Antonin Nourisson

#DNApolymerase #PolX #GenomeDynamics #Paramecium #Ciliates #DNArepair #GenomeRearrangements #MolecularEvolution #OpenAccess #Science
@narjournal.bsky.social @sorbonne-universite.fr @ipdbsc.bsky.social @pasteur.fr

🌍 Beyond Paramecium, our study sheds light on how DNA polymerases evolve new functions. This helps us understand both the flexibility and limits of DNA repair machineries across life.

⚡ Key finding: PolX enzymes in Paramecium are specialized & diversified. They show striking trade-offs between accuracy and adaptation to unusual DNA substrates, reflecting evolutionary fine-tuning.

🧬 We explored their fidelity and specialization:

How accurately do they replicate DNA?

Do different PolX enzymes have distinct functions?

How did they evolve to meet Paramecium’s unique genomic needs?

🔬 Our work focuses on Paramecium’s PolX DNA polymerases, unusual enzymes that play key roles in programmed genome rearrangements. These processes are essential for the development of the somatic genome in ciliates.

Fidelity, specialization, and evolution of Paramecium PolX DNA polymerases involved in programmed double-strand break DNA repair Abstract. Repairing programmed DNA double-strand breaks (DSBs) is crucial in the lifecycle of Paramecium tetraurelia, especially during its sexual reproduc

🎉 Thrilled to share that my PhD work is now published in Nucleic Acids Research! Huge thanks to my colleagues and mentors who made this journey possible 🙌
👉 doi.org/10.1093/nar/...

Supprimer les sciences sociales du CNRS alors qu'il nous faut affronter les crises démocratiques, sociales et environnementales ?
NON
#StandUpFOrScience défend toutes les sciences et leur collaboration. Comment imaginer éclairer les enjeux actuels sans les sciences sociales ? #SolidaritéST-SHS

#StandUpForScience
Voici une partie des mots listés comme à bannir, éviter ou couper par l'administration Trump. Au moins 5000 pages d'agences fédérales affectées d'après @nytimes.com. Cette liste sert aussi à censurer des initiatives, bourses ou projets de recherche.

Archaeal Virology Unit @pasteur.fr stands up for science!

@vsevillia.bsky.social, Titouan, @miguelgrv.bsky.social, Eduardo, @anton1nouriss.bsky.social, ..., Virginija, @sonaida.bsky.social, Jovan

De l'art de la titraille dans les articles de #biologie
Le long format : une narration exigeante et respectueuse des lecteurs. Avec ici, l'humour en plus :)
Jugez plutôt !
👇👇👇
Ces titres improbables de publications scientifiques en biologie
www.lemonde.fr/blog/realite...

Sheaths are diverse and abundant cell surface layers in archaea Abstract. Prokaryotic cells employ multiple protective layers crucial for defense, structural integrity, and cellular interactions in the environment. Arch

Have you ever heard about sheaths? Happy to share our last paper with @sgribaldo.bsky.social and Guillaume Borrel @pasteur.fr where we investigated their distribution and evolution!
doi.org/10.1093/isme...
Below a thread of our major findings:

Since I just arrived here, it's a good occasion to share my first first author article (here in preprint). It summarizes all my work during my PhD to understand the high fidelity of a specialized NHEJ in Paramecium.
🧬👨🏼‍🔬💎