Meg Davis

A prefrontal cortex map based on single-neuron activity - Nature Neuroscience The authors mapped spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity...

www.nature.com/articles/s41...

Awesome microscopy, as always! www.nature.com/articles/s41...

Dopamine responses in medial frontal cortex are more consistent with a generalized arousal signal than signed reward prediction errors. The past two decades have seen increased interest in the function of dopamine (DA) by virtue of its role in generating Reward-Prediction Errors (RPEs) in the service of Reinforcement Learning. From th...

www.jneurosci.org/content/earl...

Breaking boundaries: Dopamine’s role in prediction error, salient novelty, and memory reconsolidation For memories to remain relevant and adaptive over the lifespan, modifications under specific conditions are required. Memory reconsolidation theory su…

www.sciencedirect.com/science/arti...

www.pnas.org/doi/10.1073/...

Dual cholinergic mechanisms for sculpting striatal dopamine in vivo Striatal dopamine (DA) and acetylcholine constitute a computationally powerful neuromodulatory dyad that orchestrates action selection, motivational vigor, and reward learning. Striatal cholinergic in...

www.biorxiv.org/content/10.6...

Oscillatory control of cortical space as a computational dimension Chen et al. show that alpha/beta oscillations form spatially structured patterns across the cortical surface that encode task context and dynamically gate the expression of sensory information in spik...

www.cell.com/current-biol...

GAD65 GFP and parvalbumin.

Neurotoxic effects of chronic ethanol on cholinergic interneurons in the dorsomedial striatum Alcohol use disorder (AUD) has severe adverse health and economic impacts totaling over $240 billion in the U.S. annually. Despite this, FDA approved …

www.sciencedirect.com/science/arti...

If you're interested in Parkinson's disease or dietary interventions for PD, check out this podcast where we discuss our recent EJN article.

FENS-EJN Journal club Episode 1: Mitochondria, Ketones & Dopamine with Vikrant Mahajan and Armando Salinas
www.podbean.com/ew/pb-ikekv-...

Our article exploring the neurobiological correlates of prenatal cannabis exposure is now out! "Prenatal cannabis exposure, the brain, and
psychopathology during early adolescence" https://rdcu.be/dMJqH

New insights into axonal regulators of dopamine transmission in health and disease Dopamine release in the striatum is credited with being critical to the selection and learning of motivated actions and outcomes. Dysregulation of str…

www.sciencedirect.com/science/arti...

x.com/zenbrainest/...

Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neurons In this chapter we first focus our discussions on the late development and maintenance of nigrostriatal dopaminergic neurons (DANs), particularly the …

www.sciencedirect.com/science/arti...

My quote of the day

For a successful technology, reality must take precedence over public relations, for Nature cannot be fooled.

Richard Feynman

Parvalbumin in blue, NK1R in green. Note the matrix enrichment of the interneurons expressing these markets in DMS.

If you inject a CaMk promoter controlled or D1-cre dependent virus into PFC, you get anterograde viral transport AND frequently infect D1 expressing cells in striosomes in medial striatum (red). This is a D1-Cre mouse with a cre dependent AAV9 virus. CaMK is less selective.

Perfect. ❤️

Presynaptic and postsynaptic determinants of claustro-cortical connectivity de la Torre-Martínez et al. dissect the synaptic organization of claustro-cortical pathways using in vivo and slice recordings combined with optogenetics. By targeting two neuronal populations in the ...

But what about SST/CaMK+ GABA projections? I’ve seen them between CLA and PL www.cell.com/current-biol...

Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice

sciencemission.com/Alcohol-cons...

Cannabinoid CB1 receptor-sensitive neurodevelopmental processes and trajectories - Molecular Psychiatry Molecular Psychiatry - Cannabinoid CB1 receptor-sensitive neurodevelopmental processes and trajectories

www.nature.com/articles/s41...

Nice work, but what about PrL cortex to DM striosomes vs M1 projections to matrix? Maybe that’s coming… www.science.org/doi/pdf/10.1...

Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eatin...

www.science.org/doi/10.1126/...

Cannabinoid receptors in basket cell axons surrounding a hippocampal pyramidal cell. The CB1 receptor is presynaptic and expressed at high levels on GABAergic axons. Not necessarily ‘excitatory’ for the PC. It’s the oscillations!

Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion - Nature Communications Striatonigral neurons comprise diverse subtypes, yet their specific roles in locomotion regulation are not fully understood. Here, authors demonstrate that the Calb1+ subtype promotes locomotion, whil...

www.nature.com/articles/s41...

Addition to the oddities of transgenics: When breeding NR2A knockouts back in the day, they would have seizures upon introduction. They recovered quickly and resumed the task, but weren’t great breeders or mothers. (Thinking of those of you forced to cull your mice. They have no idea…)

Useful information for those new to mice. See Jax Labs for more excellent information on all things mouse.

This is actually a mini paper shredder for sale at Target. I had to do a double-take. IYKYK

I’ve attributed the vglut1/2 in the ventral shell to thalamus vs cortex but this could explain why things are weird in medial shell.