Adrien Lemaignen

P2Y12 inhibitors in Staphylococcus aureus bacteraemia: current evidence and clinical implications Staphylococcus aureus bacteraemia presents a substantial clinical burden, with high rates of morbidity and mortality. Despite its severity, therapeutic advancements have been small in the past decade,...

🆕🌟Excellent review article
P2Y12 inhibitors(eg clopidogrel,ticagrelor)in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Coming soon: CLOPI-SNAP+ Clopido-SNAP #idsky #EMIMCC
www.thelancet.com/journals/lan...

Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial) AbstractBackground. Delayed pulmonary tuberculosis (TB) diagnosis, especially with limited bronchoscopy resources, worsens outcomes and increases transmiss

Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial)

✅ Just Accepted
#IDSky

Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study Peripherally inserted central catheters (PICCs) are associated with complications including deep vein thrombosis (DVT) and infections. However, the ri…

[Publication] The article "Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study" is now available.

www.sciencedirect.com/science/arti...

#IDsky #PeripherallyInsertedCentralCatheter #DeepVeinThrombosis #RiskFactors #S.Aureus

Napoleon's retreat from Moscow CREDIT Barbieri et al., Current Biology

DNA from Napoleon’s 1812 army identifies the pathogens likely responsible for the army’s demise during their Russian retreat. www.cell.com/current-biol...

Nicolás Rascovan & colleagues
@currentbiology.bsky.social

Syphilis Pathogenesis: Host Immune Response vs Pathogen Immune Evasion Syphilis, caused by Treponema pallidum subspecies pallidum, remains a significant global health problem despite being preventable and curable.

Syphilis Pathogenesis: Host Immune Response vs Pathogen Immune Evasion

#IDSky

This monocentric observational study of 137 patients with bone & joint infection treated by clindamycin of which 88 received monotherapy shows in univariate, multivariate & IPTW analysis a reliable & safe use of monotherapy in those infections:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

🆕🔥🔥CloCeBa RCT
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...

New review article

Role of gut #microbiota disruption in prosthetic joint infection: a scoping review

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #PJI #OpenAccess #OA

🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...

Rapid diagnostic tests combined with individualised decision-making improve the selection of antibiotic therapy. Rapid de-escalation to narrow-spectrum monotherapy and shortening of the duration of therapy should be the rule. #IDsky #EMIMCC

Efficacy and Safety of Dual Therapy With Dolutegravir/Lamivudine in Treatment-naive Persons With CD4 Counts <200/mm3: 48-Week Results of the DOLCE Study Treatment-naive people with human immunodeficiency virus with very low CD4 counts and high viral load are a difficult-to-treat population. DOLCE explored t

In CID, Maria Ines Figueroa and colleagues evaluated the antiviral activity of dolutegravir/lamivudine among antiretroviral therapy (ART)-naive patients with HIV with a CD4 count ≤200 cells/mm³. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf415/8241230

This retrospective cohort from 🇫🇷showed that oral switch is a suitable option for treating IE, even for POET-ineligible patients

➡️treatment failure HR=0.55 favoring oral, 95%CI 0.27-1.17
➡️more days alive outside 🏥 in oral group (59 vs 47, p=0.001)

doi.org/10.1093/cid/...

#IDSky

West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures

[Publication] The article "West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures" is now available.

www.sciencedirect.com/science/arti...

#IDsky #WestNileVirus #PublicHealthSurveillance #VectorBorneDiseases #OneHealthApproachItaly

The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp. Oritavancin is emerging as a potential alternative to standard antibiotic regimens in the treatment of infective endocarditis caused by gram-positive bacteria, though evidence remains limited.

The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp.

✅ Just Accepted
#IDSky

State-of-the-Art Review: Anal Cancer Screening in People With HIV New data and clinical guidelines support anal cancer screening of people with HIV, but important questions related to overall effectiveness, harms, and equitable deployment must be considered when implementing them.

State-of-the-Art Review: Anal Cancer Screening in People With HIV

#IDSky
academic.oup.com/cid/article/...

Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials The role of adjunctive fosfomycin in Staphylococcus aureus bacteremia (SAB) remains uncertain.

Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials

✅ Just Accepted
#IDSky

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital Central nervous system (CNS) infections are significant causes of morbidity and mortality, especially when diagnosis is delayed.

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital

✅ Just Accepted
#IDSky

SNAP trial update

➡️ The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.

#IDsky

Screenshot of title and authors for 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People

@jobadd.bsky.social @joshuawolf.bsky.social et al

doi.org/10.1093/cid/...

Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes: How Much Does Getting It Right With Empiric Antibiotics Matter?

Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes: How Much Does Getting It Right With Empiric Antibiotics Matter?

July 2025 Issue is now online: www.clinicalmicrobiologyandinfection.com/issue/S1198-...

What is the impact of anti-enterococcal empirical therapy on survival of patients with enterococcal bloodstream infections? The impact of early administration of active anti-enterococcal empirical therapy (EET) on outcomes of patients with enterococcal bloodstream infections (EBSI) is unclear.

What is the impact of anti-enterococcal empirical therapy on survival of patients with enterococcal bloodstream infections?

✅ Just Accepted
⭐ Editor's Choice
#IDSky

📢 New @ecdc.europa.eu guidelines: "Public health guidance for assessing and mitigating the risk of locally-acquired #Aedes-borne #viral diseases (eg. #dengue, #chikungunya #WestNile virus and #Zika) in the #EU 🇪🇺/EEA"
🦟 #arbovirus

www.ecdc.europa.eu/en/publicati...

Réforme du 3e cycle et DES de Maladies Infectieuses et Tropicales : quel bilan? Une enquête transversale nationale. La réforme du 3e cycle des études médicales effective depuis 2017 a permis la création d’un nouveau diplôme d’études spécialisées (DES) en Maladies In…

[Publication] L'article "Réforme du 3e cycle et DES de Maladies Infectieuses et Tropicales : quel bilan? Une enquête transversale nationale" est disponible dès aujourd'hui.

www.sciencedirect.com/science/arti...

#IDskyFR #MaladiesInfectieuses #FormationMédicale #DocteurJunior #QualitéDeVie

Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, plac... At all doses tested, emodepside was efficacious and well tolerated in individuals infected with S stercoralis. The broad-spectrum weight-independent dose and robust safety profile positions emodepside...

New Article:

Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial

www.thelancet.com/journals/lan...

Breakthrough atypical mpox in a vaccinated individual with high antibody titres A 56-year-old man attended a sexual health clinic for asymptomatic rectal Chlamydia trachomatis treatment. Patient history included treated syphilis, and he was taking tenofovir disoproxil fumarate–em...

Anyone have access to the Lancet: Infectious Diseases?

Public reports on this are saying he was infected despite “high antibody levels”, and I’d really like to know what they mean by that. 🧪

New research article

Centrifuge-free stool processing methods for Xpert MTB/RIF Ultra #tuberculosis diagnosis in children in Uganda and Zambia: an observational, prospective, diagnostic accuracy study

www.thelancet.com/journals/lan...

#IDSky #ClinMIcro #MicroSky #TBSky #TB #OpenAccess #OA

Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study Olorofim showed efficacy and good tolerability in patients with IFD with few or no treatment options. Further studies will be needed to fully delineate the role of this new antifungal agent.

New research:

Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study

www.thelancet.com/journals/lan...

Immunotherapy for Infectious Diseases: Back to the Future

Immunotherapy for Infectious Diseases: Back to the Future

✅ Just Accepted
#IDSky

This wonderful population-based study confirms that drainage of brain abscesses is associated with decreased mortality. Well done to the Aalborg ID team! #ORAL