Cascales Lab

Very happy that our work on the T6SS ADP-ribosylcyclase toxin made the Cover at JBC @asbmb.bsky.social y.social ! Congratulations Julius @jmartinkus.bsky.social for designing this Cover !
@dukasju.bsky.social @laurentterradot.bsky.social

Nous recrutons un Maître ou une Maîtresse de conférences en bactériologie moléculaire pour notre équipe MTSB au laboratoire MAP à Lyon, France.
Le poste combine recherche sur l'adaptation des bactéries phytopathogènes et enseignement en génétique microbienne.
Notre team : sites.google.com/view/mtsb

We are starting 2026 by looking for candidates to apply for the Junta de Andalucía PhD fellowship. If you are interested in bacterial secretion systems and molecular biology, get in touch. More info about our work: personal.us.es/pbguzman/ & regarding the call www.investigacion.us.es/convocatoria...

Co-option of an ancestral peptidase controls developmental patterning in multicellular cyanobacteria Developmental biology

How do simple cells make complex patterns? We discovered a key piece in cyanobacteria—an ancient enzyme repurposed to activate a pattern-forming signal. A conserved signaling strategy, showing how nature reuses tools to build multicellularity. www.cell.com/iscience/ful...

Congratulations !!

Very sad news. Alain will be missed.

Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...

Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...

🚨PhD position alert🚨

🔬Cryo-EM? ✅ 🧫Membrane proteins? - we've got 165 TMs for you! ✅

Join me and the team👥 in beautiful Amsterdam🚴 to untangle the amazing mycobacterial protein secretion machinery!

📝Apply here: tinyurl.com/mmxnfpnw

📆Deadline: 23 January

#PhDstudent #T7SS #cryoEM #newPI

Congratulations Calum, Marie & co !!

Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...

Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social

www.nature.com/articles/s42...

Congratulations Ronnie !

Applications closing tonight (midnight French time) !!!
Still a few hours to apply !!

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com

PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging

Congratulations Irene !

Congratulations Chloé !!

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...

Amazing science at the 2nd edition of the Secretion Days in Marseille 🌞 ! Huge thanks to all participants and to @archaellum.bsky.social for an outstanding opening talk. Looking forward to the next edition!

Bravo @ben-ezraty.bsky.social et al !!

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...

Extremely happy to share the fruit of a beautiful collaborative research study.

France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺

Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇

doi.org/10.1101/2025...

We will have soon an Open position for a PhD thesis position to work on bacterial secretion systems !

Stay tuned !!

Open position !!
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...

This work complements the great work published in July on a T7SS effector with ADP ribose cyclase activity, by Jake Collauti and John Whitney
www.jbc.org/article/S002...

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems. Here, we ...

Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...

We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested:

emploi.cnrs.fr/Offres/CDD/U...

Welcome - LISM The research topics of the LISM today remain centered on biological membranes and in particular membranes of Gram-negative bacteria. Since […]

Le LISM (lism.imm.cnrs.fr) propose une mobilité en NOEMI pour travailler sur des assemblages de l'enveloppe bactérienne. Profil microbiologie, biologie moléculaire, avec une envie de faire de la biochimie, de la microscopie ou de la biologie cellulaire ! Rejoignez une unité dynamique !!

Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

For those interested on the bacterial envelope and on secretion system: a 2-day symposium in Marseille ! Second edition of the Secretion Days !

I understand now why you wanted to go to Compostelle ! 32 days to go (and how many beers ??) ! 😂

You are a young researcher working on the bacterial cell envelope ? Don't miss this opportunity !!