Yori Dola

YouTube video by Forbrukerrådet - Norwegian Consumer Council A Day in the Life of an Ensh*ttificator

I think everyone should watch this government-funded infomercial
youtu.be/T4Upf_B9RLQ

Golden Gate 🧬 builds complex T-DNAs for plant transformation & gene editing — but what if we used it to make binary vector backbones?

Glad to contribute to Jonas De Saeger's (Jacobs lab @psb-vib.bsky.social ) preprint on BackBone Builder 🔧🌱
tinyurl.com/4ycydjhe

When viruses force the cell to make viral proteins, they also downregulate its production of native proteins using a special viral translation initiation factor (vIF4F), which has specificity to viral transcripts!

Parasitic wasps use tamed virus to castrate caterpillars A virus that became integrated into the wasp genome long ago is useful for subduing moth larvae.

Some wasps harbour the genetic material of viruses in their genome, helping them use moth larvae as living incubators for their eggs: doi.org/10.1038/d415... >> Horizontal gene transfer isn't just human-made, also nature produces transgenic organisms! #GMO #Science

This interesting study concerns aging in WORMS 🪱.

Why is it that only PLANT 🌱 researchers put their organisms’ names in paper titles?

Gedankenexperiment: Who would NOT feel deceived if a plant aging paper did not mention plants in the title?

I think you might have pasted the wrong link

Multiple protein structure alignment at scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

Multiple protein structure alignment at scale with FoldMason | Science www.science.org/doi/10.1126/...

Creating a new oilseed crop, pennycress, by combining key domestication traits using CRISPR genome editing - Nature Plants De novo domestication was performed on the brassica Thlaspi arvense (pennycress) by identifying and stacking CRISPR-induced mutations to create a new intermediate oilseed crop that can be grown in the...

Rational improvement of pennycress using CRISPR.
#PlantScience

From: www.nature.com/articles/s41...

I left Twitter when Musk started with the Nazi salutes.

Twitter has steadily progressed to generating and distributing explicit images of children.

Yet still, some friends and colleagues remain on the platform, seemingly unbothered (at least, not sufficiently).

I wonder, what will it take?

I have long been skeptical of biostimulants as a broadly-usable product in Ag 🌱 🚜

Unfortunately, that seems to have been warranted 😬

The authors made a great effort, lots of work went into this!

Some colleagues and I just published a #PreprintReview of “The parasitic plant Cuscuta campestris selectively loads trans-species miRNAs onto host Argonautes, but not self Argonautes” 📜

Another output from the NBI's #PreprintPizzaParty
🍕🍕🍕

I need a mood booster, let's talk about capybaras.

Here's a capy demonstrating one of MANY ways they can move through the water: running along the bottom.

They're 'semi-aquatic' mammals, just like hippos, seals & beavers. They LOVE water.

(📷: Fernando Maidana)

Resisting AI slop It’s hard to talk about any topic in science or education today without the subject of artificial intelligence (AI) coming up—whether large language models should be allowed to aid in searching for a ...

'Although AI is helping Science catch errors that can be corrected or elements that are missing from a paper but should be included, such as supporting code or raw data, its use and the evaluation of the output require more human effort, not less.'
www.science.org/doi/10.1126/...

It's only a war if its made in the War river valley, otherwise it's just a sparkling military operation

Genome editing in brown algae! 🧬🪸🌿 Now out in Cell Reports Methods!

Excited to share this highly efficient, transgene-free CRISPR–Cas genome editing protocol for brown algae, requiring no cloning and no specialized equipment.

doi.org/10.1016/j.cr...

#CRISPR #BrownAlgae
@mpi-bio-fml.bsky.social

Releasing alignism, a small tool that I have found useful for doing multiple sequence alignment in browser.

hgbrian.github.io/alignism/

- The hard work was done by the awesome biowasm team!
- Does tree building too
- V fast compared to e.g., muscle on EBI
- Not tested that much!

Pint jar filled with blue dry beans.

A few years ago, through luck and vibes, I managed to produce this blue colored bean variety.

This was an early step in trying to answer the question, [paraphrased] "Why isn't blue as common as red in beans, even though they're both anthocyanins and the plant has the genes for both?"

Important theoretical framework for NLR evolution.
doi.org/10.32942/X2R...

Great paper! It's always interesting to see how the public engages with such complex topics.

Will try to remember this analysis next time I talk to someone worried about NGTs 😀

UNITED24 - The initiative of the President of Ukraine UNITED24 was launched by the President of Ukraine Volodymyr Zelenskyy as the main venue for collecting charitable donations in support of Ukraine. Funds will be transferred to the official accounts of...

The recent attacks on Ukraine have got me worrying, like many Europeans.

I find anxiety flourishes in the absence of action.

If you support democracy and have the means, consider donating below.

There is a pride in knowing your support is not limited to words/posts.

u24.gov.ua

Great work! Always nice to see new GE tools published.

After the extensive optimization of TnpB & its guide, did you benchamrk its efficiency against popular GE tools (SpCas9, LbCas12a, etc.)?

A guide to designing cell-surface receptors in plants Cell-surface receptors perceive environmental cues and trigger appropriate responses. In plants, these receptors comprise ectodomain, juxta-membrane, …

We wrote a review on the mᴏdular properties of plant cell-surface receptors, and how this knowledge can be used to reprogram and engineer them:
www.sciencedirect.com/science/arti...

Very cool!
GE made a grass easier to convert into biofuels.

Making plants more suitable to second-generation biofuel production is one of the coolest uses of GE.

A big open question is how well such plants resist bio- & necrotrphs. Plants ultimately evolved lignin for a reason.

#plantgene

K-State researchers aim to reduce gluten allergenicity in wheat Kansas State University researchers and the state’s farmers are putting their collective support behind a project to reduce the allergenicity of gluten in wheat, while maintaining the grain’s ability ...

🌾Researchers of @kstate.bsky.social are collaborating with farmers and using #CRISPR #GenomeEditing to reduce gluten allergens in wheat, whilst maintaining high quality for bread.

🎯Goal: safer food options for people with celiac disease

www.ksre.k-state.edu/news-and-pub...

Ich möchte gentechnisch veränderte Lebensmittel essen. Nach vielen Jahren gibt mir diese Gesetzgebung diese Wahlmöglichkeit. Dies ist ein klarer Sieg für die Wahlfreiheit der Verbraucher, und jeder, der sich aus diesen Gründen dagegen ausspricht, ist zutiefst verwirrt.

Is there a decent R package for estimating a suitable bin number?

That's really cool! I wonder how they figure out what to use. Maybe it's half-informed, half stochastic process 🤔

So, the poly-specialist theory predicts generalist pathogens have an expanded number of effector genes whose expression differs markedly depending on what host they are infecting?

Not aware of such findings, although this isn't really my field.

Are those two hypotheses meaningfully different? What are some testable predictions which stem from one but not the other?
(honest question)

Pleased to share this thoughtful essay by Jess on my flower design project🌹🧬

As a small thank-you for spreading the work, I'm randomly giving away 5 of these new morphogenesis hoodies to whoever reposts this!