Muhammad Saad, MBBS

1/ 🚨 Are we denying older adults a life-saving therapy?

Our meta-analysis (32,541 older adults) shows SGLT-2 inhibitors significantly reduce mortality, heart failure hospitalizations, and major cardiac events.

Yet, they remain underused. Why? 🧵👇

#CardioSky

Obesity paradox in coronary artery disease: national... : Coronary Artery Disease CAD from 2018 to 2020. The study cohort was stratified into six BMI categories: underweight, normal weight, overweight, class I obesity, class II obesity, and class III obesity. Using multivariable lo...

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💡 Also notable:

Underweight & normal-weight groups had the longest median LOS (5 days)
Overweight patients saw highest total charges (~$53K) despite shorter stays.
The full article dives deeper into the paradox—link below! 📖

journals.lww.com/coronary-art...

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After adjusting for confounders:

Underweight status was associated with 38% higher odds of mortality vs. normal weight (OR=1.38)
Overweight & obesity were protective, with class I obesity showing 46% lower odds of mortality (OR=0.54). Could higher BMI actually help in #CAD outcomes?

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Here’s the kicker:

Underweight patients had the highest in-hospital mortality (6.8%),
Normal weight: 5.2%
Overweight: 3.2%
Class III obese: 2.5%
Class I & II obese: ~1.9% - 1.8%
Yes, mortality was lowest in obese groups! Curious why?

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Ever heard of the #ObesityParadox in #Cardiology? 🫀 Our new study on Coronary Artery Disease (CAD) explored how BMI, from underweight to class III obesity, impacts key hospital outcomes using data from >3.6M hospitalizations in the National Inpatient Sample.
#CardioSky #MedSky

Congratulations Eliza!

Delighted to announce that five of our abstracts have been accepted for presentation at the 74th American College of Cardiology Annual Scientific Session (ACC.25)! @accintouch.bsky.social

#MedSky #CardioSky

Thrilled to share my first publication as lead author in The American Journal of Cardiology! Our study challenges traditional fasting before cardiac catheterization—finding no significant differences in key clinical outcomes, but better patient satisfaction with non-fasting.

#CardioSky #MedSky

Our abstracts are now available online in Circulation and will be presented at the upcoming #AHA24 in Chicago! Congratulations to all the co-authors for their hard work and dedication.