Adrien Lemaignen

Current Epidemiology and Infection Characteristics of Non-Aspergillus Mold Infections: A Multicenter Study in Australia and New Zealand

✅ Just Accepted
🔗 https://bit.ly/4bLllbS

Rapidly Expanded EBV-Specific T Cells for the Treatment of Refractory EBV Reactivation and EBV-Related Lymphoproliferative Disorders

✅ Just Accepted
🔗 https://bit.ly/4pVZkuB

Figure showing diagnostic and therapeutic algorithm of leprosy. Copyright: 2025 Elsevier Ltd. All rights are reserved.

Leprosy, or Hansen's disease, remains a key global health issue.

In a new Seminar, authors provide an update on key public health and clinical aspects of the disease: spkl.io/63321AUcQ7

Longitudinal changes in cognition and brain imaging in persons with HIV

✅ Just Accepted
🔗 https://bit.ly/3NC68A4

New research article

Antimicrobial resistance in bacterial #meningitis caused by #Streptococcus pneumoniae, #Neisseria meningitidis, or #Haemophilus influenzae (2010–24): a systematic review and meta-analysis

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #AMR #OpenAccess #OA

Thanks!

Triazoles versus Echinocandins for the first-line treatment of invasive pulmonary aspergillosis ? A propensity score weighted multicenter study

✅ Just Accepted
🔗 https://bit.ly/3LV7LYP

Characteristics of tuberculosis in elderly adults: A multicenter French study The incidence of tuberculosis (TB) remains high in elderly adults in France. Immunosenescence and comorbidities challenge both diagnosis and treatment…

[Publication] The article "Characteristics of tuberculosis in elderly adults: A multicenter French study" is now available.

www.sciencedirect.com/science/arti...

#IDsky #Tuberculosis #ElderlyAdults #AtypicalPresentation #GeriatricInfectiousDisease #Mortality

Seasonal influenza and pneumococcal vaccination coverage among immunocompromised adults in France: A need for improvement To estimate influenza and pneumococcal vaccination coverage in immunocompromised adults in France.We used the Echantillon Généraliste des Bénéficiaire…

[Publication] The article "Seasonal influenza and pneumococcal vaccination coverage among immunocompromised adults in France: A need for improvement" is now available.

www.sciencedirect.com/science/arti...

#IDsky #Immunocompromised #Vaccines #StreptococcusPneumoniae #Influenza #France

The New England Journal of Medicine A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia A Research Summary based on Lucinde RK et al. | 10.1056/NEJMoa2507100 | Published on October 29, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In the SONIA trial conducted in general medical wards with limited diagnostic and therapeutic resources in Kenya, glucocorticoids reduced mortality in patients with community-acquired pneumonia. Full trial results and Research Summary: nej.md/47glh02

#MedSky #PulmSky #IDSky

Diagnostic Efficacy and Clinical Impact of Image-guided Core Needle Biopsy of Suspected Adult Non-Vertebral Osteomyelitis

✅ Just Accepted
🔗 https://bit.ly/4oYHCGS

P2Y12 inhibitors in Staphylococcus aureus bacteraemia: current evidence and clinical implications Staphylococcus aureus bacteraemia presents a substantial clinical burden, with high rates of morbidity and mortality. Despite its severity, therapeutic advancements have been small in the past decade,...

🆕🌟Excellent review article
P2Y12 inhibitors(eg clopidogrel,ticagrelor)in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Coming soon: CLOPI-SNAP+ Clopido-SNAP #idsky #EMIMCC
www.thelancet.com/journals/lan...

Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial) AbstractBackground. Delayed pulmonary tuberculosis (TB) diagnosis, especially with limited bronchoscopy resources, worsens outcomes and increases transmiss

Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial)

✅ Just Accepted
#IDSky

Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study Peripherally inserted central catheters (PICCs) are associated with complications including deep vein thrombosis (DVT) and infections. However, the ri…

[Publication] The article "Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study" is now available.

www.sciencedirect.com/science/arti...

#IDsky #PeripherallyInsertedCentralCatheter #DeepVeinThrombosis #RiskFactors #S.Aureus

Napoleon's retreat from Moscow CREDIT Barbieri et al., Current Biology

DNA from Napoleon’s 1812 army identifies the pathogens likely responsible for the army’s demise during their Russian retreat. www.cell.com/current-biol...

Nicolás Rascovan & colleagues
@currentbiology.bsky.social

Syphilis Pathogenesis: Host Immune Response vs Pathogen Immune Evasion Syphilis, caused by Treponema pallidum subspecies pallidum, remains a significant global health problem despite being preventable and curable.

Syphilis Pathogenesis: Host Immune Response vs Pathogen Immune Evasion

#IDSky

This monocentric observational study of 137 patients with bone & joint infection treated by clindamycin of which 88 received monotherapy shows in univariate, multivariate & IPTW analysis a reliable & safe use of monotherapy in those infections:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

🆕🔥🔥CloCeBa RCT
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...

New review article

Role of gut #microbiota disruption in prosthetic joint infection: a scoping review

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #PJI #OpenAccess #OA

🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...

Rapid diagnostic tests combined with individualised decision-making improve the selection of antibiotic therapy. Rapid de-escalation to narrow-spectrum monotherapy and shortening of the duration of therapy should be the rule. #IDsky #EMIMCC

Efficacy and Safety of Dual Therapy With Dolutegravir/Lamivudine in Treatment-naive Persons With CD4 Counts <200/mm3: 48-Week Results of the DOLCE Study Treatment-naive people with human immunodeficiency virus with very low CD4 counts and high viral load are a difficult-to-treat population. DOLCE explored t

In CID, Maria Ines Figueroa and colleagues evaluated the antiviral activity of dolutegravir/lamivudine among antiretroviral therapy (ART)-naive patients with HIV with a CD4 count ≤200 cells/mm³. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf415/8241230

This retrospective cohort from 🇫🇷showed that oral switch is a suitable option for treating IE, even for POET-ineligible patients

➡️treatment failure HR=0.55 favoring oral, 95%CI 0.27-1.17
➡️more days alive outside 🏥 in oral group (59 vs 47, p=0.001)

doi.org/10.1093/cid/...

#IDSky

West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures

[Publication] The article "West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures" is now available.

www.sciencedirect.com/science/arti...

#IDsky #WestNileVirus #PublicHealthSurveillance #VectorBorneDiseases #OneHealthApproachItaly

The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp. Oritavancin is emerging as a potential alternative to standard antibiotic regimens in the treatment of infective endocarditis caused by gram-positive bacteria, though evidence remains limited.

The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp.

✅ Just Accepted
#IDSky

State-of-the-Art Review: Anal Cancer Screening in People With HIV New data and clinical guidelines support anal cancer screening of people with HIV, but important questions related to overall effectiveness, harms, and equitable deployment must be considered when implementing them.

State-of-the-Art Review: Anal Cancer Screening in People With HIV

#IDSky
academic.oup.com/cid/article/...

Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials The role of adjunctive fosfomycin in Staphylococcus aureus bacteremia (SAB) remains uncertain.

Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials

✅ Just Accepted
#IDSky

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital Central nervous system (CNS) infections are significant causes of morbidity and mortality, especially when diagnosis is delayed.

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital

✅ Just Accepted
#IDSky

SNAP trial update

➡️ The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.

#IDsky

Screenshot of title and authors for 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People

@jobadd.bsky.social @joshuawolf.bsky.social et al

doi.org/10.1093/cid/...