Christine Rabinak, PhD, MBA

As a neuroscientist who runs clinical trials—and someone living with metastatic breast cancer—I’m interested in collaborating with research teams as a patient research advocate.

Scientific + lived experience perspectives matter.

#PatientAdvocacy #ClinicalTrials #MetastaticBreastCancer

The first time you start a research lab, there’s no manual.

So I made one.

A practical toolkit for postdocs and early-career faculty launching their first lab: hiring, startup planning, collaborations, and building a sustainable research program.

zenodo.org/records/1888...

#research #postdoc

New research from WSU EACPHS shows that disruption of mitochondrial dynamics can trigger liver injury and tumor development through mitochondrial stress and inflammatory signaling.

#LiverDisease #CancerResearch

doi.org/10.1172/jci1...

New research from WSU EACPHS highlights how an academic–public health partnership built a genomic surveillance pipeline to track SARS-CoV-2 variants across Southeast Michigan and support pandemic response efforts.

#PublicHealth #Genomics #COVID19

doi.org/10.1038/s415...

Aspirin Deprescribing Interventions for Primary Prevention: A Systematic Review and Proposed Guidance for Deprescribing Recent literature indicates that the benefits of aspirin use for primary prevention of atherosclerotic cardiovascular disease (ASCVD) may be equivocal to the risk. This has resulted in several organi....

New research from WSU EACPHS reviews strategies to deprescribe aspirin used for primary prevention of cardiovascular disease and proposes an evidence-informed algorithm to guide clinical decision-making.

#PharmacyResearch

doi.org/10.1002/phar...

Study shows D-512 protects dopaminergic cells from rotenone-induced oxidative stress and mitochondrial dysfunction — supporting its potential in Parkinson’s disease.

Research from WSU EACPHS.

#ParkinsonsDisease #Neurodegeneration

doi.org/10.3390/jpm1...

EBPS2023 special issue: Stress, trauma and cannabinoids - Psychopharmacology Psychopharmacology -

Excited to share the Psychopharm Special Issue on Stress, Trauma & Cannabinoids 14 papers examining how the endocannabinoid system shapes stress & trauma responses.

Guest edited with @connorhaggarty.bsky.social, @mayoonthebrain.bsky.social & Christelle Baunez.

link.springer.com/article/10.1...

Study shows gabapentinoids are associated with increased respiratory depression risk in hospitalized CKD patients — highlighting need for careful dosing and monitoring.

Research from WSU EACPHS.

#MedicationSafety #ChronicKidneyDisease

doi.org/10.1177/1060...

Study shows the PNPLA3 148M variant exacerbates alcohol-induced liver injury and tumorigenesis — activating oncogenic pathways and impairing detoxification.

Research from WSU EACPHS.

#HepatocellularCarcinoma #LiverDisease

doi.org/10.1016/j.aj...

Clinical efficacy and safety of eravacycline for the treatment of enterococcal infections: a subpopulation analysis - BMC Infectious Diseases BMC Infectious Diseases - Infections due to Enterococcus faecalis and Enterococcus faecium are common in the hospital setting and carry a high risk for morbidity and mortality. Furthermore, the...

Subpopulation analysis shows eravacycline achieved 77% clinical cure in enterococcal infections, nearly half VRE, with favorable safety.

Research from WSU EACPHS.

#AntimicrobialResistance #InfectiousDisease

link.springer.com/article/10.1...

Bile acid analogs targeting C. difficile spore germination safely altered bile acid homeostasis in vivo — supporting prophylactic development.

Research from WSU EACPHS.

#ClostridioidesDifficile #TranslationalScience

doi.org/10.3390/biom...

Modified OPAT regimens in MDRO infections are associated with higher costs, discharge delays & prolonged LOS, with opportunities for oral-switch therapy.

Research from WSU EACPHS.

#AntimicrobialStewardship #TransitionsOfCare

doi.org/10.1093/ofid...

Backward walking speed strongly predicts daily step goal achievement in people with MS — offering a practical clinical mobility measure.

Research from WSU EACPHS.

#MultipleSclerosis #PhysicalActivity

doi.org/10.1177/1545...

