Jim Johnson 🇨🇦

Folks are looking for a place to have serious scientific and professional conversations without massive bot farms. That’s the coding :)

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

Here deletion of Xbp1 in β-cells (Xbp1β-/-) of non-obese diabetic mice before insulitis is protective against #diabetes
www.nature.com/articles/s41...

Thank you Krista. I accept it on behalf of my wonderful team and the mentors who shaped me along the way

No lawmaker in Congress should be able to buy, own, and sell individual stocks. Period. Let's make Congressional stock trading illegal.

The consequences of misinformation are real and often tragic #vaccines #measles www.nature.com/articles/d41...

Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...

New work from @thompsonisletlab.bsky.social

link.springer.com/article/10.1...

Ask an expert: How can I manage my type 1 diabetes? Approximately 300,000 Canadians live with type 1 diabetes, an autoimmune disorder with no known cure. Type 1 diabetes can pose serious challenges, but ongoing research is improving the quality of life for those with this chronic condition. Endocrinologist Dr. Breay Paty discusses the effects of low and high blood sugar, as well as science-backed management strategies and emerging biological treatments for type 1 diabetes.

This #WorldDiabetesDay, discover the effects of low & high blood sugar, as well as science-backed management strategies & emerging treatments for type 1 diabetes from VCHRI expert Dr. Breay Paty:

The New York Times is now a garbage rag of bothsidesism. Embarrassing

Talk poster

We are delighted to host the 2nd Annual Susie Clee Memorial Lecture this Thursday 4pm PST which will be given by Dr Melkem Kebede of the University of Sydney.

Will GLP-1 medicines modify the rates and/or outcomes of one or more #cancers A review on the biology, limitations of the data and the road ahead from @lwellberg.bsky.social and colleagues in JCI www.jci.org/articles/vie...

FIN!

FIN and Bruce

Super excited for the announcement that the Canucks for Kids Fund will be supporting (and re-naming) the Breakthrough T1D Centre of Excellence at @ubc.bsky.social @ubccps.bsky.social @bcch-mri-research.bsky.social @bcdiabresnet.bsky.social @vchresearch.bsky.social

💪 Fueled by historic philanthropic support, VCHRI has scaled up its research capacity with the launch of two landmark research institutes — Dilawri Cardiovascular Institute & M. H. Mohseni Institute of Urologic Sciences in 2024/2025: www.vchri.ca/our-res... #DidYouKnow #AtAGlance

“Terrible things are happening outside. Poor helpless people are being dragged out of their homes. Families are torn apart. Men, women, and children are separated. Children come home from school to find that their parents have disappeared.”

Diary of Anne Frank
January 13, 1943

Joke country

Podcast graphic with EASD logo. A man (Prof. Andrew Hattersley, 2025 Claude Bernard Prize recipient) in glasses and suit speaks into a microphone labelled ‘EASD Live’. Soundwave graphic below with the title ‘Precision diabetes’ on a blue background

💥🎙️ New Episode!!!

Prof. Andrew Hattersley ( @exeter.ac.uk), 57th EASD Claude Bernard #Prize recipient, shares how his work on #genetic forms of diabetes has transformed care worldwide & what’s next for #PrecisionMedicine .

🎧 Listen now: www.easd.org/media-centre...

#Diabetes #Research #podcast

If you want to hear from Jane Goodall tonight given the news, this podcast interview she did for Wiser Than Me earlier this year was really good.

Follow Gaia and welcome them to Bluesky!

Restoration of pancreatic beta cell identity and autophagy in KATP-induced diabetes by intermittent fasting - Diabetologia Aims/hypothesis The loss of pancreatic beta cell mass and identity is a hallmark of diabetes. While factors such as beta cell overwork (insulin hypersecretion) and elevated intracellular calcium have been implicated, beta cell identity loss also occurs in KATP gain-of-function (KATP-GOF) mice, a model of human neonatal diabetes, even in the absence of these factors. This suggests additional underlying mechanisms. Autophagy, a key process for cellular homeostasis, is impaired in the islets and beta cells of both type 1 and type 2 diabetes, but its role in monogenic diabetes with insulin secretory deficiency remains unclear. We hypothesise that autophagy dysfunction contributes to beta cell identity loss in KATP-GOF mice, and that intermittent fasting (IF) can restore autophagic flux, thereby preserving functional beta cell mass. Methods To test this, adult tamoxifen-inducible KATP-GOF mice and littermate controls were randomly assigned to two groups: (1) chow diet ad libitum; and (2) chow diet with alternate-day IF. Results KATP-GOF mice fed ad libitum developed severe hyperglycaemia due to impaired insulin secretion. This was followed by a reduction in insulin content, disruption of beta cell autophagic flux, autophagosome accumulation and, ultimately, the loss of beta cell identity and dedifferentiation. In contrast, KATP-GOF mice subjected to alternate-day IF exhibited lower blood glucose levels, improved mitochondrial morphology, restoration of autophagic flux and reestablishment of beta cell identity. Conclusions/interpretation This study provides the first evidence of autophagy impairment in non-obese, insulin secretory-deficient, KATP-induced diabetes mice and demonstrates that IF restores both autophagic flux and beta cell identity. This finding suggests that similar mechanisms may contribute to beta cell dysfunction in other forms of diabetes. Graphical Abstract

Based on studies of autophagy in non-obese, insulin secretory-deficient KATP-GOF mice the authors propose that #IntermittentFasting prevents the gradual loss of beta cell identity by enhancing autophagy link.springer.com/article/10.1...

A consensus guide to preclinical indirect calorimetry experiments - Nature Metabolism The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Towards establishing consensus standards to unify indirect calorimetry experiments and their analysis for more consistent, meaningful and reproducible results-the latest proposals www.nature.com/articles/s42...

#DidYouKnow that VCHRI is one of Canada’s top funded research organizations? With a total of $143 million in research funding for 2024/2025, VCHRI is leading health research in B.C. Discover key facts about our work #AtAGlance: www.vchri.ca/our-res...

This is an amazing training opportunity for PhD students and Postdocs with a great mentor doing cutting edge science at a fantastic university!

This is such an exciting project to be a part of with my new office-neighbour @yhcarolyang.bsky.social in @lsiexeter.bsky.social. Spread the word and let's find the ideal colleague to join us for this fully funded #PhD studentship!

Wonderful! Welcome to the community. Bluesky has starter packs of similar accounts to follow.

Hanna Boethius

@hannaboethius.bsky.social providing both a scientific and patient perspective on social media in T1D

🚨 Coming up at #EASD2025!

Join the EASD Early Career Academy session: "Scientific Communications on #socialmedia ... shall we enter the arena?" Chaired by Dr. Caterina Conte, with insights from:

@parthaskar.bsky.social
Hanna Boëthius
@jimjohnsonsci.bsky.social

A must-attend!

#Diabetes

Partha Kar

@parthaskar.bsky.social giving a masterclass on social media in diabetes

so in the last talk of the last session of the last day of #easd2025 there will be a talk about social media from the perspective of a scientist

@metabologiajnl.bsky.social am I the first submission?!

#FundingAnnouncement 📢 Expand your capacity for innovation-driven research that creates new health care knowledge by applying for a VCHRI Investigator Award! Registration closes Oct. 14: www.vchri.ca/service... @vghfdn.bsky.social @vchhealthcare.bsky.social @ubcmedicine.bsky.social