Christine Rabinak, PhD, MBA

We’re testing whether low-dose THC given before key Prolonged Exposure sessions can boost fear extinction, engage vmPFC–hippocampal circuits, and improve PTSD outcomes in a randomized, double-blind trial.

doi.org/10.1016/j.cc...

#PTSD #THC #ExposureTherapy #ClinicalTrials

Proteomic and Functional Analysis on Endothelial Cell Heterogeneity Identifies Key Regulators in Hyperglycemia-Induced Dysfunction. | American Journal of Physiology-Cell Physiology | American Physiological Society Endothelial cells (ECs) play a critical role in managing vascular homeostasis and neovascularization. EC functions vary significantly depending on their anatomic locations, especially for ECs forming macrovascular versus microvascular vessels. ECs possess heterogeneous signaling pathways, energy metabolism, and cellular behaviors that enable them to handle both physiological and hyperglycemic conditions. These variations can impact the efficacy of pharmacotherapy and influence the likelihood of unexpected side effects. In this study, we compared human aortic ECs (HAECs) and human dermal microvascular ECs (HDMVECs) to observe the functional and proteomic differences potentially contributing to EC heterogeneity. Compared to HAECs, HDMVECs exhibited faster proliferation, but lower migration and permeability. Under high glucose, migration was worsened for both cell types, whereas proliferation was unaffected, and permeability increased for HDMVECs. Using proteomic analysis, we identified 126 proteins whose abundance was significantly different between HAECs and HDMVECs. DAVID analysis revealed their biological processes, cellular compartments, molecular functions, and pathways. under high glucose, WARS1 increased while SOD2 decreased. Reversing WARS1 or SOD2 expression levels improved HDMVEC migration and permeability functions. The combined treatment of WARS1 knockdown and SOD2 overexpression fully restored EC migration and reduced permeability to levels comparable to those of their counterparts under normal glucose conditions. Furthermore, in the cutaneous wound in type 2 diabetic mice, the combination therapy of Wars1 knockdown and SOD2 overexpression accelerated the wound closure and augmented wound angiogenesis. Our studies provide novel molecular insights into EC heterogeneity and identified WARS1 and SOD2 as potential targets for dermal angiogenesis during tissue repair.

Wayne State EACPHS shows microvascular ECs are more vulnerable to high-glucose stress.
🔗 doi.org/10.1152/ajpc...

#Diabetes #VascularBiology #Proteomics

Assessing Pharmacists’ Use and Perception of AI Chatbots in Pharmacy Practice: Cross-Sectional Survey Study Background: The use of artificial intelligence (AI)–based large language model chatbots such as ChatGPT has become increasingly popular in many disciplines. However, concerns exist regarding ethics, l...

Wayne State EACPHS and colleagues surveyed pharmacists on AI chatbot use.
Only 30% have used AI tools like ChatGPT, but 51.5% plan to begin.
Top uses: summarization, LOR writing & disease info — not patient care decisions.
🔗 doi.org/10.2196/71767
#Pharmacy #AIinHealthcare #DigitalHealth

Wayne State EACPHS highlight how age-related physiologic changes, polypharmacy, and financial barriers impact pulmonary care in older adults.
Proper device selection + inhaler technique + Medicare navigation = better outcomes.
🔗 doi.org/10.1016/j.cg...

#Geriatrics #PulmonaryCare #PharmacyResearch

Whole-genome analysis of extensively drug-resistant Enterobacter hormaechei isolated from two hospitalized patients in the United States: A case series of a rare but rising threat AbstractBackground. New Delhi metallo-beta-lactamases (NDM) confer extensive antibiotic resistance, complicating treatment and leading to poor outcomes. In

Wayne State EACPHS report two NDM-5–producing, extensively drug-resistant Enterobacter hormaechei isolates in Southeast Michigan--highlighting a rare but rising threat and the value of genomic surveillance.

🔗 doi.org/10.1093/jaca...

#AMR #CRE #NDM #PharmacyResearch

Closing the Gap: Evaluating the Safety and Effectiveness of Diabetic Ketoacidosis Nomograms - Amina Ammar, Hassan Fardoun, Elizabeth Hart, Erin Cagadas, Brandon Tatar, Tsz Hin Ng, Kristin M. Janzen, J... Background: Diabetic ketoacidosis (DKA) is a severe complication of diabetes mellitus requiring insulin. However, there is no consensus on insulin infusion titr...

New publication in Annals of Pharmacotherapy co-authored by Wayne State EACPHS evaluates 3 DKA insulin titration nomograms across 350 patients. Hypoglycemia rates differed significantly—36.2% vs 23.9% vs 6.8%—highlighting the need for evidence-based standardization.
🔗 doi.org/10.1177/1060...