A stability-indicating RP-HPLC method for the simultaneous quantification of brimonidine tartrate and timolol maleate in bulk drug substances and pharmaceutical dosage forms - Scientific Reports Scientific Reports - A stability-indicating RP-HPLC method for the simultaneous quantification of brimonidine tartrate and timolol maleate in bulk drug substances and pharmaceutical dosage forms

Validated stability-indicating RP-HPLC method for simultaneous quantification of brimonidine tartrate & timolol maleate — supporting quality control and greener analytical practices.

Research from WSU EACPHS.

#AnalyticalChemistry #PharmaceuticalSciences

www.nature.com/articles/s41...

An interruptive EHR alert significantly improved optimal antibiotic prescribing for acute bacterial sinusitis (7% ➡️ 30%).

Outpatient stewardship innovation from WSU EACPHS.

#AntimicrobialStewardship #DigitalHealth

doi.org/10.1017/ash....

New framework (IDEAL-R) provides guidance for evaluating the educational impact and sustainability of OSCEs in pharmacy curricula.

Education scholarship from WSU EACPHS.

#PharmacyEducation #HealthProfessionsEducation
doi.org/10.1016/j.aj...

Daily EMA data show dynamic, bidirectional relationships between psychoactive substance use and symptoms in people with MS — improving understanding of real-world symptom regulation.

Research from WSU EACPHS.

#MultipleSclerosis #MSResearch
doi.org/10.1016/j.ap...

Implementation of a Protocol With a Shortened Vancomycin Prophylaxis Duration is Associated With Reduced Acute Kidney Injury in Lung Transplant Recipients: A Quasi‐Experimental Study We evaluated implementation of a shortened post-operative vancomycin prophylaxis duration protocol on acute kidney injury (AKI) in lung transplant recipients. The intervention, modifying vancomycin (...

A shortened 72-hour vancomycin prophylaxis protocol in lung transplant recipients was associated with lower odds of acute kidney injury — with similar infectious outcomes.

Research from WSU EACPHS.

#AntimicrobialStewardship #TransplantMedicine

doi.org/10.1111/tid....

Novel 5,6-fused heterocycle cholate derivatives inhibited C. difficile spore germination — and one compound prevented infection in a murine model.

Important translational work from WSU EACPHS.

#MedicinalChemistry #CDI

doi.org/10.1016/j.bm...

Methodological Approaches for Extraction, Chromatographic and Mass Spectrometric Analysis of Lipids Lipids are a diverse class of molecules that mediate numerous structural and functional properties of cells, including trafficking, regulation of membrane proteins, and subcellular compartmentalizati...

Comprehensive review of lipid extraction, chromatography, and mass spectrometry approaches in lipidomics — emphasizing standardization and emerging opportunities like MS imaging and single-cell analysis.

Research from WSU EACPHS.

#Lipidomics #AnalyticalScience

doi.org/10.1002/bmc....

Pharmacist-driven discharge antibiotic interventions improved prescribing appropriateness from 21.8% to 50% in community hospitals — without increasing 30-day adverse outcomes.

Important antimicrobial stewardship research from WSU EACPHS.

#AntibioticStewardship #Pharmacy

doi.org/10.1093/ajhp...

EBPS2023 special issue: Stress, trauma and cannabinoids - Psychopharmacology Psychopharmacology -

What an undertaking this was. So proud of the collection @mayoonthebrain.bsky.social , @brainsbeesbikes.bsky.social , @cbaunez.bsky.social and I collected for the “Stress, Trauma and Cannabinoids” special issue in @psychopharmacology.bsky.social
Editorial: link.springer.com/article/10.1...

@acnporg.bsky.social #ACNP2026

Impact of Pseudomonas aeruginosa biofilm exopolysaccharide composition on bacteriophage and bacteriophage-antibiotic combination activity | Antimicrobial Agents and Chemotherapy Healthcare-associated infections pose a significant health risk for inpatients. The Centers for Disease Control and Prevention estimates that there are over 1.7 million healthcare-associated infection...

Wayne State EACPHS tested how Pseudomonas aeruginosa biofilm phenotype (Psl- vs Pel-rich) shapes the activity of a 3-phage cocktail (EM, EC, 109) ± ciprofloxacin against MDR/XDR biofilms.

doi.org/10.1128/aac....

