Laura Santini

It was great to be there and see your lab blossoming! All the best for next 10 years and more to come 🎊🎊

Start the weekend by checking out the latest paper from the Vierbuchen lab, spearheaded by amazing @danielmedinacano.bsky.social 🎉 Congrats to all authors!!

Modeling tissue-resident macrophage development from mouse pluripotent stem cells Tissue-resident macrophages (TRMs) are innate immune cells that participate in tissue development, homeostasis, and immune surveillance. Extensive efforts have been made to recapitulate TRM developmen...

Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.

www.biorxiv.org/content/10.1...

So glad this great story is finally out! Congrats to all authors!

A MOUSE ORGANOID PLATFORM FOR MODELING CEREBRAL CORTEX DEVELOPMENT AND CIS-REGULATORY EVOLUTION IN VITRO Natural selection has shaped the gene regulatory networks that orchestrate the development of the neocortex, leading to diverse neocortical structure and function across mammals, but the molecular and...

Happy to share our mouse cortical organoid system, which recapitulates in vivo tempos and cell types. We used it to identify gene expression changes across subspecies during development, which might underlie neuroanatomical differences and affect disease penetrance. www.biorxiv.org/content/10.1...