Marcela Uliano-Silva

When someone says „Scientists do not want you to know“ you can dismiss everything from there on. Scientists want you to know. They are desperate that you know. They can’t shut up about what they found out and want you to know.

It was fun! Talked about all the experience we have at the Tree of Life as we produce and release thousands of genomes! #sangerInstitute #TreeOfLife www.sanger.ac.uk/programme/tr...

I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!

Unveiling - Home

We need your help! If you have a few minutes, please fill out a very short survey about your preferences on butterflies and art - all responses are welcome! www.unveiling.eu

This is part of a project that aims to understand how the beauty of butterflies influences conservation: Unveiling (1/2)

final week to apply for @sangerinstitute.bsky.social PhD programme (due Nov 27th) -- free to apply, open to anyone anywhere, and a superb training opportunity for students interested in genomic approaches applied to biodiversity, pathogens, vectors, and of course us pesky humans.

We’ve just started our 5-day course with @marcelauliano.bsky.social & Joao on assembling eukaryotic genomes with @pacbio.bsky.social long reads and Hi-C! Attendees are learning how to handle raw data, run assemblies, scaffold chromosomes & assess quality.

Join our 5-day online course: “Eukaryotic Genome Assembly Using @pacbio.bsky.social and Hi-C” with @marcelauliano.bsky.social l & Joao and get hands-on experience with long-read sequencing and Hi-C scaffolding.

Last seats left: www.physalia-courses.org/courses-work...

Amanda Gardiner follows at the #biodiversity25 with a presentation about #genetic_diversity in sharks, rays and other vertebrates. She analyzed ROH, homozygous regions in vertebrates genomes produced by the VGP. Critically endangered species have more frequently long ROH than other species.

Elisa Ramos brings us a presentation about #gulls at the #biodiversity25. The large white-headed gulls lineage has one of the faster #radiation processes of the birds of the northern hemisphere. LarOmics project aims to elucidate the genetic base of the gull #evolution.

I am genuinely impressed by large language models - they can absorb disparate components of text into some consolidated view, they can produce extremely good language and - with the right model - translate pretty well between languages and they are an excellent text based UI for humans to use. But..

Celebrating the first 1000 genomes of Lepidoptera in Europe, sequenced at @sangerinstitute.bsky.social in collaboration with sampling hubs across the UK via the DToL project www.darwintreeoflife.org & across Europe via
@projectpsyche.bsky.social www.projectpsyche.org &
@10klepgenomes.bsky.social

ERGA meets VGP in New York City Last week, ERGA was present at the Vertebrate Genomes Project 2025 Conference, held at The Rockefeller University in New York City from September 30 and October 1. ERGA and VGP share a long-standing c...

🏙️ Last week, #ERGA joined the @vertebrategenomes.bsky.social #VGP Conference in NYC, a great chance to connect with @ebpgenome.bsky.social projects and share progress on #FAIR genome assemblies & reporting under @biogeneurope.bsky.social
www.erga-biodiversity.eu/post/erga-me... #genomes #conference

Early bird applications are now open! Go go go genomics!

Retrocopy formation and domestication shape genome evolution in sloths and other xenarthrans Xenarthrans, comprising sloths, anteaters, and armadillos, represent one of the most morphologically and physiologically specialised mammalian clades, yet the genomic basis of their adaptations remain...

Preprint Alert! 🦥
We produced complete genomes for 2 Xenarthra and placed them in a mammalian comparative framework. We found that Xenarthra harbour the largest number of retrocopies in mammals! www.biorxiv.org/content/10.1...

Retrocopy formation and domestication shape genome evolution in sloths and other xenarthrans Xenarthrans, comprising sloths, anteaters, and armadillos, represent one of the most morphologically and physiologically specialised mammalian clades, yet the genomic basis of their adaptations remain...

These findings reveal a link between LINE1s and retrocopies — and their impact on sloth biology — offering new insight into genome evolution in mammals with very low metabolic demands. www.biorxiv.org/content/10.1...

