Neuropsychopharmacology

a woman is talking to a man with the words time well spent below her ALT: a woman is talking to a man with the words time well spent below her

That's all for now, but don't forget - time reading #ThisWeekInNPP is time well spent ⌛️

#TWiNPP

From Murata & Berridge, subregions of the olfactory tubercle contribute to modulating hedonic reactions to sweetness and flavor perception in 🐀

www.nature.com/articles/s41...

#TWiNPP

In this research highlight, Kawa & Robinson discuss evidence that escalation of cocaine intake is more driven by sensitization of incentive salience, providing insight into early development of addiction vulnerability 📈

www.nature.com/articles/s41...

Maternal immune activation in mice recapitulates features of attention-deficit/hyperactivity disorder (ADHD) in susceptible offspring - Neuropsychopharmacology Neuropsychopharmacology - Maternal immune activation in mice recapitulates features of attention-deficit/hyperactivity disorder (ADHD) in susceptible offspring

#TWiNPP

From Schaer et al., prenatal exposure to maternal immune activation in 🐭 reflects key features of ADHD in a susceptible subset of offspring

www.nature.com/articles/s41...

#TWiNPP

In a longitudinal study, Skumlien et al. link cannabis use to blunted reward anticipation signaling, a neural pattern associated with addiction and anhedonia 🧠 / @mattwall.bsky.social

www.nature.com/articles/s41...

Comparing affective bias modification by first- and second-generation antidepressants in male rats using a translational behavioural task - Neuropsychopharmacology Neuropsychopharmacology - Comparing affective bias modification by first- and second-generation antidepressants in male rats using a translational behavioural task

#TWiNPP

Kamenish et al. demonstrate that different antidepressants modify affective biases through distinct mechanisms, which may contribute to variability in clinical onset and efficacy 💊

www.nature.com/articles/s41...

#TWiNPP

Mattey-Mora et al. show that integrated neurobiological and environmental models better predict adolescent risk for substance use disorders in a longitudinal study 🧠 / @joeyaloimdphd.bsky.social

www.nature.com/articles/s41...

Sensorimotor circuit connectivity as a candidate biomarker for responsiveness to sertraline in obsessive–compulsive disorder - Neuropsychopharmacology Neuropsychopharmacology - Sensorimotor circuit connectivity as a candidate biomarker for responsiveness to sertraline in obsessive–compulsive disorder

#TWiNPP

From Bai et al., resting-state connectivity in the sensorimotor circuit may serve as a candidate biomarker of SSRI response in OCD 💊

www.nature.com/articles/s41...

The neurobiological cravings signature (NCS) as a predictive neuromarker of clinical outcomes in alcohol use disorder - Neuropsychopharmacology Neuropsychopharmacology - The neurobiological cravings signature (NCS) as a predictive neuromarker of clinical outcomes in alcohol use disorder

#TWiNPP

Lofberg et al. evaluate the neurobiological cravings signature (NCS), an fMRI-based machine learning marker, as a predictor of outcomes in alcohol use disorder 🧠 / @neuroip.bsky.social

www.nature.com/articles/s41...

The clocks may have changed this weekend (at least in North America) 🕓 but one thing always remains constant - another stellar lineup of NPP articles is here 🤩 #ThisWeekInNPP

#TWiNPP

Inactivation of NMDAR and CaMKII signaling within the prelimbic cortex blocks incubated cocaine- and sucrose-craving Neuropsychopharmacology - Inactivation of NMDAR and CaMKII signaling within the prelimbic cortex blocks incubated cocaine- and sucrose-craving

Incubated craving of cocaine or sucrose in 🐀 depends on NMDAR and calcium/calmodulin-dependent protein kinase II signaling in the prelimbic cortex, with cocaine craving specifically associated with increased kinase activity

Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats Neuropsychopharmacology - Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation...

In ♂️🐀 pre-surgical stress exacerbated & prolonged somatosensory hypersensitivity, pain-related aversion & anxiety via enhanced spinal microglial NLRP3–interleukin-1β signaling, with effects mediated by β-adrenergic receptor activation

Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based multivariate pattern analysis Neuropsychopharmacology - Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based...

