Neil Rajan

Videos show pronuclear transfer, which was performed in a series of women with pathogenic mtDNA variants to reduce the transmission of these variants to their children. Read the full study about this method: nej.md/455eer6

#MedSky #Genetics

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

The potential for 2 cancer drugs in combination to impact Alzheimer's disease as an outgrowth or single-cell RNA -seq, review of electronic health records from 1.4 million patients, and whittling down 1,300 potential repurposed drugs to 2.
www.cell.com/cell/fulltex...

The babies born with DNA from three parents – podcast Doctors in the UK have announced the birth of eight healthy babies after performing a groundbreaking procedure that creates IVF embryos with DNA from three people. Ian Sample tells Madeleine Finlay ab...

Amazing podcast on the mitochondrial donation babies. Great work by wonderful colleagues@mitonewcastle.bsky.social at @newcastleuni.bsky.social and the @lilyfoundation.bsky.social

www.theguardian.com/science/audi...

In vivo prime editing rescues alternating hemiplegia of childhood in mice Prime editing and base editing in mouse models and human cells effectively correct mutations in a gene that causes a childhood neurodevelopmental disorder called alternating hemiplegia of childhood. I...

One-shot prime genome editing ("CRISPR 3.0") of the brain in vivo corrected AHC, a rare genetic disorder, in the mouse model. Another big step forward in the genome editing field.
www.cell.com/cell/fulltex...

🍷 Save the Date! 🍷

Join us for an evening of wine tasting at the historic Trinity House in support of North East skin research.

🗓️ Friday 14th November 2025
📍 Trinity House, Newcastle
🎟️ All proceeds go directly to the North East Skin Research Fund

☀️ A fun Summer evening at The Magic Hat Cafe last night showcasing some of the fantastic skin research we have across the North East

✨ Thank you to everyone who attended and for supporting our North East Skin Research Fund

Sex differences in skin-cancer risk are linked to oestrogen levels Premenopausal women are more likely than men to develop certain cancers. Pathways activated by the sex hormone responsible could be targeted in cancer therapies.

Premenopausal women are more likely than men to develop certain cancers. Pathways activated by the sex hormone responsible could be targeted in cancer therapies

https://go.nature.com/445tJ0u

Incredible opening keynote by Charlie Swanton - spanning tumour initiation, aging, environmental exposure and much more 👏👏

#EACR2025
@charlesswanton.bsky.social
@crick.ac.uk
@helloeacr.bsky.social

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science

https://go.nature.com/4kIRR01

Welcome @northeastskin.bsky.social 😄

👋 Hello Bluesky! 🦋 We are the North East Skin Research Fund - bringing you the latest updates on skin research led by dermatologists and academics here in the North East of England! 🧴🧪

📸 Featuring our new logo

#NESRF #northeastskin #northeast #northeastengland #skinresearch #dermatology

Cutaneous Fibrofolliculomas and Trichodiscomas in... : Dermatologic Surgery developing recommendations for surgical treatment. METHODS A literature search was conducted to review cases of BHD associated fibrofolliculomas and trichodiscomas and the role of cryosurgery, cure...

“Cutaneous fibrofolliculomas and trichodiscomas in Birt-Hogg-Dubé syndrome: a review of therapeutic strategies” is now out in Dermatological Surgery! 🎉 journals.lww.com/dermatologic...

A real testament to the BHD patient advocates and @derm-scientist.bsky.social who have championed this work!

Great work William 👏🏾

Review Article: Cell Therapy and the #Skin: Great Potential but in Need of Optimization.
Lee et al
doi.org/10.1016/j.ji...
#DermatologyJournal #dermatology #dermsky #dermatologists #dermresearch #dermscience #dermatologyresearch

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F

#ASGCT2025 #MedSky @asgct.bsky.social

Become a Social Media Ambassador for the 54th Annual @esdrorg.bsky.social ESDR Meeting! is a fantastic opportunity to contribute to the success of the meeting while building your professional network and showcasing your creativity. Apply Now! esdr.org/y-esdr/socia...