We also highlight the LINE1s–retrocopies relationship, showing thousands of active LINE1s in sloths shaping these mammalian genomes. Are LINE1s and retrocopies, after all, the makers of slothfulness? +

Out of ~15,000 retrocopies in the 2-toed sloth (C. didactylus), 38 are sloth-only, expressed, retain ≥70% of parental ORF length, and show dN/dS < 0.5. Their functions? Many are linked to mitochondria and metabolism!+

Were these inserted in the branch leading to the Xenarthran LCA? NO! Only ~14% are Xenarthra-wide. But in sloths — Choloepus and Bradypus — ~50% of retrocopies are sloth-specific, inserted ~30 Mya. This let us search for signs of domestication. +

Retrocopy formation and domestication shape genome evolution in sloths and other xenarthrans Xenarthrans, comprising sloths, anteaters, and armadillos, represent one of the most morphologically and physiologically specialised mammalian clades, yet the genomic basis of their adaptations remain...

Preprint Alert! 🦥
We produced complete genomes for 2 Xenarthra and placed them in a mammalian comparative framework. We found that Xenarthra harbour the largest number of retrocopies in mammals! www.biorxiv.org/content/10.1...

PhD opportunity in Bodø! You’ll sequence genomes from invasive and non-invasive slug (A. vulgaris) populations to uncover the molecular basis of invasion dynamics. Supervised by Prof. Les Noble & co-supervisor by me. Fully funded, cutting-edge science, great team. Apply by Sept 21: shorturl.at/zJT06

Fantastic and elegant! By the amazing @charlottewright.bsky.social et al!

PhD opportunity in Bodø! You’ll sequence genomes from invasive and non-invasive slug (A. vulgaris) populations to uncover the molecular basis of invasion dynamics. Supervised by Prof. Les Noble & co-supervisor by me. Fully funded, cutting-edge science, great team. Apply by Sept 21: shorturl.at/zJT06

This was both fun and terrifying to tape! Awesome to talk with @glennislogsdon.bsky.social and @aphillippy.bsky.social about our sequencing data / paper, the improvements to large-scale sequencing projects, and what this means for our understanding of our DNA!

This Labour government has failed. People want real transformative politics – we will give it to them | Jeremy Corbyn More than 500,000 people have signed up to our new party to help build a genuine alternative to poverty, inequality and war, says former Labour leader Jeremy Corbyn

This Labour government has failed. People want real transformative politics – we will give it to them | Jeremy Corbyn

Struggling to find the tiny microchromosomes in draft bird genome assemblies?

Our new #preprint introducing MicroFinder can help: www.biorxiv.org/content/10.1...

🧵 below

(1/n)

@sangerinstitute.bsky.social

Proud to have authored this review with brilliant people. Hope we inspire more attempts to sequence the #protist genomes that are within reach! Huge thanks to Alexandra Schoenle for leading. #ProtistsOnSky
authors.elsevier.com/sd/article/S...

Frontiers | Genomic infrastructure for cetacean research and conservation: reference genomes for eight families spanning the cetacean tree of life Reference genomes from representative species across families provide the critical infrastructure for research and conservation. The Cetacean Genomes Project...

Among many things, we predicted 22 Ancestral Linkage Groups for cetaceans. Most species conserved them, while Balaenidae&Kogiidae independently fused the same two ALGs into their largest chrms. Ziphiidae shows specific fusions. Very glad to be part of this effort: www.frontiersin.org/journals/mar...

Now out! Paper led by @philmor1964.bsky.social and the The Cetacean Genomes Project. An effort by many, we present 13 new, high-quality reference genomes for cetaceans 🐬🐋 following @vertebrategenomes.bsky.social and @ebpgenome.bsky.social standards for a group that is very hard to sample from.

This course with @marcelauliano.bsky.social and @ferreiranunesjoao.bsky.social ‬will introduce the audience to a spectrum of methods which are present in a usual assembly workflow, starting from raw data and finishing with a fully assembled genome @pacbio.bsky.social

Check it out shorturl.at/UEmOH

Our newest unofficial video series—deep-sea animals that dance better than you 💃

Most sea cucumbers live a sedentary life on the bottom of the ocean, but some take a break from eating and pooping on the seafloor to go for a quick swim. They may do it as a defensive behavior or to find a mate.