Using MVPA of resting-state fMRI identify 🧠 features to distinguish MDD patients with versus without a history of suicide attempts, findings implicate disrupted sensory–cognitive integration as a link from trauma to suicide risk in MDD

Modulation of hierarchical motor sequence learning by alpha-synuclein and the adenosine A2A receptor Neuropsychopharmacology - Modulation of hierarchical motor sequence learning by alpha-synuclein and the adenosine A2A receptor

This study explored how alpha-synuclein aggregation in the SNc disrupts executive function in Parkinson’s disease using a hierarchical motor sequence learning paradigm, finding adenosine A2A receptors as a promising therapeutic target 💊

That's all for this for #TWiNPP - see you the same time, same place, next week (and every week after)

Pharmacotherapy of major depressive disorder in older adults: from an evidence-informed stepwise algorithm to precision medicine Neuropsychopharmacology - Pharmacotherapy of major depressive disorder in older adults: from an evidence-informed stepwise algorithm to precision medicine

#TWiNPP

A review from Lenze et al., focuses on an evidence-informed stepwise algorithm for approaching precision pharmacotherapy for late-life depression (LLD) 💊

Transcriptional profiles of antidepressant resistance across the corticolimbic pathway of chronically stressed mice Neuropsychopharmacology - Transcriptional profiles of antidepressant resistance across the corticolimbic pathway of chronically stressed mice

#TWiNPP

Gyles et al. use a 🐭 model of treatment-resistant MDD (TRD) & RNA sequencing to reveal transcriptional signatures associated with antidepressant treatment / Angélica Torres-Berrío, PhD @sinaibrain.bsky.social Eric Nestler Eric Parise

Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial Neuropsychopharmacology - Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial

#TWiNPP

From Jin et al., an individualized task-guided accelerated continuous theta burst stimulation strategy targeting the right dorsolateral prefrontal cortex shows efficacy in alleviating depressive and anxiety symptoms while improving social dysfunction in MDD 🧠

We're back with another run down of what's new #ThisWeekInNPP

See below for the latest on continuous theta burst stimulation, transcriptional signatures from a mouse model of TRD, and a precision pharmacotherapy for late-life depression 👇

#TWiNPP

Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression Neuropsychopharmacology - Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression

In this review, the authors examine factors contributing to depressive episode recurrence following remission in late-life depression, integrating evidence across cognitive, behavioral, social, environmental, and neuroimaging domains 🧠

From rest to focus: pharmacological modulation of the relationship between resting state dorsal attention network dynamics and task-based brain activation Neuropsychopharmacology - From rest to focus: pharmacological modulation of the relationship between resting state dorsal attention network dynamics and task-based brain activation

Do resting-state dynamics network predict task-evoked 🧠 responses under pharmacological modulation?

Findings suggest intrinsic network dynamics influence drug-specific modulation of cognitive control & may support individualized txt

Central amygdalar PKCδ neurons mediate fentanyl withdrawal Neuropsychopharmacology - Central amygdalar PKCδ neurons mediate fentanyl withdrawal

Circuit mapping of PKCdelta–expressing neurons in the lateral capsule of the CeA identified opioid-sensitive inputs, implicating central amygdala protein kinase C-delta neurons as key mediators of the somatic features of opioid withdrawal

In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain Neuropsychopharmacology - In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain

This study examined mGluR5 availability in individuals with & without chronic pain across psychiatric diagnoses; ⬇️ availability was associated with ⬆️ depression, anxiety, & executive dysfunction, highlighting mGluR5 as a potential treatment target

Thanks for the shoutout! We're very excited to share this review!

And that's a wrap for this week!

Join us next Tuesday for the next installment of This Week in NPP #TWiNPP

The sodium leak channel NALCN in Drd2+ striatal neurons regulates neuronal excitability, locomotion and food-seeking in a sex-dependent manner Neuropsychopharmacology - The sodium leak channel NALCN in Drd2+ striatal neurons regulates neuronal excitability, locomotion and food-seeking in a sex-dependent manner

#TWiNPP

Castell et al. demonstrate that the sodium leak channel NALCN in dopamine D2 receptor-expressing striatal neurons modulates response to anti-dopaminergic treatments in a sex-specific manner

Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity Neuropsychopharmacology - Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity

#TWiNPP

From Kuang et al., a machine learning study that suggests that stress-related neurotoxicity may contribute to cognitive decline in PTSD / Anthony Chesebro

Psilocybin improves novel object recognition in a rat model of Fragile X Syndrome through the modulation of the BDNF/TrkB signaling pathway Neuropsychopharmacology - Psilocybin improves novel object recognition in a rat model of Fragile X Syndrome through the modulation of the BDNF/TrkB signaling pathway

#TWiNPP

Ascone et al. show that psilocybin microdosing rescues recognition memory deficits, potentially via neurotrophic signaling, in a mouse 🐀 model of Fragile X Syndrome

#TWiNPP

Olu Ajilore, MD, PhD and Dr. Reynolds underscore key contributors to heterogeneity in later life and highlight importance of computational psychiatry and implementation science for developing tractable real-world solutions

Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity Neuropsychopharmacology - Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity

#TWiNPP

Tan et al. show that adaptive harm avoidance is dependent on a time-sensitive window of GABA-mediated inhibition of VTA dopamine neurons during punishment learning