W H T

Nope. Only showing increased incidence. No diagnostic or treatment specifics are provided in this paper. Outside commentary by specialists state that the increased incidence is associated with decreased presence of NK cells, and other immune system suppressors.

Yes, I suppose, as long as the peeps are unlucky and are damaged. Most importantly, the goal would be to bump up immunity so that the next one might not kill so many compromised bodies. Always prepare.

Hypothetical Impact of Universal Vitamin D Optimization on Global COVID-19 Pandemic Outcomes. Background COVID-19 Pandemic. Vitamin D3 supplementation was not recommended by the US Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH) COVID-19 Treatment Guidelines Panel, or other major pandemic leadership bodies (e.g., WHO) specifically for the prevention or treatment of COVID-19. These organizations consistently emphasized that there was insufficient evidence from randomized controlled trials (RCTs) to support its use for this purpose, despite observational data suggesting associations between low vitamin D levels and worse outcomes. Instead, they advised against routine supplementation beyond general health guidelines for those with confirmed deficiencies, and warned that it should not replace proven measures like vaccination or masking. Why the Caution? Officials prioritized evidence-based measures to avoid false hope or resource diversion, especially amid misinformation about unproven supplements. The result? Potentially millions of lives lost to COVID-19. Abstract This report evaluates the hypothetical impact of optimizing vitamin D levels (serum 25-hydroxyvitamin D [25(OH)D] >30–50 ng/mL) with concurrent vitamin K2 supplementation across the global population prior to the COVID-19 pandemic (pre-2019) on mortality and disease severity. Observational studies and meta-analyses link vitamin D insufficiency (<30 ng/mL) to increased risks of severe SARS-CoV-2 outcomes, including hospitalization, intensive care unit (ICU) admission, and death. Population attributable risk (PAR) models and adjusted odds ratios (ORs) suggest that universal vitamin D optimization, paired with K2, could have reduced global mortality by 20–70% and severe cases by 30–80%. These findings highlight the potential of combined vitamin D and K2 supplementation in pandemic preparedness. PAGE 1 of 4

Results Global Vitamin D Status Pre-Pandemic Pre-2019, vitamin D insufficiency (<30 ng/mL) affected 30–60% of global populations, with deficiency (<20 ng/mL) in 10–40%, varying by region, age, and ethnicity [5,6]. Higher rates were observed in the US (~40%), Europe (50–70% in northern latitudes), and Asia (e.g., 60% in India) [9,10]. Elderly and obese groups showed 50–80% deficiency [11]. Vitamin D and COVID-19 Outcomes Studies consistently link low 25(OH)D levels to worse COVID-19 outcomes: • A 2025 meta-analysis (n=351 studies) reported 38–60% lower risk of severe outcomes (hospitalization, ICU) with sufficient vitamin D (>30 ng/mL), with mortality ORs of 1.5–2.7 for deficient vs. sufficient groups [12]. • A 2020 study (n=185, Heidelberg) found an 11.3-fold higher mortality risk in insufficient patients (<20 ng/mL), with 87% of deaths attributable to insufficiency [13]. • A 2021 meta-analysis predicted near-zero excess mortality at 25(OH)D ≥50 ng/mL [14]. • A 2024 RCT (n=86) showed high-dose supplementation (60,000 IU/day) achieving >50 ng/mL reduced viral load and inflammation [15]. • European data (2020) showed a correlation (r=0.79) between vitamin D deficiency and COVID-19 mortality per million [16]. Hypothetical Impact on Global Pandemic Assuming universal optimization to >30–50 ng/mL with K2 (100–200 µg/day) pre-2019: • Mortality Reduction: PAR models suggest 20–90% of deaths attributable to vitamin D insufficiency [13,21]. With ~7 million global deaths [8], 1.4–6.3 million could have been averted (20–90%); conservative OR-based estimates (1.5–2.7) suggest 2–4 million fewer deaths (30–60%) [12,22]. • Severity Reduction: 50–80% lower odds of ICU admission/ventilation with sufficient vitamin D [12,23]. K2 ensures safety of high doses, potentially amplifying reductions by minimizing adverse effects [7,19]. PAGE 2 of 4

