Nuclear import increases ASO activity by by RNase H and splice switching mechanisms
We have dramatically increased splice switching *and* RNase-H ASO activity by conjugating a nuclear importer!
Published in JACS (@jacs.acspublications.org โฌ)
Led by Disha Kashyap, with Tom Milne+@natahub.org โฌ
@uclchemistry.bsky.social ๐งฌ๐งช #chemsky
pubs.acs.org/doi/10.1021/...
05.08.2025 08:26 โ ๐ 22 ๐ 6 ๐ฌ 1 ๐ 0
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.
See thread for more information and reach out!
22.07.2025 19:34 โ ๐ 103 ๐ 116 ๐ฌ 2 ๐ 1
Excited to share the latest paper from the Riglar lab @imperialinfect.bsky.social & @crick.ac.uk.
We use #synbio for biosensor discovery in our quest to build 'smart probiotics' to sense and treat disease.
Well done @clare-r.bsky.social et al!
Thanks to @wellcometrust.bsky.social for funding!
20.07.2025 19:25 โ ๐ 10 ๐ 4 ๐ฌ 0 ๐ 0
Please RT! Call for Fellows! If youโre a structural biologist and wanting to start your lab by applying for an external Fellowship then we at Imperial may be excited to host you. Synthetic biologists too.. Please submit expression of interest with details below ๐
www.imperial.ac.uk/media/imperi...
28.07.2025 16:13 โ ๐ 19 ๐ 30 ๐ฌ 0 ๐ 1
Associate Professor, MIT
Still thinking about the 10^9 mutations generated in your microbiome today.
Website: http://lieberman.science
Professor & NHMRC Fellow at Monash University, Melbourne. Using microbes to tackle global challenges in health and sustainability. #FirstGen ๐ถ๐ฆ๐บ๐๐น๐ฑ
Assistant Professor@ASU | Microbial behaviour and interactions at the Microscale
https://www.microbialeco.systems/
Associate Prof. at the Dunn School and Magdalen College, University of Oxford. The lab studies the molecular and cellular basis of bacterial pathogenesis.
Evolutionary biologist (Multicellularity & social evolution). Prof. at Georgia Tech & Director of the QBioS PhD program.
https://ratclifflab.biosci.gatech.edu/
We study general principles that organise microbial systems, at ETH Zรผrich and Eawag | Posts by group members
https://mse.ethz.ch
Junior Group Leader @ Biozentrum-UniBasel & DMF-UNIL
Physicist turned biologist | Ecology & evolution of complex systems | Emergent behavior in microbial systems
vanvlietlab.ch
Institute of Chemical Biology, Centre for Doctoral Training, ICB-CDT, Imperial College London, Chemistry
๏ปฟWe are Imperialโs world-changing Faculty of Medicine. Where scientific imagination leads to biomedical discovery and clinical progress for the benefit of humanity.
Study with us: https://www.imperial.ac.uk/medicine/study/
๐ Imperial College London
Coordinating synthetic and engineering biology research and innovation across Bristol. Official account of the University of Bristol.
https://www.bristol.ac.uk/biodesign-institute
Associate Prof of ChemBio+OrgChem at UCL Chemistry, Royal Society URF #NewPI, chemistry, DNA/RNA, synthetic biology. Coeliac. Dad. ๐ธ boothlab.uk
๐Direct DNA/RNA analysis for anyone, anywhere
๐งฌShort to ultra-long reads in real-time for rapid insights
๐ฌProducts for research use only
Professor for Mucosal Immunology, ETH Zรผrich, Switzerland, and Sir William Dunn School of Pathology, Oxford, UK. We work on novel oral vaccines, AMR, and microbiome function. Making science fairer, kinder and more equitable ๐ณ๏ธโ๐๐ณ๏ธโโง๏ธ. Views are my own.
typing...
(also active on X as @cees_dekker)
Associate Professor of Biomedical Engineering
Duke University
Microbiologist interested in gut microbiota-pathogen interaction. Professor at TU Munich, PhD ETH Zurich, studies at LMU Munich and University of Warwick, UK.
We work on the type VII secretion system and are interested in Gram positive competitive mechanisms.
Interdisciplinary Research Centre for Synthetic and Engineering Biology at the University of Cambridge. Bringing together researchers working across disciplines - at the intersections of biology, engineering, computer science, design and bioethics.
UK EPSRC BBSRC Centre for Doctoral Training in Engineering Biology, Universities of Bristol and Oxford
