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Elisa Fadda

@elisafadda.bsky.social

Associate Professor in the School of Biological Sciences at the University of Southampton, head chef at https://GlycoShape.org, Salem's butler, fucose fanatic #glycotime everyday! She/Her

2,404 Followers  |  1,504 Following  |  1,260 Posts  |  Joined: 12.11.2024  |  1.8819

Latest posts by elisafadda.bsky.social on Bluesky

That's such a lovely memory. May all your #ChemNobel predictions ring true to soften the day 😊 but I am sure Prof Stoddard really admired Car and Parrinello 😁

08.10.2025 06:53 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Fraser lived his life at a hundred miles an hour. But it wasn't always the best thing for him or for those closest to him. In an interview following the award of the Nobel Prize in 2016 he recalled his time growing up on a farm and said that that had instilled in him the work ethic of a honeybee. Nobody would doubt that he had that. He also talked about having the strength of a horse and the hide of an elephant; what he didn't mention is that he could also be as stubborn as a mule. He did things his way and was rarely persuaded to do otherwise.

This bloody-mindedness undoubtedly contributed to his incredibly successful career. While those who didn't really know him will measure his contributions through the prizes he won, his real professional legacy is not those prizes, it is the people who passed through his lab and shared in his scientific journey. Yes, he changed science, but he changed lives too - including mine and many of those here today. I learned a lot from Fraser: some chemistry, how to make slides for presentations, how to always include a noun after the word 'this', and a few random Scottish words that I'm still not convinced he didn't just make up.

A screenshot of text that reads: Fraser lived his life at a hundred miles an hour. But it wasn't always the best thing for him or for those closest to him. In an interview following the award of the Nobel Prize in 2016 he recalled his time growing up on a farm and said that that had instilled in him the work ethic of a honeybee. Nobody would doubt that he had that. He also talked about having the strength of a horse and the hide of an elephant; what he didn't mention is that he could also be as stubborn as a mule. He did things his way and was rarely persuaded to do otherwise. This bloody-mindedness undoubtedly contributed to his incredibly successful career. While those who didn't really know him will measure his contributions through the prizes he won, his real professional legacy is not those prizes, it is the people who passed through his lab and shared in his scientific journey. Yes, he changed science, but he changed lives too - including mine and many of those here today. I learned a lot from Fraser: some chemistry, how to make slides for presentations, how to always include a noun after the word 'this', and a few random Scottish words that I'm still not convinced he didn't just make up.

It’s #chemnobel day. For me, and for quite a few other people who spent time in the Stoddart group, it will hit somewhat differently this year.

Seems the right time to share a couple of passages from the eulogy I gave at Fraser’s funeral earlier this year.

08.10.2025 06:46 β€” πŸ‘ 24    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

The proteasome-substrate-shuttle protein UBQLN2 containsβ€”like other quality control system proteinsβ€”a long region devoid of lysine (a lysine desert)

Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation

doi.org/10.1101/2025...

07.10.2025 21:19 β€” πŸ‘ 27    πŸ” 9    πŸ’¬ 2    πŸ“Œ 1

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

1/14

06.10.2025 23:27 β€” πŸ‘ 283    πŸ” 153    πŸ’¬ 11    πŸ“Œ 22
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Chemistry with Cats From SchrΓΆdinger's Paradox to Quantum Computing

2/2 my personal favourite,

2) Anna Krylov and Jay Tanzman blog post about the pivotal contribution of cats to (quantum) chemistry:

hxstem.substack.com/p/chemistry-...

Happy reading! πŸ˜ΊπŸŽ‰ πŸ§ͺ

07.10.2025 19:12 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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The Chemistry of Cats | Reactions Science Videos - American Chemical Society A look at some of the key "meow-locules" that make up the chemistry of cats.

Tomorrow is #ChemNobel day!! πŸ₯³πŸ₯³ While we are all waiting eagerly for the announcement, my cat Salem suggest to you #chemsky friends some important reading to quench the nerves,

1) ACS important content: www.acs.org/pressroom/re...

