Mark Blaser, PhD

Frontiers | Advances in Transplantation and Organ Preservation This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. This collection will showcase cutting-edge advance...

ISACB x FCVM Research Topic #3:

"Advances in Transplantation and Organ Preservation"

Submit your research articles today!

www.frontiersin.org/research-top...

Frontiers | Rheumatic Heart Disease: Global Trends and Emerging Mechanisms This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. Despite significant advances in global health, Rhe...

ISACB x FCVM Research Topic #2:

"Rheumatic Heart Disease: Global Trends and Emerging Mechanisms"

Submit your research articles today!

www.frontiersin.org/research-top...

Frontiers | Novel Mechanisms and Innovations in Calcific Aortic Valve Disease and Aortic Stenosis This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. Aortic stenosis, largely driven by calcific aortic...

ISACB x FCVM Research Topic #1:

"Novel Mechanisms and Innovations in Calcific Aortic Valve Disease and Aortic Stenosis"

Submit your research articles today!

www.frontiersin.org/research-top...

Abstract submission is now open for the ISACB 2026 Biennial Meeting!

Join us on Nov 11-14, 2026 in Miami! 🌴🫀🧪

Submit your science by April 20th, 2026:

fiu.qualtrics.com/jfe/form/SV_...

Join our Cloud HD Video Meeting Zoom is the leader in modern enterprise cloud communications.

ISACB Webinar: March 3rd, 2026

🚨 Calling all early-career researchers! 📢

Ahead of ISACB Miami, join us for an interactive webinar to get to know young research group leaders from our society!

5:00pm CET / 11:00am EST / 8:00am PT / 4:00pm UTC

us02web.zoom.us/j/2235938651...

Graphic of CHD facts: 1% of newborns are born with a congenital heart defect (CHD) every year 15-20% of CHDs are related to genetic conditions. A baby’s risk of having a CHD is at least three times more likely if their parents have a CHD. More than 2.4 million US children and adults are living with a CHD. About 1 in 4 babies with a CHD have a critical CHD. Infants with critical CHDs generally need surgery or other procedures in their first year of life. CHD treatment helps kids live into adulthood.

Yesterday marked the start of congenital heart disease week. #CHD affects 1 in 100 births. 25% of babies will require surgery or intervention to save their lives. Learn more about defects & how you can help at: www.heart.org/en/health-to... 🧪

You too!!

Sex-resolved Plasma & Tissue Proteomics of 👤Calcified Aortic Valve Stenosis

Tissue
♂️Fibrotic➡️Nucleotide & Cholesterol metab
♂️Calcified➡️Acute Inflamm, γ carboxyl
♀️Fibrotic➡️Platelet-Collagen Ad
♀️Calcified➡️Spectrin cytosk

@markcblaser.bsky.social #ATVB 2025
www.ahajournals.org/doi/10.1161/...

Thank you @haoyin.bsky.social!

I love this whole article so so much! Had no idea it's peak Canadian!

Circulation Research | Editorial Board | AHA/ASA Journals

I'm delighted to have been appointed as a member of @ahajournals.bsky.social Circulation Research's Early Career Editorial Board for 2025-26!

Thank you to @janefreedmanmd.bsky.social, @drkoupenova.bsky.social, & Gemma Bridges-Lyman for this selection.

www.ahajournals.org/res/editoria...

Thank you Hao!

Thanks to all our huge collaborative team, including Francesca Bartoli-Leonard, Florian Schlotter, Hideyuki Higashi, Shiori Kuraoka, Taku Kasai, Mandy Turner, Tan Pham, Katelyn Perez, Simon Robson, Simon Body, Danny Muehlschlegel, Masanori Aikawa, Sasha Singh, & Elena Aikawa!

Using network medicine approaches, we ID’d profiles of sex-specific pathogenic protein accumulation, mapped ATP catabolism to ♂ & extracellular matricrine signaling to ♀, & validated sex-specific targets.

Via MS plasma proteomics of ♂ & ♀ with #AS, we present a circulating proteome with sex-specific enrichment of inflammation vs. metalloendopeptidase activity, & new sex-stratified analysis of our disease stage-specific #AS tissue MS (www.ahajournals.org/doi/10.1161/...) ID’d ~400 dimorphic proteins.

Despite #AS being ~3x more prevalent in ♂, ♀ have ↓ timely intervention, ↑ symptoms, ↓ function, & ↑ mortality during valve replacement surgery. Seminal histo studies (www.ahajournals.org/doi/10.1161/...) found that ♀ have ↑ valvular fibrosis... but why??

Excited to have this work from Casey Clift & myself out in #ATVB!

We leverage mass spectrometry proteomics of human plasma & aortic valve tissues to assess potential drivers of sexual dimorphism in #AS aortic valve stenosis.

Mini-explainer thread below!

www.ahajournals.org/eprint/MF7VI...

Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Calcific aortic valve stenosis is a global clinical burden, impacting around 2% of the population over 65 years of age. No pharmacotherapeutics exist, with surgical repair and transcathete...

Member publication alert:

Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis

www.ahajournals.org/doi/10.1161/...

ISACB is searching for candidates to serve as new members of our Committees and Executive Council!

We welcome applications from members at all career stages who wish to contribute to the growth of our society.

Please apply now via: forms.gle/2E1eyPznNJXn...

Save-the-Date for #ISACB2026 in #Miami!

We are excited to announce that the next Biennial @appliedcvb.bsky.social ISACB meeting will be held in beautiful #Miami from November 11-14, 2026.

Be sure to save the date in your calendar! More details coming soon.

oh the irony...

You haven’t really written an academic paper until you’ve cut the paragraph you built the entire paper around.

Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Carotid atherosclerosis is orchestrated by cell-cell communication that drives progression along a clinical continuum (asymptomatic to symptomatic). Extracellular vesicles (EVs) are cell-d...

Member publication alert:

Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks

www.ahajournals.org/doi/10.1161/...

Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Carotid atherosclerosis is orchestrated by cell-cell communication that drives progression along a clinical continuum (asymptomatic to symptomatic). Extracellular vesicles (EVs) are cell-d...

How does EV–vascular cell communication drive dynamic changes in atherosclerotic plaques?

www.ahajournals.org/doi/10.1161/...

Long-weekend vibes!

Take Action Today on CHFRA

Join @ACHA_Heart and millions of patients with #CHD in asking Congress to fund the Congenital Heart Futures Reauthorization Act of 2024. This legislation is vital to fund CHD research👇

#ACHD #ACCACPC #cardiosky #medsky

www.achaheart.org/get-involved...

Thanks for the kind words @nautilus.bio!

I had a fantastic time at my first @us-hupo.org #USHUPO2025, sharing our work on multi-omics of aortic valve stenosis!

Cassandra Clift, postdoc in Elena Aikawa's lab, presents her poster full of exciting research on proteomics as it applies to cardiovascular biomaterials at #USHUPO2025

Dr. Taku Kasai of @toleafgirl.bsky.social ‘s Proteomics group shares new in-source CID HCD fragmentation technologies for ADPr in human primary macrophages with fellow proteomics enthusiasts at @us-hupo.bsky.social #USHUPO2025