Nuclear import increases ASO activity by by RNase H and splice switching mechanisms
We have dramatically increased splice switching *and* RNase-H ASO activity by conjugating a nuclear importer!
Published in JACS (@jacs.acspublications.org )
Led by Disha Kashyap, with Tom Milne+@natahub.org
@uclchemistry.bsky.social 🧬🧪 #chemsky
pubs.acs.org/doi/10.1021/...
05.08.2025 08:26 — 👍 23 🔁 6 💬 1 📌 0
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.
See thread for more information and reach out!
22.07.2025 19:34 — 👍 103 🔁 116 💬 2 📌 1
Excited to share the latest paper from the Riglar lab @imperialinfect.bsky.social & @crick.ac.uk.
We use #synbio for biosensor discovery in our quest to build 'smart probiotics' to sense and treat disease.
Well done @clare-r.bsky.social et al!
Thanks to @wellcometrust.bsky.social for funding!
20.07.2025 19:25 — 👍 10 🔁 4 💬 0 📌 0
Please RT! Call for Fellows! If you’re a structural biologist and wanting to start your lab by applying for an external Fellowship then we at Imperial may be excited to host you. Synthetic biologists too.. Please submit expression of interest with details below 🙏
www.imperial.ac.uk/media/imperi...
28.07.2025 16:13 — 👍 20 🔁 30 💬 0 📌 1
Dad of two, Professor, Lister Research Fellow and Wellcome Investigator at the John Innes Centre. Interested in bacterial chromosome organization & segregation, plasmids, and phages.
www.tunglelab.org
Microbial evolution / University of Manchester
Assistant Professor at University of Calgary, Canada | Understanding and editing microbiomes using ecology | Mountain and trail runner🏃♂️⛰ | Postdoc in 🇬🇧, PhD in 🇨🇭 (he/him)
https://erikbakkeren.com/
Tenured Scientist in Synthetic Biology
(INRAE, Paris Area, France)
#CellFree ⦁ #SynBio ⦁ #Bioengineering ⦁ #Microbiology
https://sites.google.com/view/olivierborkowski
We're the Medical Research Council Laboratory of Medical Sciences. TeamScience: #Aging #SexDifferences #Environment #Genes #Metabolism #CellFate; Translation: #Multimorbidity; Training: #Transdisciplinary & #ClinicianScientist. www.lms.mrc.ac.uk
Evangelist for the study of evolution in action by everyone.
Pitt Prof | EvolvingSTEM | biofilms | EvMed | genomics entrepreneur (@SeqCoast.bsky.social, @midauthorbio.bsky.social) | ASM President-Elect | exercise addict ~ swim bike run
Emmy Noether Research Group Leader Immuno-Materials @ Leibniz INM and @ MaxPlanck Bristol | Combining SynBio and immunology with synthetic cells, biophysics, organoids
Our lab uses coacervate based materials to investigate protocells, synthetic cells, and biomolecular condensates.
*Operated by the lab
spruijtlab.com
BBSRC Fellow and Assistant Professor in Soft Matter and Life-like Systems. / Dept. Life Sciences, Imperial College London /📍London 🇬🇧 https://continilab.com
Network of excellent European research institutions that have joined forces to collaborate on synthetic cell research and accelerate its translation into technology
How to specifically select a protein from one side of the membrane and to transport it on the other side ? That's what we love to understand. #T6SS #T9SS
Location: CNRS - Aix-Marseille Université, France
https://www.cascaleslab.fr
Prof & Canada Excellence Research Chair | UBC Zoology, M&I | Oxford Biology | Evolution, ecology, host-pathogen, biodiversity | #firstgen | she/her/hers
Scientist working on antibiotic resistance, evolution, and mobile genetic elements. Prof at U.Oxford and Fellow of All Souls College
Evolutionary microbiologist interested in AMR & microbiomes 🦠 UKRI Future Leaders Fellow & Group Leader @ Queen’s University Belfast. she/her. Ex-GB athlete 🇬🇧
Protein Biochemist and Structural Biologist |
Postdoctoral Training Fellow at Sebastian Guettler’s group, the Institute of Cancer Research
| former: Low Group, Imperial College, Fasshauer Group, UniL and DCI Lausanne | #cryo-EM #teamtomo
Combining 3D biofabrication with synthetic biology via artificial cells | Biomed Eng PhD Candidate
TU Eindhoven | van Hest Lab | The Research Center for Materials Driven Regeneration
Lorenzo Di Michele's research group at @cebcambridge.bsky.social University of Cambridge (and also a bit at Imperial College). Working on DNA/RNA nanotechnology and Synthetic Cells
Eugene Bell Assistant Prof at MIT • tissue engineering the neuromuscular system to restore mobility and power robots • RamanLab.mit.edu
Research Theme at Newcastle University
Investigating microbial interactions in human hosts
https://www.ncl.ac.uk/medical-sciences/research/research-themes/microbes-in-health-and-disease/
