Julia Meltzer

Figure comparing runtime and VRAM utilization between Boltz-2 (baseline), and LMI4Boltz (+memory, and +chunk). Main plot: runtime (y-axis) versus token count (x-axis), showing that all methods scale similarly, with +memory and +chunk handling larger token counts. Inset scatterplot: PDB test lDDT scores from Boltz-2 versus LMI4Boltz, showing a strong linear correlation (values near y = x). Right panels: – Top bar chart: maximum tokens processable on a 24 GB GPU increase from 1596 (Boltz-2) to 2356 (+memory) and 2660 (+chunk). – Bottom bar chart: H200 runtime for 1596 tokens remains comparable across methods.

🧶🧬 We present LMi4Boltz:
www.biorxiv.org/content/10.1...

Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.

LMI4Boltz: Optimizing VRAM utilization to predict large macromolecular complexes with consumer grade hardware AlphaFold2 has revolutionized structural biology by enabling the prediction of protein structures approaching experimental quality. AlphaFold3 extends this framework to support modelling broad biomole...

This is amazing work lead by Tom (@tlitfin.bsky.social) in my team. Always trying to get more for less and making computing efficient. So satisfying making science resources go further. Boltz2 is great for protein structure prediction and hopefully LMI4Boltz extends its use. Code on GitHub… 🧶🧬

An Asgard archaeon from a modern analog of ancient microbial mats It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...

This was fun! Folding whole proteomes… looking at tomogram, looking at genomes🤩 lots to discover!🧬🧶

So excited to finally show the world a project years in the making. A huge group effort with lots of expertise leading to a unique #Asgard syntrophy story. Very fortunate to have been involved in cultivating and analysing this wonderful organism ❤️

An Asgard archaeon from a modern analog of ancient microbial mats It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...

Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc

Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...

Our Big Fantastic Virus Database (BFVD) is now published NAR! It contains protein structure predictions of major viral clades, enhanced by petabase-scale homology search and it's explorable on the web.
🌐 bfvd.foldseek.com
💾 bfvd.steineggerlab.workers.dev
📄 academic.oup.com/nar/advance-...

Go @hannjbrown.bsky.social and @iduggin.bsky.social !! Archaea champs 💪🏽

@xabivc.bsky.social

. @snobsi.bsky.social @juliameltzer.bsky.social

ArchaeaCast Science Podcast · 3 Episodes · Updated Biweekly

New podcast entirely about archaea just started!

podcasts.apple.com/us/podcast/a...

Join us at the JAMS Sydney community! 🫶🏻♥️

Hi there! Just made it to 🦋 Would love to be added too!

Finally started migrating from X to bsky and hoping to connect with more people interested in #Bioinformatics 🧬💻. Thanks @amanzanom.bsky.social for all the tips so far and if someone out there have any good tips, please let me know!

A nice paper on microbial dark matter revealing that in situ devices increase coral's microbes culturability up to 570% is out on iScience 🧪. This device, initially used in soils, has proved to be useful in marine sponges and, now, in corals as well.
www.sciencedirect.com/science/arti...
#SymbioSky

Hello Blueskis. Here is a starter pack of General Microbiology. It's a small list currently. Please feel free to self-nominate and I will add you.

go.bsky.app/QgSQHJ9

I made a quick Starter Pack for scientists working on virus discovery - please reply if you’d like me to add you to the pack (or remove you) or to recommend anyone! #scisky go.bsky.app/HK1wxRb

I made a starter pack for researchers who study various aspects of viral sociality. It's woefully incomplete and has lots of room to grow, so do message me if I've missed you!

go.bsky.app/3PfgjkP

#SocialViruses 🦠 🧪

added to Virology and Virus-Host interaction #2 go.bsky.app/6bSDmrW