Emily Condiff

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion - Nature Isotropic tissue magnification is integrated with matrix-assisted laser desorption/ionization mass spectrometry imaging to enable untargeted spatial proteomics at micrometre resolution and with high protein identification rates in multiple tissue types.

Nature research paper: iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

go.nature.com/4qRtP6F

50 years ago, the Edmund Fitzgerald, a 'rock star' ship, sank in Lake Superior Twenty-nine sailors drowned when the Edmund Fitzgerald went down in the Great Lakes' icy waters on Nov. 10, 1975. The ship was immortalized in a surprise hit 1976 folk ballad by Gordon Lightfoot.

Good NPR story on the occasion of the 50th anniversary of the Edmund Fitzgerald on Lake Superior.

www.npr.org/2025/11/06/n....

1/2

🔊 Listen Now: 50 years ago, the Edmund Fitzgerald, a 'rock star' ship, sank in Lake Superior Morning Edition on NPR One | 5:03

An important anniversary for Minnesotans everywhere: 50 years ago, the Edmund Fitzgerald, a 'rock star' ship, sank in Lake Superior
one.npr.org/i/nx-s1-5518...

James Watson, dead at 97, was a scientific legend and a pariah among his peers James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.

A Sharon Begley byline, almost 5 years after her death.

Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."

Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫

Structural immunity: immune cells as architects of tissue barriers - Nature Reviews Immunology This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...

NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky

“America is the wealthiest nation on Earth, but its people are mainly poor, and poor Americans are urged to hate themselves. To quote the American humorist Kin Hubbard, 'It ain’t no disgrace to be poor, but it might as well be.' It is in fact a crime for an American to be poor, even though America is a nation of poor. Every other nation has folk traditions of men who were poor but extremely wise and virtuous, and therefore more estimable than anyone with power and gold. No such tales are told by the American poor. They mock themselves and glorify their betters. The meanest eating or drinking establishment, owned by a man who is himself poor, is very likely to have a sign on its wall asking this cruel question: 'if you’re so smart, why ain’t you rich?' There will also be an American flag no larger than a child’s hand – glued to a lollipop stick and flying from the cash register. Americans, like human beings everywhere, believe many things that are obviously untrue. Their most destructive untruth is that it is very easy for any American to make money. They will not acknowledge how in fact hard money is to come by, and, therefore, those who have no money blame and blame and blame themselves. This inward blame has been a treasure for the rich and powerful, who have had to do less for their poor, publicly and privately, than any other ruling class since, say Napoleonic times. Many novelties have come from America. The most startling of these, a thing without precedent, is a mass of undignified poor. They do not love one another because they do not love themselves.”

reading slaughterhouse 5 for the first time and i was absolutely knocked senseless by this passage, which is so true and relevant that it feels like it was pulled from a history book

A human placenta model to protect pregnant women and their babies | EMBL EMBL researchers were awarded a BII foundation grant to support Model-MI – an in vitro model that mimics the maternal-fetal interface.

EMBL Barcelona researchers develop a human placenta model to protect pregnant women and their babies.

This in vitro model that mimics the maternal-foetal interface of the placenta, allowing for the study of molecule exchange and drug transport.

www.embl.org/news/science...

Lab mice can now have periods like humans Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders

The mice could be used to better understand and treat heavy menstrual bleeding, and study reproductive health conditions such as endometriosis. https://scim.ag/473mwRw

From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...

Second "No Kings Day" protests likely the largest single-day political demonstration since 1970, with 4.2-7.6 million participants Here are the initial results from our crowdsourced crowd-counting estimates

Good evening. We estimate that between 4.2 and 7.6 million people turned out for the No Kings Day demonstrations held around the country on Saturday. This makes Oct 18 very likely the biggest single-day U.S. protest event since 1970. www.gelliottmorris.com/p/second-no-...

Acne vaccines could offer robust defence Researchers are hoping to trick the immune system into fighting back against the bane of adolescents everywhere.