Hypothetical Impact on Global Pandemic (cont ...) • Mechanisms: Vitamin D enhances cathelicidin, reduces IL-6, and upregulates ACE2, mitigating ARDS [3,4]. K2 prevents vascular damage from hypercalcemia, supporting long-term supplementation [2,17]. • Comorbidity Interaction: Vitamin D insufficiency correlates with multimorbidity (OR 1.3–1.4) [24]. Pre-optimization with K2 could reduce comorbidity severity (e.g., cardiovascular, diabetes), lowering COVID-19 risk [25]. Limitations • Observational Bias: Vitamin D correlations may reflect poor health rather than causation [26]. • Confounders: Age, obesity, and socioeconomic factors complicate attribution [27]. • Limited RCTs: Small trials support benefits, but large-scale D3/K2 intervention data are absent [15]. • K2 Data Gaps: Few studies directly test D3/K2 in COVID-19; benefits are inferred from calcification prevention [18,19]. • Regional Variability: Deficiency prevalence varies, affecting impact estimates [9]. Discussion Universal vitamin D optimization to >30–50 ng/mL with K2 supplementation pre-2019 could have reduced COVID-19 mortality by 20–70% (1.4–4.9 million deaths) and severe cases by 30–80%, driven by immune modulation and inflammation control [3,4,12]. K2’s role in preventing hypercalcemia and calcification ensures safety of aggressive D3 dosing, critical for population-wide intervention [1,2,7]. Conservative estimates suggest 30–60% mortality reductions, with K2 enhancing feasibility by minimizing risks [19]. These findings align with vitamin D’s benefits in other respiratory infections [28]. Challenges include logistical scale-up and K2 dietary deficiency [20]. Future pandemics could leverage D3/K2 screening and supplementation, particularly for high-risk groups. Conclusion Optimizing global vitamin D levels before the COVID-19 pandemic could have reduced mortality by 20–70% and severe cases by 30–80%. These findings advocate for integrated D3/K2 strategies in public health preparedness.

References PAGE 4 of 4

WHAT IF? Optimizing global vitamin D levels with K2 supplementation before the COVID-19 pandemic could have reduced mortality by 20–70% and severe cases by 30–80%. These findings advocate for integrated D3/K2 strategies in public health preparedness.

Yes, most have read this highly publicized observation reported by MD Anderson Cancer Center. Very similar to the under reported effect of melatonin supplements. It is also under reported that mRNA tech is immature and that unprecedented profits generated thru mandates will fund future research.

You tell me. You are informed, right? Also provide data that proves your statements. I don't have time to educate you today. Maybe next weekend. In the mean time, I'll be looking forward to your list, with citations.

Time will tell.

Yes. Please ignore anyone with an opinion that differs from your own. Very healthy. Good luck.

People have not been given the truth. So, it is necessary that people collaborate to ensure enlightenment - at least with regard to the fantasies surrounding pandemic leadership dialogue. It was criminal. This may be why you seem confused. Why were so so many people - yes - duped? MONEY.

Do you promote the concept of retribution? Isn't that what it appears as though they are currently upto? Comey is in deep dip now for his purported role in Russia gate, right? So following your line of logic, it's ok that Trump's people are enforcing the law? Weird.

You are too extreme. Sharing of thought need not become abusive.

That's a lot of money.

Focus on pubmed or Google scholar for your sources.

You are not making sense.

Of course there is a need for more work. It should never end. As per usual, the more detail that you begin to understand, the more minutia you expose, i.e., prompting more questions

Corona virus is a common cold type virus, not flu. Not the platform to debate the origin of covid-19.

There are conventional treatments that effectively cure the infections. But, the mRNA technology could not meet regulatory thresholds, therefore emergency use status + blocked remedies. Sham.

Also keep in mind that the seasonal flu vaccine has missed its predicted target each year in its existence. Failed concept.

New analysis is showing that flu vaccine in year one will increase susceptibility to year two flu virus. It's nuts. They need better QA/QC

Probably due to a lack in data availability. It's difficult at best, but typically impossible to get your hands on vaccine data, esp in USA.

Covid is now endemic. Most people have been exposed. Natural antibodies abound. The COVID mRNA shot is becoming more of a burden than a benefit. Sad truth

Yes!. Keep it up and we will find ourselves directly in the middle of a civil war! Keep dividing! WhooHoo!

Of course I am being facetious. Please retire. You are in denial Nancy.

What a grand concept! Communication! Who thought of this modis, genius!

Don't go extreme, useless argument. The inventor of mRNA tech is urging caution, recommending significant refinement before further release to the general public.

It turns out that various "adjuvants" of conventional vaccines should be removed to better preserve the health of our youth.

Work on the definition. You might best add "libtard preferred vocabulary" ... "wah, wah, wah, me, me, me, I want, I want, I want, ..."

Just an observation. Sorry that you hate so many people. Must be difficult.

Now yes. I would buy one of these with Obama pasted on the back. Great t shirt plan.

Are we still concerned about Joe's well-being? Let's just move on.

At least we now have an elected leader that can talk and interact - like him or not. The key may be to acknowledge that our opinions are the property and brainchild of someone else.

Yes, well established for peeps with highly compromised immune systems. Cleaning up diet, returning to a regular exercise regime smells
like a better long game. Too many negatives for healthy bodies - why bother ... but wait, let's feed big pharmas record profits. Let's make more billionaires. Yay!

Covariate, in this case a classification variable. Yes. Too bad the US doesn't have an archive like this ... for public use - minus PPI

Yes, they were included ... Check Supplement 2. This parameter was included as a covariate in the statistical model.

2. The synthetic nano particles spread throughout the body. The GMO spikes form uncontrollably - above appropriate dosing levels. This is a problem for some patients, commonly promoting excessive clotting, etc.

Purity was a problem with earlier batches, where DNA contaminants from E Coli were not sufficiently flushed. Read up. It's complicated.

Read to paper. Here's an excerpt:

"clinicians should prioritize monitoring the risk of gastric cancer in relation to COVID-19 booster doses."

Pun