Jim Johnson 🇨🇦

It’s should be noted that insulin is still present in these experimental models, although at low levels. In work out of the Kieffer lab leptin was not able to rescue complete insulin deficient mice.

Guys y’all have the first overtly pro-cancer HHS leaders. Literal death cult. If I was an American, I’d be in the streets every day protesting

You have your answer. It’s obvious

The Big Beautiful Bill gives Meta a $15 billion check.

That’s more than our federal government spends on child care in an entire year.

If we invested that much in child care & early childhood education, we’d create stronger futures for everyone, not just Mark Zuckerberg.

chrome://external-file/JTB-2025-RYKMCL_highlighted4JJ.pdf JTB-2025-RYKMCL_highlighted4JJ.pdf from my colleague

The pictured individuals will learn (or should learn but probably can’t) a crucial lesson in the basics of international trade and diplomacy. Trade deals are never unilateral.

Interesting, thanks for sharing. Beta cell specific manipulation that reduces hyperinsulinemia with protection against heart failure

Huge surprise!

Have you already checked out our #EISG2025 program?
Fresh off the press! Download it here: eisg2025.se/scientific_p...

Photograph of Charlotte Ling.

Professor Charlotte Ling, from the #eisg2025 steering committee, introduces this year’s European Islet Study Group event in Malmö, Sweden. Lund University Diabetes Centre is the host of this year's meeting, and we are happy to see that over 250 researchers have registered for the meeting 👏

Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophy Skeletal muscle regeneration in chronic muscle diseases such as Duchenne Muscular Dystrophy (DMD) has remained clinically unsurmountable. Estrogen-related receptor alpha (ERRα) plays a critical role i...

Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophy
www.biorxiv.org/content/10.1...

AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates diverse growth signals to regulate cell and tissue growth. How the molecular mech…

AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth
www.sciencedirect.com/science/arti...

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether insulin causes these phenomena or is a compensatory response has remained unsettled for decades. We examined t...

nice paper by a large team led by @paulwfranks.bsky.social showing in humans what we showed in mice - reducing insulin production completely prevents liver fat accumulation www.cell.com/cell-metabol.... Insulin hypersecretion causes fatty liver in the IMI cohort. www.medrxiv.org/content/10.1...

New data on #BCAA metabolism in #T2D: although exercise has an insulin-sensitising effect, this does not appear to occur in tandem with improved BCAA clearance #DiabetesResearch #Endocrinology #MedSky

Earth is likely to cross a key climate threshold in two years A new World Meteorological Organization report spells the end of the world’s most famous climate goal.

Earth will warm 1.5 degrees Celsius above preindustrial levels in just two years, new data shows. Irreversible tipping points — like the melting of Arctic ice sheets or the collapse of coral reefs — are closer at hand than previously believed.

He’s had his dream job 3 times now! Swing and a miss for the big money though.

Jim Johnson

VCHRI research summit day.

90% of doing science is being open to new ideas.

Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes @natcomms.nature.com
www.nature.com/articles/s41...

There is one place, however, where Musk, with the help of his minions, achieved his goals. He did indeed shred U.S.A.I.D. Though a rump operation is now operating inside the State Department, the administration says that it has terminated more than 80 percent of U.S.A.I.D. grants. Brooke Nichols, an associate professor of global health at Boston University, has estimated that these cuts have already resulted in about 300,000 deaths, most of them of children, and will most likely lead to significantly more by the end of the year. That is what Musk’s foray into politics accomplished.

Musk should be asked about this in every interview he does now and forever. To ignore it is a dereliction of duty.

www.nytimes.com/2025/05/30/o...

Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @asaelroichman.bsky.social

Excellent point

Going with a local hero: Southern Resident Killer Whale! Only about 70 of them left in the Pacific Northwest, mainly due to their preferred diet being Chinook salmon. Pollution (including noise), are also factors. They are culturally iconic, and spiritually important to PNW Indigenous peoples.

Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...

Proinflammatory cytokine-induced alpha cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism - Diabetologia Aims/hypothesis In type 1 diabetes, the counterregulatory glucagon response to low plasma glucose is impaired. The resulting increased risk of hypoglycaemia necessitates novel strategies to ameliorate...

Long-term cytokine exposure of human islet micro tissues created a type 1 diabetes-like phenotype with impaired low-glucose-induced glucagon secretion, with attenuation by GIP @diabetologiajnl.bsky.social link.springer.com/article/10.1...

Role of the translation factor EIF2A in protecting #BetaCells during #ERStress #DiabetesResearch #Isets #MedSky @jimjohnsonsci.bsky.social @bruceverchere.bsky.social

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition - Diabetologia Aims/hypothesis The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A...

New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...

Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment https://www.biorxiv.org/content/10.1101/2025.05.01.651733v1

"The turbines spew NOx at an estimated rate of 1,200 to 2,000 tons a year — far more than the gas-fired power plant across the street or the oil refinery down the road."

I don't see how ppl rationalize any use for AI when the costs so clearly outweigh the benefits. It's a health-destroying machine.

Data centers are the new sacrifice zones