Michal Kacper Bialobrzewski

The GBM Compact - Focus on Condensate Biology poster session has 5 winners: Miriam Linsenmeier (FEBS Open Bio award), Patrick McCall and Michal Kacper Bialobrzewski (sponsored by De Gruyter Brill). Two book vouchers from Wiley were awarded to Saskia Hutten and Nora Haanaes! Congratulations!

Screencap from the homepage showing various structural similarity metrics between a pose and a reference structure

A single python package for calculation of quality metrics like DockQ, LDDT, RMSD, & others

peppr.vant.ai

Accurate prediction of thermoresponsive phase behavior of disordered proteins Protein responses to environmental stress, particularly temperature fluctuations, have long been a subject of investigation, with a focus on how proteins maintain homeostasis and exhibit thermoresponsive properties. While UCST-type (upper critical solution temperature) phase behavior has been studied extensively and can now be predicted reliably using computational models, LCST-type (lower critical solution temperature) phase transitions remain less explored, with a lack of computational models capable of accurate prediction. This gap limits our ability to probe fully how proteins undergo phase transitions in response to temperature changes. Here, we introduce Mpipi-T, a residue-level coarse-grained model designed to predict LCST-type phase behavior of proteins. Parametrized using both atomistic simulations and experimental data, Mpipi-T accounts for entropically driven protein phase separation that occurs upon heating. Accordingly, Mpipi-T predicts temperature-driven protein behavior quantitatively in both single- and multi-chain systems. Beyond its predictive capabilities, we demonstrate that Mpipi-T provides a framework for uncovering the molecular mechanisms underlying heat stress responses, offering new insights into how proteins sense and adapt to thermal changes in biological systems. ### Competing Interest Statement The authors have declared no competing interest.

Our work helps bridge the gap between fundamental biophysics and real-world applications. Want to learn more? Read @jerelleaj.bsky.social and my new preprint on BioRXiv! biorxiv.org/content/10.1... 📖 (4/4)

This is a massive public health and educational crisis, and we (scientists and journalist) need to help people make sense of it. Rapidly. Get your frames together people. Start sharing them in any way you can.

🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍

I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.

Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...

1/ 🚨We’re thrilled to share our latest study:

"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟

www.biorxiv.org/content/10.1...

How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️

The structural basis for RNA slicing by human Argonaute2 Mohamed et al. report the cryoelectron microscopy structure of human AGO2 with fully paired guide RNA. Their analysis reveals the structural basis for the slicing activity that drives RNAi, showing that the slicing-competent conformation is achieved by domain movements and RNA-protein contacts distinct from those of conformational intermediates and prokaryotic homologs.

Our collaborative AGO2 work with @bartellab.bsky.social is published! Abdallah and Peter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing

Kartvelo,Kheli Khmals Ikar 💪

Excited to announce the release of our preprint, "The Martini 3 Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior", now available on @chemrxiv.bsky.social

👉 Read the full preprint here: chemrxiv.org/engage/chemr...

Debunked dogma: disordered proteins disregard ligands’ chirality Understanding unfolded proteins could boost drug discovery and decipher origins of life mysteries

Debunked dogma: disordered proteins disregard ligands’ chirality 🧬 my latest story for @chemistryworld.bsky.social on a fantastic and surprising Nature paper by Johan Olsen and Birthe Kragelund teams 🇩🇰 Read more below! #realtimechem #chemsky 🧪 www.chemistryworld.com/news/debunke...

AlphaFold3 still tends to overfit regions that AF2 multimer predicts to be disordered. Almost all disordered regions become helices in AF3.

Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...

Congratulations @guyteichman.bsky.social et al!!