#AMR #Pseudomonas #Biofilms #PhageTherapy #InfectiousDiseases

We’re testing whether low-dose THC given before key Prolonged Exposure sessions can boost fear extinction, engage vmPFC–hippocampal circuits, and improve PTSD outcomes in a randomized, double-blind trial.

doi.org/10.1016/j.cc...

#PTSD #THC #ExposureTherapy #ClinicalTrials

Proteomic and Functional Analysis on Endothelial Cell Heterogeneity Identifies Key Regulators in Hyperglycemia-Induced Dysfunction. | American Journal of Physiology-Cell Physiology | American Physiological Society Endothelial cells (ECs) play a critical role in managing vascular homeostasis and neovascularization. EC functions vary significantly depending on their anatomic locations, especially for ECs forming macrovascular versus microvascular vessels. ECs possess heterogeneous signaling pathways, energy metabolism, and cellular behaviors that enable them to handle both physiological and hyperglycemic conditions. These variations can impact the efficacy of pharmacotherapy and influence the likelihood of unexpected side effects. In this study, we compared human aortic ECs (HAECs) and human dermal microvascular ECs (HDMVECs) to observe the functional and proteomic differences potentially contributing to EC heterogeneity. Compared to HAECs, HDMVECs exhibited faster proliferation, but lower migration and permeability. Under high glucose, migration was worsened for both cell types, whereas proliferation was unaffected, and permeability increased for HDMVECs. Using proteomic analysis, we identified 126 proteins whose abundance was significantly different between HAECs and HDMVECs. DAVID analysis revealed their biological processes, cellular compartments, molecular functions, and pathways. under high glucose, WARS1 increased while SOD2 decreased. Reversing WARS1 or SOD2 expression levels improved HDMVEC migration and permeability functions. The combined treatment of WARS1 knockdown and SOD2 overexpression fully restored EC migration and reduced permeability to levels comparable to those of their counterparts under normal glucose conditions. Furthermore, in the cutaneous wound in type 2 diabetic mice, the combination therapy of Wars1 knockdown and SOD2 overexpression accelerated the wound closure and augmented wound angiogenesis. Our studies provide novel molecular insights into EC heterogeneity and identified WARS1 and SOD2 as potential targets for dermal angiogenesis during tissue repair.

Wayne State EACPHS shows microvascular ECs are more vulnerable to high-glucose stress.
🔗 doi.org/10.1152/ajpc...

#Diabetes #VascularBiology #Proteomics

Assessing Pharmacists’ Use and Perception of AI Chatbots in Pharmacy Practice: Cross-Sectional Survey Study Background: The use of artificial intelligence (AI)–based large language model chatbots such as ChatGPT has become increasingly popular in many disciplines. However, concerns exist regarding ethics, l...

Wayne State EACPHS and colleagues surveyed pharmacists on AI chatbot use.
Only 30% have used AI tools like ChatGPT, but 51.5% plan to begin.
Top uses: summarization, LOR writing & disease info — not patient care decisions.
🔗 doi.org/10.2196/71767
#Pharmacy #AIinHealthcare #DigitalHealth

Wayne State EACPHS highlight how age-related physiologic changes, polypharmacy, and financial barriers impact pulmonary care in older adults.
Proper device selection + inhaler technique + Medicare navigation = better outcomes.
🔗 doi.org/10.1016/j.cg...

#Geriatrics #PulmonaryCare #PharmacyResearch

Whole-genome analysis of extensively drug-resistant Enterobacter hormaechei isolated from two hospitalized patients in the United States: A case series of a rare but rising threat AbstractBackground. New Delhi metallo-beta-lactamases (NDM) confer extensive antibiotic resistance, complicating treatment and leading to poor outcomes. In

Wayne State EACPHS report two NDM-5–producing, extensively drug-resistant Enterobacter hormaechei isolates in Southeast Michigan--highlighting a rare but rising threat and the value of genomic surveillance.

🔗 doi.org/10.1093/jaca...

#AMR #CRE #NDM #PharmacyResearch