Otoniel Rodriguez

Algunos de mis alumnos (as) durante el Congreso Nacional de Inmunología, en Chihuahua. @sminmunologia.bsky.social

Mañana comenzamos!!

@biorxivpreprint.bsky.social CD8+ T cells regulate the bioenergetic reprogramming of lymphoid organs and the heart during viral infection
www.biorxiv.org/content/10.1...

A variational deep-learning approach to modeling memory T cell dynamics Author summary After an influenza infection, antibodies provide strong protection—but only against the same strain. Because influenza rapidly mutates its surface proteins, this protection soon becomes...

Our TRM modeling paper is now published in PLOS Computational Biology! In this paper, we fit dynamical (ODE) models to single-cell flow cytometry data using a variational autoencoder that has a GMM with time-dependent weights as prior. journals.plos.org/ploscompbiol...

Stem-like peripheral helper T cells seed effector peripheral helper T cells in rheumatoid arthritis @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Succinate enhances mitochondrial fitness and induces epigenetic reprogramming to promote CD8+ T cell stemness, thereby augmenting antitumor immunity
www.cell.com/immunity/ful... @cp-immunity.bsky.social

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...

Our paper is out! Check out this beautiful story where we uncovered that the costimulatory molecule ICOS is detrimental for PD-1+ CD8 T cells.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...

T follicular helper and regulatory cells in human lymphoid tissue mature distinctly, defined by PD-1 and ICOS protein levels @lgraca.bsky.social
www.science.org/doi/10.1126/...

Biological Sex Influences Human Bystander CD8+ T Cell Activation CD8+ T cells isolated from male donors exhibit greater IL-15–driven bystander activation, NKG2D expression, and cytotoxicity than female CD8+ cells. This study reveals a sex-based difference in innat....

'Male CD8+ T cells stimulated with IL-15 exhibited greater bystander activation, including increased NKG2D expression and greater antigen-independent cytotoxicity against tumor cells compared with female CD8+ T cells.'
#immunology #immunosky

onlinelibrary.wiley.com/doi/10.1002/...

🧬 CD28 vs. TCR: not a one-size-fits-all signal.

New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.

📖 https://bit.ly/44MG7UD

#Tcells #Immunology

Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans @cp-cellreports.bsky.social
www.cell.com/cell-reports...

🔔¡Ampliamos la fecha de recepción de resúmenes del 3 al 10 de julio!

No queremos que te pierdas la oportunidad de presentar tu trabajo en el XXVI Congreso Nacional de Inmunología.

¡No olvides subir tu resumen. Te esperamos!

🔗Link en la bio

#SMInmunologia #CongresoMexicanoDeInmunologia

Purinergic signaling modulates CD4+ T cells with cytotoxic potential during Trypanosoma cruzi infection @jclinical-invest.bsky.social
www.jci.org/articles/vie...

Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Succinate induces Treg dysfunction by inhibiting succinyl-CoA generation. Succinyl-CoA is necessary for FOXP3 succinylation and protection of FOXP3 from proteasome degradation.

Wang et al – 2025 @natureportfolio.nature.com
www.nature.com/articles/s41...

Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells Nature Immunology - Klein and colleagues show that the lysosomal cysteine protease cathepsin L shapes the diversity and optimizes the fitness of clones that enter the CD4+ T cell repertoire.

Klein and colleagues find that cathepsin L shapes CD4+ T cell selection by promoting full repertoire diversity and fine-tuning CD4+ T cell functionality. Read it here: rdcu.be/etDy2
www.nature.com/articles/s41...

📢 ¿Listo para llevar tu conocimiento al siguiente nivel? 🔬💻📝🌱

💡 Explora, actualízate y vive la experiencia de los Cursos Pre-Congreso.
📅 27 de septiembre | Modalidad presencial
🎟 ¡Cupo limitado!

🔗 Más detalles en: sociedadmexicanadeinmunologia.org/xxvi-congres...

🏳️‍🌈 El Comité de Equidad, Diversidad e Inclusión de la Sociedad Mexicana de Inmunología te invita a su seminario extraordinario este 24 de junio. 🏳️‍🌈
Regístrate en la página de la SMI:
sociedadmexicanadeinmunologia.org/seminario-ex...

Se extendió la fecha!. Nos vemos en Chihuahua en el Congreso de la SMI!. #Inmunologia @sminmunologia.bsky.social

Genomic analyses of mother–father–fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...

🚨 ¡Recuerda, el próximo lunes 9 de junio es la fecha límite para el envío de resúmenes!

No olvides enviar tu trabajo al XXVI Congreso Nacional de Inmunología. Te queremos ver ahí 😉

🔗 Link en la bio

#SMInmunología #CongresoDeInmunología #Chihuahua2025

Cada vez más cerca. Nos vemos en el Congreso Nacional de Inmunología en Chihuahua! @sminmunologia.bsky.social
@marionbrunck.bsky.social @kempisla.bsky.social @eugecc.bsky.social
Y más...

Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells
www.annualreviews.org/content/jour...

Review @annualreviews.bsky.social @tsanglab.bsky.social
Systems Human Immunology and AI: Immune Setpoint and Immune Health
www.annualreviews.org/content/jour...

A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours - Nature Metabolism Through a functional CRISPR/Cas9 screening, Pretto et al. identify Elovl1 as a target to improve antitumour immunity by remodelling T cell lipid metabolism.

RESEARCH | S Pretto, M Mazzone et al. (KU Leuven, BE)

The authors identify Elovl1 as a target to improve antitumour immunity by remodelling T cell lipid metabolism.