ("CRISPR 3.0") of the brain in vivo corrected AHC, a rare genetic disorder, in the mouse model. Another big step forward in the genome editing field.
www.cell.com/cell/fulltex...