And... 1/2 🧡

07.10.2025 19:10 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Calling Bullshit: Data Reasoning in a Digital World The world is awash in bullshit. Politicians are unconstrained by facts. Science is conducted by press release. Higher education rewards bullshit over analytic thought. Startup culture elevates bullshi...

Continuing my tour of books I should have already read, Calling Bullshit by @carlbergstrom.com and @jevinwest.bsky.social. Just a delight - an accessible, entertaining, insightful look at various forms of BS. Much like Weapons of Math Destruction, would love a 2025 update of this one.

07.10.2025 00:55 β€” πŸ‘ 363    πŸ” 70    πŸ’¬ 11    πŸ“Œ 6
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Nobel Prize in Physics 2025 The Nobel Prize in Physics 2025 was awarded to John Clarke, Michel H. Devoret and John M. Martinis "for the discovery of macroscopic quantum mechanical ...

The @natureportfolio.nature.com Collection celebrating the 2025 #NobelPrize in #Physics is now live!

07.10.2025 16:26 β€” πŸ‘ 9    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Congrats to all!! Brilliant πŸ‘πŸ»πŸ₯³πŸ₯³πŸ‘πŸ»πŸ‘πŸ»

07.10.2025 16:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Wow! This is magnificent #glycotime Anne! I thought only I could see hydrogen atoms!! πŸ˜‚πŸ˜‚πŸ₯³πŸ₯³

07.10.2025 16:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration

07.10.2025 14:07 β€” πŸ‘ 19    πŸ” 8    πŸ’¬ 2    πŸ“Œ 2
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This sounds plausible to me. But if it’s true, it means that the age of social media might be over soon, with only the old and wrinkled (like myself) spending any actual time there.

07.10.2025 06:59 β€” πŸ‘ 52    πŸ” 24    πŸ’¬ 6    πŸ“Œ 6

This is fabulous #glycotime!! 😍 Super congrats to you all! πŸ‘πŸ»πŸ‘πŸ»πŸ‘πŸ»

07.10.2025 07:07 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Check our new venture into drug discovery #glycotime!

07.10.2025 06:11 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Generative AI for computational chemistry: A roadmap to predicting emergent phenomena | PNAS The recent surge in generative AI has introduced exciting possibilities for computational chemistry. Generative AI methods have made significant pr...

www.pnas.org/doi/10.1073/...

06.10.2025 21:21 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Polar stereographic map of 2-m temperature trends in units of Β°C per decade over the Arctic for the month of October. Trends are calculated over the 1979 to 2024 period using ERA5. The largest warming is an areas of open water that were previously sea ice covered along the Siberian side of the Arctic. These trends exceed 2Β°C/decade in these areas.

Polar stereographic map of 2-m temperature trends in units of Β°C per decade over the Arctic for the month of October. Trends are calculated over the 1979 to 2024 period using ERA5. The largest warming is an areas of open water that were previously sea ice covered along the Siberian side of the Arctic. These trends exceed 2Β°C/decade in these areas.

October has observed some of the largest warming trends in the #Arctic. This is greatest over areas with a lack of sea ice cover (nearly all of the Siberian Arctic). Arctic amplification is largest in the boreal fall.

Data: doi.org/10.24381/cds.... Info: doi.org/10.1175/BAMS....

06.10.2025 21:12 β€” πŸ‘ 104    πŸ” 35    πŸ’¬ 3    πŸ“Œ 7
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Don’t Lose Hope: Jane Goodall’s Last Interview and Today’s Stories of Progress That Prove Her Right Plus: A Nobel Prize for genetic scissors, young climate activists triumph at the ICJ, a dinosaur caught mid-meal, and why women outlive men

Jane Goodall's last interview released: "Don't lose hope." Today's stories prove she was right.
Take a moment to listen to her words:

daybreaknotesandbeans.substack.com/p/dont-lose-...