Optimizing phage-antibiotic combinations: impact of administration order against daptomycin non-susceptible (DNS) MRSA clinical isolates | Antimicrobial Agents and Chemotherapy Patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) infections, which are associated with high mortality rates, often require prolonged hospitalizations, intensive care service...

Wayne State EACPHS show that adding phages to daptomycin/ceftaroline enhances killing of DNS-MRSA, with simultaneous and phage-first regimens often outperforming antibiotic-first—but with important strain-specific differences.
🔗 doi.org/10.1128/aac....

#AMR #PhageTherapy #MRSA

New research from Wayne State EACPHS in The American Journal of the Medical Sciences!
Real-world evaluation of Evusheld showed low COVID-19 infection rates and zero hospitalizations or deaths in immunocompromised patients 6 months post-administration.

🔗 doi.org/10.1016/j.am...

New publication led by Wayne State EACPHS shows that while IPE learning gains occur across groups, students rate smaller teams more favorably.

🔗 doi.org/10.1016/j.cp...

#InterprofessionalEducation

New publication co-authored by Wayne State EACPHS highlights evidence supporting Pyzchiva as a clinically equivalent biosimilar option for psoriasis, expanding access to care.
🔗 doi.org/10.1177/1060...

Piecing together fragmented care: An evaluation of a pharmacy-driven transitions-of-care service AbstractPurpose. Care fragmentation occurs when patients use multiple providers, health systems, and pharmacies, leading to polypharmacy, potentially inapp

New from WSU Pharmacy Practice faculty Hannah Ferrari & Amber Martirosov: Pharmacy tech–driven care coordination reduces med errors and improves post-discharge safety.
#PharmacyPractice #PatientSafety

doi.org/10.1093/ajhp...

Steatotic liver disease and cancer: from pathogenesis to therapeutic targets As environmental exposomes are changing with time, so are liver diseases around the globe. Due to an increasing prevalence of overnutrition and sedentary lifestyle in the global population, metabolic ...

New from WSU: Liu et al. review key molecular links between steatotic liver disease and cancer, identifying emerging therapeutic targets.

egastroenterology.bmj.com/content/3/3/...

Current Evidence and Gaps for Outpatient Respiratory Tract Infection Diagnostics: A Call to Action Abstract. Antimicrobial stewardship programs (ASPs) are underrepresented in outpatient settings, where antibiotic use and overprescribing are common. Upper

New from WSU researchers: A call to strengthen outpatient respiratory infection diagnostics to cut antibiotic overuse and improve care.
🔗 doi.org/10.1093/ofid...

Implementation of a Protocol With a Shortened Vancomycin Prophylaxis Duration is Associated With Reduced Acute Kidney Injury in Lung Transplant Recipients: A Quasi‐Experimental Study We evaluated implementation of a shortened post-operative vancomycin prophylaxis duration protocol on acute kidney injury (AKI) in lung transplant recipients. The intervention, modifying vancomycin (...

New from WSU’s College of Pharmacy & Health Sciences: Shortening vancomycin prophylaxis to 72h after lung transplant reduced kidney injury risk without more infections.
🔗 doi.org/10.1111/tid....

A cross-sectional analysis of doxyPEP use and outcomes in Michigan, United States - Christen J Arena, Nathan A Everson, Rachel M Kenney, Indira Brar, Smitha Gudipati, Nicholas Yared, Susan L Davis, Mi... Background: In 2024, national guidance was issued for doxycycline post-exposure prophylaxis (doxy-PEP) to prevent bacterial sexually transmitted infections (STI...

A new study from Michigan finds that doxyPEP (post-exposure doxycycline) is underused — even in populations at higher risk for bacterial STIs.

🔗 doi.org/10.1177/0956...

#PublicHealth #STIPrevention #Epidemiology

New collaborative study identifies 4-substituted phenylpyrazolidinone derivatives as potent inhibitors of Ku70/80-DNA-PK, a key enzyme in the DNA repair pathway.

🔗 doi.org/10.1039/d5md...

#MedicinalChemistry #DNARepair #Oncology #Pharmacology

A short 4–amino acid intracellular motif of the immune checkpoint protein VISTA directly inhibits growth receptor signaling (EGFR/HER2), suppressing tumor growth.

🔗 doi.org/10.1158/0008...

#Oncology #Immunotherapy #CancerBiology

Rapid deprotection and purification of ceftaroline free base from its phosphoramidate prodrug Contemporary pharmaceutical design often incorporates functional groups to improve the pharmacokinetic/pharmacodynamic profile of a desired active chemical entity. These compounds are known as prodrug...

A fast, non-enzymatic thermal method (90 °C for 15 min) efficiently converts the prodrug ceftaroline fosamil (Teflaro®) into its active form.

🔗 doi.org/10.1099/jmm....

