We’re hiring post-docs! Join our lab on projects involving immunotherapy and therapy resistance and metastasis in cutaneous and uveal melanoma. Please DM if interested!
10.05.2025 11:49 — 👍 0 🔁 0 💬 0 📌 0
5/The project was only possible because of collaboration with the Van Allen lab, talented co-first authors Julia Schiantarelli, Mouadh Benamar, Jihye Park. I am grateful to patients who donated biopsy material and funding sources, including @melanomaresearch.bsky.social @danafarbernews.bsky.social
10.02.2025 16:08 — 👍 1 🔁 0 💬 1 📌 0
4/and a reduced capacity to activate cytotoxic T cells.
10.02.2025 16:08 — 👍 0 🔁 0 💬 1 📌 0
3/Strikingly, we found resistance-associated mutations in SEC24C and SEC24D in 3 patients. Melanoma cells engineered to express the SEC24C mutations observed in patients exhibit diminished STING signaling, including decreased Type I interferon production, antigen presentation
10.02.2025 16:06 — 👍 0 🔁 0 💬 0 📌 0
2/Over several years, we collected matched pre-treatment and post-resistance tumor biopsies in patients with metastatic melanoma who exhibited heterogeneous ICI responses to nominate additional mediators of acquired resistance.
10.02.2025 16:06 — 👍 0 🔁 0 💬 0 📌 0
1/Although some patients with metastatic melanoma experience durable responses to immune checkpoint inhibitors, most exhibit intrinsic or acquired resistance to these therapies.
10.02.2025 16:06 — 👍 0 🔁 0 💬 0 📌 0
https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00027-3
Our paper on a new mechanism of resistance to immunotherapy in melanoma is now in print
@Cancer_Cell
with the @vanallenlab.bsky.social t.co/TCC4brc6yb
10.02.2025 16:05 — 👍 3 🔁 0 💬 0 📌 1
Functional genomics @ Broad Institute. Screen all the things!
Deputy Editor at Cancer Cell | Cancer bio | Science | Opinions my own | Se habla español
We construct systematic key datasets and analytical and visualization tools to accelerate precision cancer medicine
Explore the data: https://depmap.org/portal/
Scientist working on signaling and metabolism in cancer, metabolic diseases, aging, and physiology. AKT-TSC-mTOR🧪
I still like small data but I'm not opposed to big data. We study #metabolism, #genetics, #pediatric inborn errors & cancer.
Director of Children's Research Institute at UT Southwestern (@cri_utsw.bsky.social) & Howard Hughes Medical Institute Investigator. My lab studies stem cells & cancer. I sit at a computer, grateful that I can "do" science. Views are mine. 🇨🇦🇺🇸
Breast cancer physician-scientist | Clinical computational oncology
@OSUCCC_James | Vice Chair, @Alliance_org Breast Cmte | Views own | http://u.osu.edu/StoverLab & https://u.osu.edu/bctrp
Targeting metabolic mechanisms of metastasis. Ferroptosis, lymph & lipid enthusiasts.
Professor, University of Lausanne 🇨🇭 and Ludwig Institute for Cancer Research
President-Elect, European Association for Cancer Research
Mentor, Teacher, Advocate, Mum
@joycelab.bsky.social
Redox biology and cancer metabolism @ Moffitt Cancer Center. Views my own.
The Laboratory for Lymphatic Immunobiology at NYU Langone Health. Studying lymphatic transport, immunology, and cancer. www.thelundlab.com
We are dedicated to understanding and ultimately helping treat cancer
Led by @johannajoyce.bsky.social
@unil.bsky.social, @ludwigcancer.bsky.social, @fbm-unil.bsky.social
www.joycelab.org; https://agora-cancer.ch/laboratory/joyce-lab/
Professor of Immunology, Department of Pathology, University of Cambridge.
Research interests: PI3K, immunity, infection, cancer, immunotherapy.
Researching Cell Signalling at the Babraham Institute @babrahaminst.bsky.social Walker; watching woodpeckers; tree hugger; listening to The Jam. European. Views my own. I could go on for hours and I probably will....
Cell Bio@Harvard Med- dedicated to unraveling how the machines of the cell work. Specializing in membrane/organelles, ubiquitin & protein quality control, chromatin regulation, proteomics, metabolism, and sensory perception.https://cellbio.hms.harvard.edu/
Associate Professor at MGH Krantz Center for Cancer Research and Harvard Medical School Department of Medicine. Intersection of signaling, metabolism and chemical biology.
Imagine understanding cancer on a neighborhood level—not just cell by cell. In our lab, we’re combining spatial biology and AI to study cancer in ways that could redefine precision medicine.
What excites you about AI in healthcare? Let’s discuss!
The Sarosiek Lab @HarvardChanSPH studies the regulation of #apoptosis in human development and diseases, especially cancer.
Associate Professor at University of Barcelona (Campus Clínic). Leading the Cell death, senescence and cancer precision medicine group. ICREA Acadèmia awardee. Former IBEC/DFCI/HMS. Board member of the SfPM. www.themonterolab.com
The European Association for Cancer Research has 14,000+ members. Our aim? Advancing cancer research 🥼🔬🌍 #KeepResearchCurious
www.eacr.org
