SyNergy - Munich Cluster for Systems Neurology

🧠 Synaptic #Dopamine Storage Defect Uncovered as Key Mechanism in #Parkinson’s Disease Neurons.

🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

🧠CD38 Shields #CNS Tregs From Post-Inflammatory Stress. The study shows that regulatory #Tcells persist in the CNS after the acute phase and are essential to prevent local relapses.

🔗Read a summary of the study on our website: www.synergy-munich.de/aktuelles/ne...

🧠 TREM2 Levels Shape Microglial Metabolic Fitness. This study shows that microglial #TREM2 is not an on/off signal but a graded axis that tracks with microglial state and function.

🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Outstanding work! – Congratulations to SyNergy member Fabian Theis!

Congratulation to SyNergy member Mikael Simons!

🧠 Zebrafish compass neurons learn visual anchoring. Using panoramic virtual reality and two-photon imaging, we show that larval #zebrafish head-direction neurons track complex visual scenes.

🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

🧠✨ Dive into #neurodegeneration at the SyNergy #ScienceDay on February 3, 2026! (in German)
Medical students get inspiring talks, expert discussions, and an emotional #Alzheimer film through Cineducation.
Curious? Join the journey from lab to clinic!
#MedicalStudents #TranslationalTeaching

🧠New blood test shows the extent of brain injury after #stroke – and reveals treatment effects. Bood #biomarker brain-derived #tau (BD-tau) can track acute brain injury after ischemic stroke over time.

🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Neuer Kurs: Die #Alzheimer-Erkrankung – Dieser Kurs richtet sich an alle, die sich für das Thema Alzheimer interessieren: an Sie als Betroffene, Angehörige, interessierte Laien oder medizinische Fachkräfte. In Zusammenarbeit mit dem SyNergy Cluster.

www.synergy-munich.de/aktuelles/ne...

🧠 Fully human #iPSC - derived 3D #BBB model with perfusable vessels and key BBB functions. #FOXF2 deletion causes BBB dysfunction, rescued by lipid-nanoparticle delivery of Foxf2 mRNA.

🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

🧠 ApoE4 lowers the p-tau217 #tauopathy threshold.
In two independent cohorts spanning preclinical and symptomatic #Alzheimer’s disease, the study tested where #ApoE4 accelerates the amyloid-to-tau transition.

🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Exzellent erklärt - Spitzenforschung für alle 57 Exzellenzcluster – ein Podcast: Regelmäßig berichtet „Exzellent erklärt“ aus einem der Forschungsverbünde, die im Rahmen der Exzellenzstrategie des Bundes und der Länder gefördert werden. Die Reise...

Welche Prinzipien der Intelligenz verbinden Mensch, Tier und Roboter? Hört rein in die nächste Folge des #Podcast #exzellenterklaert – Spitzenforschung für alle! Das Cluster Science of Intelligence erklärt. warum Grundprinzipien von Intelligenz wichtig sind.
exzellent-erklaert.podigee.io
#Wisskomm

🧠 In vivo #CRISPR screening approach identifies cytokine networks that control #macrophage function in #neuroinflammatory lesions, offering new insights into immune regulation in diseases such as #multiplesclerosis

🔗Read a summary of the study on our website: www.synergy-munich.de/aktuelles/ne...

👏 Our member Qihui Zhou, has received a grant of 100,000 Swiss francs from the Frick Foundation. Zhou and her team will take a closer look at the role of the immune system in the most common genetic form of ALS.

🔗https://www.dzne.de/en/im-fokus/meldungen/2025/funding-for-munich-als-researcher/

🏆 👏 Congratulations to our member Arthur Liesz @isd-research.bsky.social for receiving an ERC consolidator grant for his project: TRAINED - The Role of Trained Immunity in Brain-Body Communication and Secondary Organ Dysfunction.

🔗 Read more on our website: synergy-munich.de/news-events/...

Die Moleküle des Vergessens - Wie experimentelle menschliche Gehirnzellen den Weg zu Demenztherapien ebnen können Angelika Dannert, PhD, Ludwig-Maximilians-Universität München

My research at @isd-research.bsky.social, @lmumuenchen.bsky.social, @synergy-munich.bsky.social focused on more physiological, human-based models that better reflect actual disease processes - and thus contribute to the global effort towards more effective dementia treatments tinyurl.com/3thjnvzs

Congratulations @angelikadannert.bsky.social 👏

You can currently find us at #SfN25 Neuroscience 2025 in San Diego (Society for Neuroscience) as part of Neurocenters in Germany. If you're there too, let's connect - join us at booth 3917!

👃 A reduced sense of smell can be one of the first signs of Alzheimer's disease. Researchers discovered that the brain's immune system plays a significant role, indicating that it may attack neuronal fibers essential for the sense of smell.

🔗Summary on our website: synergy-munich.de/news-events/...

🏆 Our member Mikael Simons receives US$500,000 for a project to investigate disease mechanisms involving tau proteins. The funding is part of the international program „Tauopathy Challenge Workshop 2025“.

🔗 Read more at @dzne.science: www.dzne.de/en/im-fokus/...

👇Meet our member Angelika Harbauer @harbauerlab.bsky.social

🧠 A team of researchers led by Monika Leischner-Brill and Thomas Misgeld discovered that tubulin polyglutamylation plays an important role in synaptic remodeling by tagging microtubules for severing.

🔗Read a summary of the study on our website: synergy-munich.de/news-events/...

Community is key for the research career “One absolutely can change their research topic after the PhD. Indeed, it is essential to adopt new perspectives and methods during the post-doc phase,” said Professor Christian Haass, speaking at the...

💭 “The most important thing for an early career researcher is to have good mentors. Ideally, this kind of a mentoring relationship is something that will naturally develop between the doctoral researcher and their supervisor."

👉 Interview w/ @haasslab.bsky.social at UEF: www.uef.fi/en/article/c...

🏆 👏 Congratulations to our members Dieter Edbauer, Thomas Korn, and Christian Weber who each received the prestigious ERC Advanced Grant from the European Research Council (ERC)!

🔗 Read more on our website: synergy-munich.de/scrivito/new...

👏Congratulations Arthur Liesz! Liesz was awarded the prestigious ESO Scientific Excellence Award for his contributions to the understanding of stroke and neurovascular disease. The award was presented during the Presidential Session at the ESO Conference in Helsinki.
@isd-research.bsky.social

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration

@janos-groh.bsky.social @tum.de @synergy-munich.bsky.social @dzne.science

www.nature.com/articles/s41...

👏 With our member Lisa-Ann Gerdes 👇

🏃‍♂️‍➡️🏃‍♀️‍➡️ A team of 19 researchers, along with our managing director and Team Captain, Tobias Niemann, participated in the largest running event to raise funds for spinal cord injury research—the Wings for Life World Run.

More: synergy-munich.de/news-events/...

Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session

A study led by Anna-Sophia Wahl (@isd-research.bsky.social) reveals that the survival of place cells with stable coding for spatial information can be a strong predictor of positive cognitive outcomes following a #stroke.

🔗Read a summary on our website: synergy-munich.de/news-events/...