Ben Heineike

So with the ease that one can port these impressive projects do we lose some of the lab-based development of particular packages? That would be sad as a user. I would prefer for the developers of an R-based tool to manage the python version.

Congrats Max and thanks for the clear summary - looking forward to reading the full paper!

Non-antifungal medications administered during fungal infections drive drug tolerance and resistance in Candida albicans - PubMed <span><b>Introduction.</b> Fungal infections are increasingly concerning, particularly in immunocompromised patients. These patients often suffer from comorbidities and receive multiple, non-antifunga...

Nice new paper by Mariella Obermaier in the Ralser Lab to understand interactions between common drugs co-administered with antifungals and antifungals on C. albicans pubmed.ncbi.nlm.nih.gov/40720257/

Nice work by @maxhaase.bsky.social about the strange history of yeast centromeres - got to see him present it at #yeast2025

Ancient co-option of LTR retrotransposons as yeast centromeres The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...

It’s out! The evolutionary origins of yeast point centromeres uncovered!

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.biorxiv.org/content/10.1...

Thanks Jacob for your help with this project- was great working with you!

NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com

Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!

www.nature.com/articles/s41...

#alphafold #evolution #genomics

The role of metabolism in shaping enzyme structures over 400 million years - Nature By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...

A paper I have been working on with Oliver Lemke in the Ralser lab has just come out: www.nature.com/articles/s41...

We used predicted structures to gain insight into the evolution of metabolic proteins in yeast.

A bit more in this linked-in post (www.linkedin.com/posts/benjam...).

how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)

Wow - amazing mito video!