#Antibiotics #PharmacyResearch #DrugDiscovery

A clever microbiology nudge—a simple comment added to lab reports—led to a 4.6× increase in use of narrow-spectrum antibiotics for Streptococcus pneumoniae bloodstream infections.

🔗 doi.org/10.1017/ash....

#AntibioticStewardship #BehavioralScience #Microbiology

Near-infrared light at 750 & 950 nm reduces mitochondrial hyperactivity and oxidative stress after simulated ischemia/reperfusion.

A simple, non-drug approach that speeds mitochondrial recovery and limits cell death — potential implications for stroke therapy.

🔗 doi.org/10.3390/anti...

📚 New in RSAP by Wayne State EACPHS and colleagues: Core journals in #PharmacyPractice—developed using theory + data to define the field’s scholarly boundaries.

A must-read for faculty, editors, & promotion committees.

🔗 doi.org/10.1016/j.sa...

#PharmEd #AcademicPublishing

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

💉 New in JICM: Long-acting insulin does not increase hypoglycemia risk in ICU patients with diabetes.

A promising insight for safe glycemic control during critical illness. 🏥

journals.sagepub.com/doi/10.1177/...

#ICU #PharmacyResearch #DiabetesCare

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

🚨 MDR Gram-negatives?
Aztreonam–avibactam may be the answer.

WSU EACPHS faculty and students review the current evidence in Pharmacotherapy 🧫

🔗 journals.sagepub.com/doi/10.1177/...

#PharmacyResearch #MBL #AntimicrobialStewardship #InfectiousDiseases

Burnout to balance: A dual-pharmacist couple’s story of career and family resilience We first met the summer before starting pharmacy school at the Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University. Excited

Burnout to balance 💥💗

Wayne State EACPHS PharmD alumni Drs. Krystle & Josh Raub reflect on their dual-pharmacist life & how they reclaimed joy, purpose, & family.

Read their story: doi.org/10.1093/ajhp...

#Pharmacy #Wellness #CareerBalance

Wayne State EACPHS applauds Frappa et al.’s sustained impact + calls for next-gen analytics (e.g., DiD, PSM, Bayesian ITS).

Smart stewardship = saved antibiotics, preserved outcomes. 👏

🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...

#IDPharmD #AntibioticStewardship #InfectiousDiseases #PublicHealth

Impact of an Interruptive Alert on the Number of Women Receiving CDC-Recommended Therapy for Trichomoniasis Background: The 2021 Centers of Disease Control and Prevention (CDC) sexually transmitted infection treatment guidelines recommend a 7-day course of metronidazole or single-dose tinidazole for women w...

An EHR-based alert improved adherence to CDC-recommended trichomoniasis therapy. Smart tech, better outcomes. Wayne State EACPHS

pmc.ncbi.nlm.nih.gov/articles/PMC...

#DigitalHealth #PharmacyPractice

Neural correlates of forward and backward walking in MS: insights from myelin water imaging - Experimental Brain Research Mobility impairments and increased fall risk are common in multiple sclerosis (MS), resulting from myelin degradation in motor pathways. While forward walking is a common mobility assessment, backward...

Walking forward or backward engages different brain pathways—myelin water imaging at Wayne State EACPHS reveals novel insights in MS.

link.springer.com/article/10.1...

#Neuroscience #MultipleSclerosis

Is Shorter Better in Oncology Patients, Too? A Retrospective Cohort Study of Short- Versus Long-Course Antibiotic Therapy for Uncomplicated Infections in Solid Tumor Patients Receiving Care in Ambulat... This retrospective cohort study evaluated short- versus long-course antibiotics for uncomplicated infections in ambulatory solid tumor patients. Among 303 patients, outcomes were similar between group...

Re-evaluating duration: For stable cancer patients, short-course antibiotics may reduce side effects without compromising care. Wayne State EACPHS

pmc.ncbi.nlm.nih.gov/articles/PMC...

#InfectionControl #CancerCare

Eravacycline use in immunocompromised patients: multicenter evaluation of timely versus late initiation on clinical outcomes | Microbiology Spectrum This multicenter, retrospective study evaluates the impact of timely versus late initiation of eravacycline (ERV) in immunocompromised patients with multidrug-resistant (MDR) bacterial infections. Imm...

Starting eravacycline sooner saves lives. This multicenter study led by Wayne State EACPHS shows earlier use improves clinical outcomes in vulnerable patients.

journals.asm.org/doi/10.1128/...

#PharmacyResearch #IDPharmacy

Assessment is more than a checkbox. This research by Wayne State EACPHS and colleagues uncovers how pharmacy faculty interpret COEPA strategies—what’s working, what’s not.

www.ajpe.org/article/S000...

#AcademicMedicine #TeachingExcellence