Oliver Grant

Thanks Elisa!

This is excellent, the gradients and highlighting look great.

A few GlycoDraw-related highlights of the upcoming glycowork v1.6 update (dropping in a few weeks):
- our very own rendering engine (GlycoDraw for the masses, thanks to glycorender!);
- SNFG-gradients;
- automated Alt text;
- reverse-highlighting;
- even more support for highly complex sequences

Or go directly via url: glycam.org/url/condensed/[4DGlcpb1-6[DNeup5Aca2-3DGalpb1-4]DGlcpNAcb1-3DGalpb1-]<25>OH

You can now use repeat units, so to build 25 repeats of the capsular polysaccharide from group B streptococcus (serotype III) you go to glycam.org/txt and enter
[4DGlcpb1-6[DNeup5Aca2-3DGalpb1-4]DGlcpNAcb1-3DGalpb1-]<25>OH.

Generating 3D Models of Carbohydrates with GLYCAM-Web The carbohydrate 3D structure-prediction tools (builders) at GLYCAM-Web (glycam.org) are widely used for generating experimentally-consistent 3D structures of oligosaccharides suitable for data interp...

After 20 years and a recent big overhaul we're finally publishing the carbohydrate 3D structure builders on GLYCAM-Web (glycam.org)! Pre-print: (www.biorxiv.org/content/10.1...) #glycotime tools

Glycoproteins, Glycolipids, or Both: Why do Glycosyltransferases Recognize Different Acceptors? Glycosylation is an important post-translational modification catalyzed by glycosyltransferases (GTs), which comprise a large group of enzymes with diversified specificity. Most GTs show high specifi...

Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

"A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor"

www.nature.com/articles/s41...

PhD Position in Virus-Glycan Interactions If you're ready to solve virus-glycan interaction puzzles and shape the future of novel in vitro models, join us!

I have a PhD position open in my lab! viruses and glycans... who does not love that combo😉. Please share!. #glycotime #lovevirology www.uu.nl/en/organisat...

Polysialylation is a general feature of immune activation Sialic acids are critical regulators of immune responses and the sialic acid-Siglec axis has receive much attention recently for it role as a new immune checkpoint. While α2,3- and α2,6-linked sialosi...

Polysialic acids are upregulated on activated T cells #glycotime

MagLOV!

MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.

We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).

bsky.app/profile/addg...

The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors H5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of h...

We have a new preprint on the receptor specificity of 2.3.4.4 H5 viruses. We introduced the hallmark Q226L mutation in several antigenic backgrounds and observed different phenotypes. #H5N1 #glycotime www.biorxiv.org/content/10.1...

Surface Structures of Group B Streptococcus Important in Human Immunity | Microbiology Spectrum ABSTRACTThe surface of the Gram-positive opportunistic pathogen Streptococcus agalactiae, or group B Streptococcus (GBS), harbors several carbohydrate and protein antigens with the potential to be eff...

Figure 3 needs a strobe effect warning. I find deducing carbohydrate structure from ChemDraw images hard enough, I don't need this!
journals.asm.org/doi/10.1128/...