We are delighted to introduce the recipients of the 2025 ISID Collegiality Awards.
This year’s awardees Longlong Luo and Irene García Jiménez will be formally honored during the award ceremony at the SID 2025 Meeting in San Diego.

Celebrating 20 Years of the International Pachyonychia Congenita Consortium.
Read Coulombe et al's News & Perspective Commentary in the April issue.
doi.org/10.1016/j.ji...
#DermatologyJournal #dermatology #dermsky #dermatologists #dermresearch #dermscience #dermatologyresearch

The amazing Prof Chris Stewart @stewartlab.bsky.social gives his inaugural lecture👏🏾👏🏾👏🏾

Now that's a cool collab!

Can I interest you in some sunscreen? It's Australian! Our latest video in our partnership with @drglaucomflecken summarizes the final, 10-year outcomes of the CheckMate 067 trial, which investigated... TikTok video by NEJM

He’s back! The latest video in our partnership with @glaucomflecken.bsky.social summarizes the final, 10-year outcomes of the CheckMate 067 trial investigating nivolumab plus ipilimumab in advanced melanoma:

#medsky #cardiosky

San Diego skyline illustration with sand, skyscrapers, a palm tree and jet flying across the sky, with SID 2025 Annual Meeting: San Diego May 7 - 10, 2025 written.

We're just over a month out from our Annual Meeting. This year, thousands of #dermatology researchers, industry professionals and trainees are gathering in San Diego to learn + connect around breakthrough #skinscience. There's still time to register! Learn more at sidannualmeeting.org.

CYLD Cutaneous Syndrome CYLD cutaneous syndrome (CCS) typically manifests in the second or third decade with the appearance of multiple skin tumors including cylindromas, spiradenomas, trichoepitheliomas, and rarely, membran...

CYLD cutaneous syndrome is a rare genodermatosis caused by pathogenic variants in CYLD which results in the development of cylindromas, spiradenomas, and tricoepitheliomas. www.ncbi.nlm.nih.gov/books/NBK555...

Metastatic malignant cylindroma arising on a background of digenic inheritance of BRCA2 and CYLD pathogenic variants targeted with PARP inhibition Management of malignant cylindroma, particularly in the case of metastasis, poses a difficult challenge for clinicians and is limited by a lack of randomiz

Credit to supervisors @derm-scientist.bsky.social and @serenanikzainal.bsky.social and co-authors Dr. Koh, Ms. Holt, Dr. Husain, Dr. Namini, Dr. Mathew, Dr. Memari, and Dr. Davies for their hard work on this project 👏🏼

academic.oup.com/ced/advance-...

Great work everyone! Super collaboration 👏🏾👏🏾👏🏾 thanks for the support from @nihrnewcastlebrc.bsky.social for the Newcastle work.

Join us for an exclusive ISID Kitchen episode!
28 May, 1.30pm CET
Free Registration lnkd.in/eTNaJajg

We’re bringing together two leading experts, Rei Watanabe and Elaine Fuchs, to discuss the latest insights on #aging. Don't miss this opportunity to learn!

#ESDRKitchen #Dermatology #SkinScience

Great to have you contribute new ideas as the young ESDR board representative @dr-cganier.bsky.social !

Just returned from Antwerp after an inspiring board meeting! The ESDR stands out as one of the rare research societies that values the voices of young scientists/clinicians, shaping the future of skin research. Grateful to be part of a community dedicated to advancing knowledge & improving health!

Pleased to be in the beautiful city of Antwerp for our board meeting ! Together, we are shaping the future of our society and actively preparing for our annual meeting which will take place here on September 10-13 !
We hope lots of you will come ! Many surprises ahead 🥳

Congrats 👏🏾 👏🏾 👏🏾