Treatments for acne offer only partial and temporary reductions in symptoms – but two vaccine candidates could offer new hope. This article is part of our Nature Outlook on Skin. 🧪

BOSTON… (those are people, not ants)

#NoKingsInAmerica 🇺🇸

BOSTON SHOWING UP TO TELL DONALD TRUMP #NOKINGS 🤴🚫

This One Matters: A "No Kings" Protest Guide For Oct 18 and beyond ...

This is an excellent article on what you need to know if you attend any of the #NoKings protests tomorrow—what your rights are, what to do if you get arrested, and how to keep yourself safe.
Please repost far and wide…

#BoostTheBefriendmentForThe25thAmendment

open.substack.com/pub/psychope...

Microflyering resource page for science activists — STAND UP FOR SCIENCE

If you’re headed out to protest today, @standupforscience.bsky.social has EXCELLENT microflyers for you to print and share! (Also, check out our new website!)

www.standupforscience.net/microflyering

YouTube video by Danish BioImaging - DBI Meet the DBI Users - Interview with Andrea Mancini - Danish Cancer Institute - Phd Student

🔴Meet the DBI Users
Andrea Mancini, PhD researcher at the Danish Cancer Institute, is working on a research project that uses the Carl Zeiss Cell Discoverer 7 microscope for automated high-throughput microscopy. Watch the video
www.youtube.com/watch?v=59dH...

More info:
www.dbi-infra.eu/videos

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer - Nature Genetics This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer www.nature.com/articles/s41... #SpatialMedicine #PrecisionMedicine #LungCancer @lungfoundation.bsky.social @iaslc.bsky.social

Induction of menstruation in mice reveals the regulation of menstrual shedding During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Organelle fitness ➡️ cell fitness
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x

@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...

Dynamic control of autoreactive B cells from spontaneous germinal centers Abstract. Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled

'The mechanisms controlling the inclusion of new B cell clones into spontaneous germinal centers (GCs) remain unclear. Using CRISPR-Cas9, we generated 2 autoreactive B cell receptor knock-in strains, M05 and G55, based on B cell receptors from WT GC B cells in WT:564Igi chimeras'

Scientist on three-week off-grid hike finds out he's won the Nobel prize Dr Fred Ramsdell was "living his best life" offline when the Nobel committee tried to contact him.

Dr Ramsdell, whose phone had been on airplane mode, told the BBC's Newshour Programme that his first response when his wife said, "You've won the Nobel prize" was: "I did not."

To which Ms O'Neill replied that she had 200 text messages that suggested he had.

www.bbc.com/news/article...

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

This year’s Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a class of immune cells that help to prevent the body from attacking its own tissues. #medsky 🧪

Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.

This was a collaboration between Julie Cheung and Brian Hunt
in the lab

Thanks to Cancer Cell for publishing our work.

www.cell.com/cancer-cell/...

UMass Amherst Microbiology is hiring a tenure-track virologist. Come work with me! 🦠🧪
careers.umass.edu/amherst/en-u...

Sketches of six stages of cytokinetic development of the intercellular bridge are illustrated with exmaple U-ExM fluorescence microscopy images. Septin2-GFP shown in green. Tubulin shown in magenta. A shortened workflow illustrates the image alignment and averaging process to generate average 2D reconstructions of cytokinetic stages.

It is out! 🦚 I recorded hundreds of #ExM 🔬images of cytokinetic bridges and averaged them into 6 stages. How? With help from our fantastic collaborators @zacsimile.bsky.social and @jonasries.bsky.social in Vienna 😇. Check out the full atlas here: doi.org/10.5281/zenodo.17232370

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

The mini placentas and ovaries revealing the basics of women’s health Lab-made organoids that mimic reproductive tissues could point to treatments for common conditions such as pre-eclampsia and endometriosis.

Organoids are more realistic than 2D cell cultures, and can be more representative than animal models

go.nature.com/3VvJOcc