Department of Molecular Biology and Genetics

🟠 25. listopad patří Mezinárodnímu dni za odstranění násilí páchaného na ženách a dívkách. Univerzita Karlova se k této iniciativě připojila společně s dalšími institucemi a symbolicky se zahalila do oranžové.

#OrangeTheWorld

TEAD4 regulates apical domain homeostasis and cell-positioning to maintain the trophectoderm lineage during preimplantation mouse embryo development In mammalian preimplantation embryos, different cell lineages occupy specific niches. For example, the outer trophectoderm (TE) comprises a monolayer of epithelialized cells surrounding the inner-cell...

www.biorxiv.org/content/10.1...

Check out the new preprint from the Laboratory of Early Mammalian Developmental Biology ( #LEMDB) from our department! 🐭

Our department spent the weekend in Šumava for the annual PhD retreat — sharing research, ideas, and great company. Between sessions we hiked, enjoyed good food, and soaked in the autumn scenery. Thanks to everyone who made it such a great mix of work and fun! @fscusb.bsky.social

GBE | Polyommatine Blue Butterflies Reveal Unexpected Integrity of the W Sex Chromosome Amid Extensive Chromosomal Fragmentation Linked to Telomere Restoration

Hospodářská, @petrnguyen.bsky.social et al. investigated genome size and karyotype in Polyommatus and Lysandra butterflies, rejecting polyploidy to confirm karyotypic diversification via chromosome fragmentation in Polyommatinae butterflies.

🔗 doi.org/10.1093/gbe/evaf157

#genome #evolution

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

📢 Applications are OPEN for the Master’s in Functional Genetics & Bioinformatics! Learn genomics, data science & molecular biology to prepare for research & biotech careers. Apply now 👉 www.prf.jcu.cz/en/faculty/d...
#Genetics #Bioinformatics #Masters #LifeSciences #Biotech

📢 Applications are OPEN for the Master’s in Functional Genetics & Bioinformatics! Learn genomics, data science & molecular biology to prepare for research & biotech careers. Apply now 👉 www.prf.jcu.cz/en/faculty/d...
#Genetics #Bioinformatics #Masters #LifeSciences #Biotech

The last talk before the coffee break will be given by Lenka Gahurová from the University of South Bohemia, with a fascinating talk about Long-Term Female Fertility of African Mole-Rats
#developmentalbiology #fertility #epigenetics #evodevo

National Postdoc Appreciation Week is an annual celebration designed to recognize the significant contributions postdoctoral scholars make to US research and discovery. Join the celebration September 15-19. Visit buff.ly/NVsPBCu for a list of events both virtual and in-person. #NPAW

PhD at Med Faculty, University of Belgrade! Study mitochondria-immune crosstalk in Parkinson’s as part of the MSCA-funded BICEPS network. Join cutting-edge neuroimmunology research! 🌍
🔗 Info: www.membranetrafficking.com/biceps/index... #PhD #Parkinsons #MSCA #neuroimmunology

Current insights into insect immune memory Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.

🪰 How do insects fight infections and remember them?

A new Review Article presents an overview of insect immune memory, from antiviral defences to transgenerational immunity, and the unanswered questions.

Current insights into insect immune memory Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.

In their eLife (@elife.bsky.social) review, Adam Bajgar and Gabriela Krejcova examine how immune memory works against viruses and bacteria. They spotlight open questions and propose Drosophila as a model to study innate immune memory and insect vaccination.
elifesciences.org/articles/105...

Immune cells don’t just fight infection—they manage the body’s energy too. A Trends in Biochemical Sciences spotlight on Nedbalova et al. shows they release adenosine, signaling other tissues to dial down energy use.
sciencedirect.com/science/arti...
elifesciences.org/articles/105...

Odsouzena nacisty, zavražděna komunisty.

Před 75 lety byla popravena Milada Horáková, absolventka Právnické fakulty Univerzity Karlovy a česká politička.

Nikdy nezapomeneme.

🚀 Curious about a PhD in life sciences?

Meet EMBL at the Doctoral Insights Symposium — 100% online & free. @embl.org

🔬 Hear from PIs, students & professionals from 20 top PhD programs across Europe!

🔗 www.doctoralinsights.at
#docinsights #phdprogram #lifesciences #gradschool #europe #symposium

And to Gabriela Krejčová, for her doctoral work entitled "The role of macrophages in the regulation of systemic metabolism in Drosophila", conducted in the lab of Adam Bajgar at the University of South Bohemia.

Online now - the Spotlight " #SAMcycle and #adenosine at the heart of immune conversations" from Tina Mukherjee and colleagues.

#macrophages #infection #immunometabolism #SAMtransmethylation

authors.elsevier.com/a/1lHcd3S6Gf...

Julius Lukeš and Jiří Macas Ranked as Top Molecular Biologists in the Czech Republic
@czechacademy.bsky.social

www.entu.cas.cz/en/news-even...

Adenozin - známá molekula, na kterou se molekulární biologové z Jihočeské univerzity podívali jinou optikou. Výsledek jejich výzkumu zaujal prestižní časopis Science. Na první pohled složitý mechanismus, na druhý už nesmírně zajímavý a univerzální proces, který se děje v každém organismu.

As of today we have three new MSc. owners 🤩 Congratulations!

PhD position in Neuroscience (4-years) on Magnetoreception!
Exciting project exploring magnetoreception in insects at the CIMeC
@cimecunitrento.bsky.social , University of Trento, Italy
Read more: phd.unitn.it/drcimec/116/... and r.unitn.it/en/cimec/nphys
contact: albrecht.haase@unitn.it

Congratulations to all the students who successfuly defended their bachelor thesis. Good luck for the upcoming state exams!

PhD Student Position - Nencki Institute of Experimental Biology

Nuclear physicist Alice Valkárová.

Parasitologist Julius Lukeš.

Biochemist Ivo Šafařík.

The awarded researchers with the President of the Czech Academy of Sciences. (Left to right: Ivo Šafařík, President of the CAS Radomír Pánek, Alice Valkárová, and Julius Lukeš).

🏅 Nuclear physicist Alice Valkárová and parasitologist Julius Lukeš received honorary medals De scientia et humanitate optime meritis from the Czech Academy of Sciences yesterday, and biochemist Ivo Šafařík was awarded the Jaroslav Heyrovský Medal for Merit in the Chemical Sciences. 1url.cz/MJJY4

🏅Významná jaderná fyzička Alice Valkárová a oceňovaný parazitolog Julius Lukeš získali nejvyšší ocenění Akademie věd ČR De scientia et humanitate optime meritis, uznávaný biochemik Ivo Šafařík medaili Jaroslava Heyrovského za zásluhy v chemických vědách.

1url.cz/MJJY4

Yesterday kicked off the joint Methods of Functional Genomics course by @fscusb.bsky.social and Biology centre ACRS (@czechacademy.bsky.social), featuring expert lecturers from EMBL (@embl.org). Excited for a week of cutting-edge insights and learning!

Excited to see the work of Nedbalova et al. (@elife.bsky.social) featured in a Science dispatch! SAM metabolism and adenosine recycling shown to be central to systemic regulation & immunity. The research highlight from @tomasdolezal.bsky.social lab in @science.org
www.science.org/doi/epdf/10....

🤝 IOCB Prague is hiring – we are looking for an outstanding Junior Group Leader in Biosciences to join our vibrant scientific community.

See more ► www.uochb.cz/en/open-posi... ⤵️

#openposition #iocbprague #iocb #researchjobs #biosciences