06.10.2025 20:23 β€” πŸ‘ 21    πŸ” 7    πŸ’¬ 3    πŸ“Œ 0
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Insect Architecture The essential illustrated guide to the ingenious techniques that insects use to construct an astounding array of natural structures, from nests to shelters to traps

This ‡️ is on my XMas/bday 🎁 wish list! πŸŽ„πŸ˜πŸ˜ @princetonupress.bsky.social

press.princeton.edu/books/hardco...

06.10.2025 19:42 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1

πŸ’πŸ“βœοΈπŸœ

πŸ˜‰ #Booksky

06.10.2025 19:32 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
Preprint mandates gather momentum - openRxiv By Richard Sever, PhD. Chief Science & Strategy Officer, openRxiv Preprints speed up science by enabling researchers to disseminate reports of new findings immediately. They also represent a simple wa...

New blog post. In which I analyze the new HHMI announcement and what it means for the science publishing ecosystem openrxiv.org/preprint-man...

06.10.2025 18:53 β€” πŸ‘ 27    πŸ” 14    πŸ’¬ 0    πŸ“Œ 3
Screenshot of Avogadro2 using the interactive AutoOptimize tool to minimize a molecule (n-pentane) using the UFF force field. Text reads UFF Ξ”E = -229.80 kcal/mol

Screenshot of Avogadro2 using the interactive AutoOptimize tool to minimize a molecule (n-pentane) using the UFF force field. Text reads UFF Ξ”E = -229.80 kcal/mol

If you've been wondering about the status of the AutoOptimize interactive optimization in Avogadro2 - coming later this month πŸ‘€

06.10.2025 13:56 β€” πŸ‘ 11    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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T-reg Cells: The 2025 Medicine Nobel

The latest in a long series of Nobels for work in immunology - and it won’t be the last (!)

06.10.2025 17:12 β€” πŸ‘ 55    πŸ” 14    πŸ’¬ 1    πŸ“Œ 2

Roberto Car and Michele Parrinello are on my #ChemNobel ballot for 2025 and for every year until they'll get it 😎

06.10.2025 17:09 β€” πŸ‘ 10    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

#NobelPrize week starts tomorrow & the #chemnobel is Wednesday… used to be so much Nobel chat on Tw*tter, but that is not replicated here, alas. Anyway, for the record, I think MOFs will win at some point (maybe this year maybe not). Balasubramanian & Klenerman a good bet for next-gen sequencing too

05.10.2025 17:37 β€” πŸ‘ 112    πŸ” 19    πŸ’¬ 25    πŸ“Œ 5
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Nobel Prize in Physiology or Medicine 2025 The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi β€œfor their discoveries ...

Our Collection celebrating the 2025 Physiology or Medicine #NobelPrize is now live!

06.10.2025 16:10 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

06.10.2025 13:36 β€” πŸ‘ 41    πŸ” 19    πŸ’¬ 1    πŸ“Œ 4
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After months in limbo, four NIH institute directors fired Two leaders removed by Trump administration had hoped to stay at agency as in-house investigators

Diana Bianchi out at NICHHD. Hard to see a good reason for letting such a talented individual go www.science.org/content/arti...

06.10.2025 12:49 β€” πŸ‘ 10    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

Wow, this is a thing of beautyπŸ§ͺ 😍😍

06.10.2025 12:42 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Friday Forum – What is socially responsible science? What is science for humanity? Each Friday Forum (part of The Good Science Project) looks at one aspect of research culture at Imperial College London, and aims to foster discussion and debate about the way we work as scientists. T...

Join us at lunchtime @imperialcollegeldn.bsky.social on Fri 24th Oct to discuss the past, present and future of socially responsible science.
www.imperial.ac.uk/events/19845...

06.10.2025 11:42 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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The official website of the Nobel Prize - NobelPrize.org The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

"Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi made groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body"

Brilliant achievement πŸ‘πŸ»πŸ‘πŸ»πŸ‘πŸ»πŸ‘πŸ»πŸ‘πŸ»πŸ‘πŸ»πŸ†

www.nobelprize.org

06.10.2025 11:22 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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