Loyal Goff

Congrats!

America's retreat from research risks exodus of world's 'brightest minds' Johns Hopkins neuroscientist Uli Mueller came to the U.S. from Germany decades ago because of the unrivaled opportunities for research and discovery. He worries that cuts to research funding will upen...

hub.jhu.edu/2025/05/21/u...

Congratulations Debby! Such a cool finding and a great story.

Science Magazine cover 28 Feb 2025; "An oval squid (Sepioteuthis lessoniana)"

With more mollusk genomes available, a new genome-based phylogeny is featured on the cover of Science. Paper from @sigwartae.bsky.social at www.science.org/doi/10.1126/... Cover photo by Magnus Lundgren.

Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito The female mosquito's remarkable ability to hunt humans and transmit pathogens relies on her unique biology. Here, we present the Mosquito Cell Atlas (MCA), a comprehensive single-nucleus RNA sequenci...

A mosquito cell atlas www.biorxiv.org/content/10.1... ht @leslievosshall.bsky.social

RNA xkcd.com/3056

'Trans-differentiation of neutrophils from plasmablast' is an artefact caused by over-reliance on machine algorithms in single cell RNA sequencing analysis: Lesson learnt and steps ahead https://www.biorxiv.org/content/10.1101/2025.02.07.636761v1

Just saw this. NIH is capping indirects at 15%. This will crush so many institutions. grants.nih.gov/grants/guide...

70% of scientists say they experience the imposter syndrome. I still experience it too sometimes, and what helps is talking with a science buddy with whom it’s ok to say stupid things, which may actually turn out to be good ideas.

New method for identifying spatially variable genes in spatial transcriptomics.

We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.

with @PhillipNicol et al.

www.biorxiv.org/content/10.1...

Decoding disease: Novel tool helps identify mutations in mitochondrial DNA Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of se...

Nice work from Nicole Lake and Monkol Lek (with a small contribution from our group):
medicalxpress.com/news/2024-11...

Thanks for compiling. Please count me in as well!

You already want to block me? :)