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Vojtech Spiwok

@spiwokv.bsky.social

Molecular modeling, simulations, metadynamics, machine learning

831 Followers  |  1,962 Following  |  127 Posts  |  Joined: 13.11.2024
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Posts by Vojtech Spiwok (@spiwokv.bsky.social)

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Ancient amino acid sets enable stable protein folds Early proteins likely arose from a chemically limited set of amino acids available through prebiotic chemistry, raising a central question in molecular evolution: could such primitive compositions yie...

Can proteins fold and function with half of the amino acid alphabet?
Using only 10 residues, we designed stable, mutation-resilient structuresβ€”no aromatics or basics involved.
A minimalist foundation for ancient biology and synthetic design. tinyurl.com/37t8br4v
#ProteinDesign #OriginsOfLife

03.11.2025 16:48 β€” πŸ‘ 25    πŸ” 11    πŸ’¬ 1    πŸ“Œ 0
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22nd Structural Biology Club online on 26th November 2025, 1pm CE: Structures in solution: BioSAXS at BM29 ESRF
by Petra Pernot & Cryo-EM data processing in CCP-EM Doppio
by Colin M. Palmer cssb.structbio.org/22nd-structu...

23.10.2025 15:16 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Homology modeling

10.10.2025 16:17 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Gruezi!

02.10.2025 07:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Protein Production Hands-On Workshop Dates: December 2 – 4, 2025 Venue: BIOCEV, Vestec Registration Deadline: October 31, 2025 Cost: Free of charge (accommodation not included) Registration Link: forms.biocev.org/index.php/14... Workshop Page: www.ibt.cas.cz/en/core-faci...

02.10.2025 07:44 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

Thanks!

24.09.2025 15:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Protein design by parallel tempering in the sequence space
YouTube video by Vojtech Spiwok Protein design by parallel tempering in the sequence space

youtu.be/4n4awaRnEOY

24.09.2025 14:59 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Protein design by parallel tempering in the sequence space
YouTube video by Vojtech Spiwok Protein design by parallel tempering in the sequence space

youtu.be/4n4awaRnEOY

24.09.2025 14:57 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Our first protein design paper out in Protein Science
onlinelibrary.wiley.com/doi/10.1002/...

24.09.2025 14:53 β€” πŸ‘ 14    πŸ” 4    πŸ’¬ 3    πŸ“Œ 0
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Pranam Chatterjee @pranam.bsky.social and his first AI-generated baby #CecamLLMLugano

24.09.2025 09:19 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

#CecamLLMLugano

24.09.2025 08:50 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Traveling to "Generative AI and large language models for protein modeling across sequence-structure-function scales : From predicting protein dynamics to programmable biology and drug design" in Lugano #CecamAILugano @cecamevents.bsky.social

24.09.2025 08:26 β€” πŸ‘ 10    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
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Max Bonomi @bonomimax.bsky.social on IDP modeling by AI @cecamevents.bsky.social #CecamLLMLugano

24.09.2025 08:23 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Prof. Michele Vendruscolo
Dr. Zsuzsanna DosztΓ‘nyi
ML4NGP Connect series, organized as part of the ongoing activities of the ELIXIR 3D-BioInfo Community and in collaboration with ISCB and 3DSIG.
πŸ“’ Date & Time: 30 September 2025 | 17:00-18:00 CEST
Online elixir-europe.org/events/unstr...

09.09.2025 10:18 β€” πŸ‘ 8    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Happy birthday ČSBMB #CSBMB2025

07.09.2025 17:32 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Hana CahovΓ‘ ( @iocbprague.bsky.social ) awarded a medal by CSBMB #CSBMB2025

07.09.2025 15:21 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

#csbmb2025

07.09.2025 15:19 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Followed by awards

07.09.2025 14:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Kickoff of XXVIII-th congress of the Czech Society for Biochemistry and Molecular Biology ( @febspress.bsky.social member )

07.09.2025 14:30 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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πŸ§€

22.08.2025 15:40 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
New Horizons in Protein Dynamics – Department of Biology - University of Copenhagen

Instruct Director Harald Schwalbe will be in Denmark for the SBiNLab’s 25th anniversary!

www1.bio.ku.dk/english/rese... @schwalbe-lab.bsky.social

Researchers in Denmark can receive access to Instruct technologies and instrumentation here - instruct-eric.org/submit-propo...

22.08.2025 15:22 β€” πŸ‘ 5    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Many thanks to @pluskal-lab.org @iocbprague.bsky.social @elixircz.bsky.social for two days of excellent talks at #PragueBioML !

22.08.2025 15:32 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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And now something completely different - nanopores! by @scimartin.bsky.social @ethz.ch #PragueBioML @elixircz.bsky.social

22.08.2025 15:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Erik Andris @iocbprague.bsky.social on graph NNs #PragueBioML @elixircz.bsky.social

22.08.2025 15:05 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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"Second talk" by Anton Bushuiev ( @iocbprague.bsky.social @pluskal-lab.org @josef-sivic.bsky.social ) on protein language models #PragueBioML @elixircz.bsky.social

22.08.2025 14:49 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Intrinsically disordered proteins by @tothpetroczylab.bsky.social #PragueBioML @elixircz.bsky.social

22.08.2025 14:13 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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In 2024, IT4Innovations supported thousands of users and hundreds of research projects.

Behind every achievement stand people – our colleagues, partners, and supporters – thank you for making it possible.

πŸ‡¬πŸ‡§ www.it4i.cz/cs/file/e5d7...

#eINFRAcz

22.08.2025 13:24 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Petr Kouba on protein flexibility #PragueBioML @elixircz.bsky.social

22.08.2025 13:18 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Joan Planas-Iglesias on protein aggregation #PragueBioML @elixircz.bsky.social

22.08.2025 13:01 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Stanislav Mazurenko on evolution and protein design #PragueBioML @elixircz.bsky.social

22.08.2025 12:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0